FlyBase Allele Report: Dmel\Bx[hdp48-1]

General Information

Symbol

Dmel\Bx^hdp48-1

Species

D. melanogaster

Name

FlyBase ID

FBal0282709

Feature type

allele

Associated gene

Dmel\Bx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Zenvirt et al., 2008)

Mutagen

Delta2-3 transposase

(Zenvirt et al., 2008)

Progenitor genotype

P{EPgy2}EY01065

(Zenvirt et al., 2008)

Cytology

Description

Excision of P{EPgy2}EY01065 has resulted in a deletion that removes exon 5 of Bx. The deletion extends into the upstream intron, removing an additional 634bp.

(Zenvirt et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | male limited

(Zenvirt et al., 2008)

some die during larval stage | male limited

(Zenvirt et al., 2008)

visible

(Zenvirt et al., 2008)

visible | adult stage (with Bx²)

(Zenvirt et al., 2008)

visible | adult stage (with Bx^5-1)

(Zenvirt et al., 2008)

Phenotype Manifest In

anterior dorsocentral bristle

(Zenvirt et al., 2008)

crossvein

(Zenvirt et al., 2008)

wing

(Zenvirt et al., 2008)

wing (with Bx²)

(Zenvirt et al., 2008)

wing (with Bx^5-1)

(Zenvirt et al., 2008)

Detailed Description

Statement

Reference

Flies homozygous or hemizygous for Bx^hdp48-1 have held-up wings, with occasional defects in the cross-veins. The wings are of a normal size. Between 10 and 20% of flies are missing one or two bristles from the anterior pair of the four thoracic dorsocentral bristles. This is increased to >85% in Bx^hdp48-1/Df(1)N19 females. Flies also show locomotor defects, having difficulty in standing and walking.

One copy of Bx^hdp48-1 partially rescues the wing scalloping phenotype seen in Bx^5-1/+ flies.

One copy of Bx^hdp48-1 partially rescues the wing scalloping phenotype seen in Bx²/+ flies.

(Zenvirt et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Bx^hdp67-2

(Zenvirt et al., 2008)

Bx^hdp58-1

(Zenvirt et al., 2008)

Bx^hdp185-1

(Zenvirt et al., 2008)

Bx^hdpR590

(Zenvirt et al., 2008)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Bx^hdp48-1

dlmo^hdp48-1

(Zenvirt et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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