FlyBase Allele Report: Dmel\ac[1]

General Information

Symbol

Dmel\ac¹

Species

D. melanogaster

Name

FlyBase ID

FBal0000160

Feature type

allele

Associated gene

Dmel\ac

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Garcia-Bellido, 1979)

Mutagen

spontaneous

(Campuzano et al., 1985)

Progenitor genotype

Cytology

Description

A deficiency extending from a point between kb 64.9 and 63.5, which is approximately 5 kb upstream from the presumptive ac transcription unit, to the left to approximately kb 82. Deletion.

(Campuzano et al., 1985)

Deletion for kb 84 to 64; includes y.

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage | recessive

(Zenvirt et al., 2008)

visible | recessive

(Held, 1990)

Phenotype Manifest In

acrostichal bristle

anterior dorsocentral bristle

(Zenvirt et al., 2008)

anterior supraalar bristle

interocellar bristle

interommatidial bristle

mesothoracic leg sensillum | ectopic

(Held, 1990)

mesothoracic tarsal bristle

(Held, 1990)

posterior dorsocentral bristle

(Zenvirt et al., 2008)

posterior supraalar bristle

Detailed Description

Statement

Reference

Flies homozygous or hemizygous for ac¹ lack all four dorsocentral bristles. No phenotypes are seen in heterozygotes.

(Zenvirt et al., 2008)

The total number of bristles on the basitarsi of the second legs is reduced. The number of bractless bristles on the basitarsi remains normal. Significantly more bristles are missing from the anterior side of the basitarsus than from the posterior side. One or the other of the distal sensilla is sometimes missing, and an ectopic sensillum sometimes forms proximally between bristle rows 3 and 4.

(Held, 1990)

ac^Hw-1/ac¹ = ac^Hw-1/+.

(Sturtevant, 1970)

Posterior dorsocentral bristles missing; also posterior supra-alar and anterior vertical bristles frequently missing. Anterior dorsocentrals displaced anteriorly (FBrf0020635). Garcia-Bellido (FBrf0033191) finds anterior dorsocentral bristles more strongly decreased than posterior dorsocentrals. Hairs usually fewer near position of posterior dorsocentrals; interocellar hairs invariably fewer, typically absent. Eyes partly devoid of hairs. Trichomes unaffected. Limited nonautonomy near the borders of somatic spots with respect both to numbers and positions of bristles and hairs (FBrf0009297; FBrf0013897; FBrf0020635).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

ac¹ has visible | recessive | adult stage phenotype, suppressible | partially by Bx²

(Zenvirt et al., 2008)

Suppressor of

Statement

Reference

ac¹/sc¹ is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

Bx^hdp58-1/Bx[+], ac¹ has visible | adult stage phenotype

(Zenvirt et al., 2008)

Bx[+]/Bx^hdp185-1, ac¹ has visible | adult stage phenotype

(Zenvirt et al., 2008)

Bx^hdpR590/Bx[+], ac¹ has visible | adult stage phenotype

(Zenvirt et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

ac¹ has posterior dorsocentral bristle phenotype, suppressible by Bx²

(Zenvirt et al., 2008)

NOT suppressed by

Statement

Reference

ac¹ has anterior dorsocentral bristle phenotype, non-suppressible by Bx²

(Zenvirt et al., 2008)

ac¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Suppressor of

Statement

Reference

ac¹/sc¹ is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

ac¹/sc¹ is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

ac¹ is a suppressor of phenotype of hry¹

(Sturtevant, 1970)

Other

Statement

Reference

Bx^hdp58-1/Bx[+], ac¹ has anterior dorsocentral bristle phenotype

(Zenvirt et al., 2008)

Bx[+]/Bx^hdp185-1, ac¹ has anterior dorsocentral bristle phenotype

(Zenvirt et al., 2008)

Bx^hdpR590/Bx[+], ac¹ has anterior dorsocentral bristle phenotype

(Zenvirt et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Flies carrying one copy of ac¹ and one copy of Bx^hdp58-1 lack the anterior dorsocentral bristles. No phenotypes are observed in either heterozygote alone.

Flies carrying one copy of ac¹ and one copy of Bx^hdp185-1 lack the anterior dorsocentral bristles. No phenotypes are observed in either heterozygote alone.

Flies carrying one copy of ac¹ and one copy of Bx^hdpR590 lack the anterior dorsocentral bristles. No phenotypes are observed in either heterozygote alone.

Homozygous or hemizygous Bx² suppresses the anterior dorsocentral bristle loss seen in homozygous or hemizygous ac¹ mutants. The double mutant flies still show posterior dorsocentral bristle loss.

Homozygous or hemizygous Bx¹⁰⁰² suppresses the anterior dorsocentral bristle loss seen in homozygous or hemizygous ac¹ mutants. The double mutant flies still show posterior dorsocentral bristle loss.

(Zenvirt et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

ac^3B

(Garcia-Bellido, 1979)

Comments

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant