FB2026_02 , released June 18, 2026
Allele: Dmel\lncRNA:flam1
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General Information
Symbol
Dmel\lncRNA:flam1
Species
D. melanogaster
Name
FlyBase ID
FBal0045643
Feature type
allele
Associated gene
Dmel\lncRNA:flam
Associated Insertion(s)
Carried in Construct
Also Known As
flam1
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        flam1 homozygotes, but not flam1/flamA transheterozygotes, display increased mortality as compared to controls.

        (Guida et al., 2016)

        A flam1/flam1 permissive germline (which is surrounded by a flam1/flamovoD1 restrictive soma) is not sufficient by itself to induce the high frequency of ovoD1 inactivation (indicative of gypsy transposition) which is seen in the progeny of non-mosaic flam1/flam1 control females. The frequency of ovoD1 inactivation in the progeny of mosaic females (containing a flam1/flam1 permissive germline surrounded by a flam1/flamovoD1 restrictive soma) and of non-mosaic flam1/flamovoD1 females is one order of magnitude less than that of non-mosaic flam1/flam1 control females.

        (Chalvet et al., 1999)

        Homozygosity at flam1 in females permits mobilization of the gypsy element in the progeny.

        (Prud'homme et al., 1995)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        lncRNA:flam1 has increased mortality | pharate adult stage phenotype, enhanceable by ct6/ct6

        (Guida et al., 2016)
        NOT Enhanced by
        Statement
        Reference

        lncRNA:flam1 has increased mortality | pharate adult stage phenotype, non-enhanceable by ctn/ctn

        (Guida et al., 2016)
        Other
        Phenotype Manifest In
        Other
        Statement
        Reference

        Bx2, lncRNA:flam1 has wing phenotype

        (Guida et al., 2016)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        ct6, flam1 double homozygotes present significant lethality during the pharate stage, as compared to both ct6 and flam1 single homozygotes.

        The pharate mortality of flam1 homozygotes is not significantly increased by ctn homozygozity.

        flamA/flam1, ctA/ct6 double transheterozygotes show a small but significant increase in mortality as compared to flamA/flam1 single heterozygotes.

        Bx2, flam1 double homozygotes display scalloped wing margin defects and wing blistering in a significant proportion of the population.

        (Guida et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        flam1 is not completely recessive and flam1 homozygotes show a stronger phenotype (i.e. induce more instability) than flam1/deficiency.

        (Prud'homme et al., 1995)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        flam1
        (Genenncher et al., 2018, Guida et al., 2016)
        lncRNA:flam1
        Name Synonyms
        Secondary FlyBase IDs
          References (8)