FlyBase Allele Report: Dmel\AGO3[t2]

General Information

Symbol

Dmel\AGO3^t2

Species

D. melanogaster

Name

FlyBase ID

FBal0239063

Feature type

allele

Associated gene

Dmel\AGO3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Li et al., 2009)

Progenitor genotype

Cytology

Description

Deletion of amino acid residues 513 through to amino acid residue 523, which has also been replaced by a stop codon.

(Li et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:23,569,710..23,569,742 [+]

Comment:

Reported as a deletion of residues N513 to D523, leading to a premature stop. Exact deletion endpoints not reported.

(Li et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by caz^RNAi.UAS.cUa

(Wakisaka et al., 2019)

modeled by caz^HMS00790

(Wakisaka et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with AGO3^t3)

(Li et al., 2009)

male semi-sterile (with AGO3^t3)

(Li et al., 2009)

viable (with AGO3^t1)

(Li et al., 2009)

viable (with AGO3^t3)

(Li et al., 2009)

viable (with Df(3L)TTT)

(Li et al., 2009)

Phenotype Manifest In

dorsal appendage | maternal effect (with AGO3^t3)

(Li et al., 2009)

egg | maternal effect (with AGO3^t3)

(Li et al., 2009)

Detailed Description

Statement

Reference

AGO3^t2/AGO3^t3 females are sterile, initially laying far fewer eggs than their control siblings and stopping laying altogether by stage 10. None of the eggs laid by these females hatch and many of them have fused or missing dorsal appendages.

AGO3^t2/AGO3^t3 males are semifertile, siring fewer offspring than do control males with the same genetic background. Ste protein crystals form in primary spermatocytes in AGO3^t2/AGO3^t3 testes.

(Li et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

AGO3[+]/AGO3^t2 is a suppressor | partially of partially lethal - majority live phenotype of ct^A, lncRNA:flam^A

(Guida et al., 2016)

AGO3[+], AGO2⁴¹⁴, AGO3^t2, AGO2[+] is a suppressor of partially lethal - majority live phenotype of ct^A, lncRNA:flam^A

(Guida et al., 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The mortality exhibited by flam^A, ct^A double homozygotes is suppressed by either AGO3^t2 heterozygosity (partial suppression) or AGO2⁴¹⁴, AGO3^t2 double heterozygosity (full suppression).

(Guida et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

AGO3^LOF

(Ochoa et al., 2023)

AGO3^T2

(Lee et al., 2025, Teixeira et al., 2017)

AGO3^t2

(Ochoa et al., 2023, Wakisaka et al., 2019, Guida et al., 2016, Minakhina et al., 2014)

AGO3^t2t2

(Liu et al., 2011)

Ago3^T2

(Yang et al., 2015)

ago3^T2

(Venkei et al., 2023)

ago3^t2

(Iki et al., 2023, Lin et al., 2023, Lim et al., 2022, Andress et al., 2016, Wang et al., 2015, Patil et al., 2014, Perrat et al., 2013, Anand and Kai, 2012, Kibanov et al., 2011, Zhang et al., 2011, Nagao et al., 2010, Patil and Kai, 2010, Li et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (22)

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