FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Kr2
Open Close
General Information
Symbol
Dmel\Kr2
Species
D. melanogaster
Name
FlyBase ID
FBal0005791
Feature type
allele
Associated gene
Dmel\Kr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987, Preiss et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Preiss et al., 1985)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  acute myeloid leukemia
      modeled by Hsap\RUNX1::Hsap\RUNX1T1UAS.cSa
      (Sinenko et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Kr2 mutants exhibit a loss of malpighian tubules.

      (Uddin et al., 2011)

      One copy of Kr2 has no effect on hemocyte proliferation in third instar larvae.

      (Sinenko et al., 2010)

      Malpighian tubule buds are absent in homozygous embryos, although cells at the hindgut/midgut junction form a slightly distended tube. Midgut constrictions do not form normally.

      (Harbecke and Lengyel, 1995)

      Presence of Kr2 increases the frequency of abdominal segment 1 transformations due to ftzUal1 and increases the frequency of heat shock phenocopy in wild type embryos.

      (Welte et al., 1995)

      Nondefective in gonad assembly.

      (Warrior, 1994)

      Interacts with RpII140wimp maternal effect.

      (Parkhurst and Ish-Horowicz, 1991)

      No changes in phenotype of tor13D embryos.

      (Strecker et al., 1991)

      Thoracic and abdominal segments 1 to 5 are missing, abdominal segment 5 is duplicated.

      (Jack et al., 1988)

      Strong allele.

      (Preiss et al., 1985)

      strong allele Segments T1-3 and A1-5 deleted; A6 and sometimes A7 and 8 duplicated with reverse polarity.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Kr2 has Malpighian tubule phenotype, enhanceable by srp2

      (Uddin et al., 2011)
      Enhancer of
      Statement
      Reference

      Kr2 is an enhancer of midgut phenotype of srp2

      (Uddin et al., 2011)

      Kr2/Kr[+] is an enhancer of wing margin phenotype of Bx2

      (Bronstein et al., 2010)
      Suppressor of
      Other
      Statement
      Reference

      Kr2, srp2 has embryonic small intestine phenotype

      (Uddin et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Kr2 srp2 double mutants exhibit a loss of midgut, malpighian tubules and small intestine tissue.

      (Uddin et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference

      One copy of Kr2 strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1Scer\UAS.cSa is expressed under the control of Scer\GAL4Hml.Δ.

      (Sinenko et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong allele.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Kr2
      (Kao et al., 2012, Uddin et al., 2011, Bronstein et al., 2010, Sinenko et al., 2010, Sanders et al., 2008)
      Name Synonyms
      Kuppel2
      (Sanders et al., 2008)
      Secondary FlyBase IDs
        References (27)