FlyBase Allele Report: Dmel\ct[A]

General Information

Symbol

Dmel\ct^A

Species

D. melanogaster

Name

FlyBase ID

FBal0325442

Feature type

allele

Associated gene

Dmel\ct

Associated Insertion(s)

gypsy{}ct^A

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Guida et al., 2016)

Progenitor genotype

Associated Insertion(s)

gypsy{}ct^A

Cytology

Description

Insertion of a gypsy element in the ct regulatory region.

(Guida et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:7,541,697..7,541,697 [-]

(Cavaliere et al., 2020, Guida et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Guida et al., 2016)

visible (with ct⁶)

(Guida et al., 2016)

Phenotype Manifest In

wing

(Guida et al., 2016)

wing (with ct⁶)

(Guida et al., 2016)

Detailed Description

Statement

Reference

ct^A homozygotes and ct^A/ct⁶ transheterozygotes exhibit a cut-wing phenotype, as compared to controls.

(Guida et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, enhanceable by AstC-R2[+]/AstC-R2^f03116

(Guida et al., 2016)

Suppressed by

Statement

Reference

ct^A has visible phenotype, suppressible by su(Hw)⁸/su(Hw)⁸

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible by AGO3[+]/AGO2⁴¹⁴/AGO3^t2/AGO2[+]

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible by Su(var)3-7^DG10405/Su(var)3-7[+]

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible | partially by Su(var)205⁵/Su(var)205[+]

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible by Su(var)3-9¹/Su(var)3-9[+]

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible | partially by Su(var)3-9[+]/Su(var)3-9²

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible | partially by AGO2⁴¹⁴/AGO2[+]

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible | partially by Dcr-2[+]/Dcr-2^L811fsX

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible | partially by AGO3[+]/AGO3^t2

(Guida et al., 2016)

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype, suppressible | partially by aub[+]/aub^HN2

(Guida et al., 2016)

Other

Statement

Reference

ct^A, lncRNA:flam^A has partially lethal - majority live phenotype

(Guida et al., 2016)

AstC-R2^f03116, ct[+]/ct^A, lncRNA:flam^A has partially lethal - majority live phenotype

(Guida et al., 2016)

AstC-R2^f03116, ct^A, lncRNA:flam^A has lethal - all die before end of P-stage phenotype

(Guida et al., 2016)

ct[+]/ct^A, f^A/f[+], lncRNA:flam^A has increased mortality phenotype

(Guida et al., 2016)

ct^A, lncRNA:flam^BG02658 has partially lethal - majority live phenotype

(Guida et al., 2016)

ct⁶/ct^A, lncRNA:flam¹/lncRNA:flam^A has increased mortality phenotype

(Guida et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

ct^A has wing phenotype, suppressible by su(Hw)⁸/su(Hw)⁸

(Guida et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

su(Hw)⁸ homozygozity suppresses the cut-wing defects exhibited by ct^A homozygotes.

Both flam^BG02658,vct^A double homozygotes and flam^A/flam^A, AstC-R2^f03116/AstC-R2^f03116, ct^A/+ mutants present significant mortality during the pharate stage, as compared to controls.

flam^A, ct^A double homozygotes display significant mortality during the pharate stage as compared to controls, which is significantly increased or even reaches full lethality by AstC-R2^f03116 heterozygosity or homozygosity, respectively; these flam^A, ct^A, AstC-R2^f03116 triple homozygous lethal pharates become trapped in the pupal case, still exhibiting pupal membrane attached to several body parts; the mortality of flam^A, ct^A double homozygotes is suppressed by heterozygosity for either Su(var)3-7^DG10405, Su(var)205⁵, Su(var)3-9¹, Su(var)3-9², AGO2⁴¹⁴, Dcr-2^L811fsX, AGO3^t2 or aub^HN2, or by AGO2⁴¹⁴, AGO3^t2 double heterozygosity; flam^A/flam¹, ct^A/ct⁶ double transheterozygotes show a small but significant increase in mortality as compared to flam^A/flam¹ single heterozygotes.

flam^A homozygotes also double transheterozygous for ct^A and f^A exhibit a small but significant increase in pharate mortality, as compared to controls.

(Guida et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

ct^A was identified as a spontaneous mutation in the AstC-R2^f03116 line. The chromosome carrying ct^A also carries a permissive flam allele (flam^A).

(Guida et al., 2016)

Separable from: flam^A.

(Guida et al., 2016)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ct^A

(Cavaliere et al., 2020, Guida et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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