FlyBase Allele Report: Dmel\Bx[2]

General Information

Symbol

Dmel\Bx²

Species

D. melanogaster

Name

FlyBase ID

FBal0001432

Feature type

allele

Associated gene

Dmel\Bx

Associated Insertion(s)

gypsy{}Bx-2a

gypsy{}Bx-2b

Carried in Construct

Also Known As

Dlmo^Bx2

Key Links

Allele class

hypermorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypermorphic allele - genetic evidence

(Rabinow et al., 1993)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

gypsy{}Bx-2a

gypsy{}Bx-2b

Cytology

Description

Insertion of approximately 8kb into the 3' UTR.

(Shoresh et al., 1998)

Insertion of dual gypsy elements.

(Rabinow et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size

(Ren et al., 2014)

chemical resistant

(Tsai et al., 2004)

viable

visible

(Georgiev and Gerasimova, 1989)

visible | adult stage (with Bx^hdp48-1)

(Zenvirt et al., 2008)

visible | adult stage (with Bx^hdp58-1)

(Zenvirt et al., 2008)

visible | adult stage (with Bx^hdp67-2)

(Zenvirt et al., 2008)

visible | adult stage (with Bx^hdp185-1)

(Zenvirt et al., 2008)

visible | adult stage | dominant

(Zenvirt et al., 2008)

visible | dominant

Phenotype Manifest In

wing

(Guida et al., 2016, Ren et al., 2014, Zenvirt et al., 2008, Georgiev and Gerasimova, 1989)

wing (with Bx^hdp48-1)

(Zenvirt et al., 2008)

wing (with Bx^hdp58-1)

(Zenvirt et al., 2008)

wing (with Bx^hdp67-2)

(Zenvirt et al., 2008)

wing (with Bx^hdp185-1)

(Zenvirt et al., 2008)

wing margin

(Ren et al., 2014, Bronstein et al., 2010)

wing vein

Detailed Description

Statement

Reference

Bx² homozygotes display scalloped wing margin defects, but not wing blistering.

(Guida et al., 2016)

Homozygotes have small wings with and lack much of the wing margin. Heterozygotes show a similar albeit weaker phenotype.

Bx^A523/Bx² wings appear wild type. This phenotype is less severe than Bx² wings and is similar to Bx² /+ wings.

(Ren et al., 2014)

Heterozygous females and hemizygous males show a wing notching phenotype - the male hemizygous phenotype is considerably more severe.

(Bronstein et al., 2010)

Bx²/+ mutant wings exhibit scalloping. No other obvious abnormalities are observed.

One copy of Bx^hdp48-1 partially rescues the wing scalloping phenotype seen in Bx²/+ flies.

One copy of Bx^hdp185-1 partially rescues the wing scalloping phenotype seen in Bx²/+ flies.

One copy of Bx^hdp58-1 partially rescues the wing scalloping phenotype seen in Bx²/+ flies.

One copy of Bx^hdp67-2 partially rescues the wing scalloping phenotype seen in Bx²/+ flies.

One copy of Df(1)N19 partially rescues the wing scalloping phenotype seen in Bx²/+ flies.

(Zenvirt et al., 2008)

Mutant animals exhibit an decreased sensitivity to cocaine.

(Tsai et al., 2004)

Wing is narrowed by excisions on both margins.

(Georgiev and Gerasimova, 1989)

RK1 (RK3 as heterozygous female).

(Schultz, 1934)

Wings of males and homozygous females narrowed by marginal excision. Wings often bubbly and ragged. Only rarely affects wing vein L5.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Bx² is a suppressor | partially of visible | recessive | adult stage phenotype of ac¹

(Zenvirt et al., 2008)

NOT Suppressor of

Statement

Reference

Bx² is a non-suppressor of visible | adult stage phenotype of Chi^E

(Zenvirt et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Bx² has wing margin phenotype, enhanceable by ap[+]/ap^UGO35

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by l(3)mbn^KG02958/l(3)mbn[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Cyp6d4[+]/Cyp6d4^EY04319

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG14204[+]/CG14204^EY05761

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG1518[+]/Stt3A^KG03333

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by nub^KG07049/nub[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by nub^E37/nub[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG2604[+]/CG2604^EY05974

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Tina-1^KG05573/Tina-1[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by fng[+]/fng⁸⁰

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Gαs^B19/G-salpha60A[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Gαs^R60/G-salpha60A[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by RpS21[+]/RpS21⁰³⁵⁷⁵

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by eEF5⁰¹²⁹⁶/eIF-5A[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Df(2R)Kr10/+

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Kr²/Kr[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Kr[+]/Kr¹

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Hydr2[+]/Hydr2^EY06843

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Kat60^EY05593/katanin-60[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Ca-P60A[+]/SERCA^KG00570

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG4080[+]/CG4080^KG08382

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG4080[+]/CG4080^EY01375

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by tankyrase[+]/Tnks^EP3476

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Tango14[+]/Tango14^k00619

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by St3^KG01820/CG5431[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by fbl[+]/fbl¹

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Spn88Eb^e04451/Spn88Eb[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Mf^EY03476/Mf[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG11893^c03576/CG11893[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG7115[+]/CG7115^KG02655

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG7755^f06581/CG7755[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by ppl¹/ppl[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by ppl[+]/ppl⁰⁰²¹⁷

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Xbp1[+]/Xbp1^k13803

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Ar5^e02843/CG2767[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CtsF^EY02656/CG12163[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by CG12163[+]/CtsF^EY04405

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Fpps[+]/Fpps^k06103

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by Fpps[+]/Fpps^k03514

(Bronstein et al., 2010)

Bx² has wing margin phenotype, enhanceable by l(3)mbn^E1/l(3)mbn[+]

(Bronstein et al., 2010)

NOT Enhanced by

Statement

Reference

Bx² has wing margin phenotype, non-enhanceable by pnr[+]/pnr^V1

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-enhanceable by Fer2LCH[+]/Fer2LCH⁰⁰⁰³⁵

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-enhanceable by Fer2LCH[+]/Fer2LCH^neo60

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-enhanceable by CG31689^KG00713/CG31689[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-enhanceable by l(2)SH0211[+]/SERCA^SH0211

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-enhanceable by pex13[+]/Pex13^KG04339

(Bronstein et al., 2010)

Suppressed by

Statement

Reference

Bx² has wing margin phenotype, suppressible by CG11334[+]/Mri1^f05707

(Bronstein et al., 2010)

Bx² has wing margin phenotype, suppressible by CG11334[+]/Mri1^KG06246

(Bronstein et al., 2010)

Bx² has wing margin phenotype, suppressible by Sam-S[+]/Sams^KG04716

(Bronstein et al., 2010)

Bx² has wing margin phenotype, suppressible by Pex13^e02054/pex13[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, suppressible by CG7115^c05817/CG7115[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, suppressible by CG7115[+]/CG7115^KG02655

(Bronstein et al., 2010)

Bx² has wing margin phenotype, suppressible by CG9932^c00144/CG9932[+]

(Bronstein et al., 2010)

Bx² has phenotype, suppressible by mod(mdg4)^ul

(Georgiev and Gerasimova, 1989)

Bx² has phenotype, suppressible by su(Hw)²

(Georgiev and Gerasimova, 1989)

Bx² has phenotype, suppressible by su(Hw)^u1

(Georgiev and Gerasimova, 1989)

Bx² has phenotype, suppressible by su(Hw)^u2

(Georgiev and Gerasimova, 1989)

NOT suppressed by

Statement

Reference

Bx² has wing margin phenotype, non-suppressible by pnr[+]/pnr^V1

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-suppressible by Fer2LCH[+]/Fer2LCH⁰⁰⁰³⁵

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-suppressible by Fer2LCH[+]/Fer2LCH^neo60

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-suppressible by CG31689^KG00713/CG31689[+]

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-suppressible by l(2)SH0211[+]/SERCA^SH0211

(Bronstein et al., 2010)

Bx² has wing margin phenotype, non-suppressible by pex13[+]/Pex13^KG04339

(Bronstein et al., 2010)

Suppressor of

Statement

Reference

Bx² is a suppressor of posterior dorsocentral bristle phenotype of ac¹

(Zenvirt et al., 2008)

NOT Suppressor of

Statement

Reference

Bx² is a non-suppressor of anterior dorsocentral bristle phenotype of ac¹

(Zenvirt et al., 2008)

Bx² is a non-suppressor of anterior dorsocentral bristle phenotype of Chi^E

(Zenvirt et al., 2008)

Other

Statement

Reference

Bx², lncRNA:flam¹ has wing phenotype

(Guida et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Bx², flam¹ double homozygotes display scalloped wing margin defects and wing blistering in a significant proportion of the population.

(Guida et al., 2016)

Homozygous or hemizygous Bx² suppresses the anterior dorsocentral bristle loss seen in homozygous or hemizygous ac¹ mutants. The double mutant flies still show posterior dorsocentral bristle loss.

Flies carrying one copy of Chi^e5.5 and one copy of Bx² have a wild type number of dorsocentral bristles.

Bx² does not suppress the anterior dorsocentral bristle loss seen in Chi^E/+ mutant flies.

No dorsocentral bristle loss is seen in flies hemizygous for Bx² and heterozygous for pnr^VX6.

No dorsocentral bristle loss is seen in flies hemizygous for Bx² and heterozygous for pnr^MD237.

(Zenvirt et al., 2008)

Phenotype is partially suppressed by mod(mdg4)^ul; flies have middle size incisions on the internal wing margin only.

(Georgiev and Gerasimova, 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

135

un¹ Bx²/In(1)AM, ptg⁴

sc¹ pn³ g^2rv Bx²

Notes on Origin

Discoverer

Mohr, 29th Dec. 1924.

Comments

Bx²/+ less extreme; overlaps wild type.

Alleles fall into an allelic series based on cocaine resistance phenotype. Bx^J > Bx¹ = Bx² = Bx³.

(Tsai et al., 2004)

Classifiable in a single dose in triploids.

(Schultz, 1934)

No interaction with Doa alleles is observed.

(Rabinow et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Bx²

(Guida et al., 2016, Ren et al., 2014)

Dlmo^Bx2

(Bronstein et al., 2010)

dlmo^Bx2

(Zenvirt et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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