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General Information
Symbol
Dmel\Su(var)3-92
Species
D. melanogaster
Name
FlyBase ID
FBal0016558
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Su(var)3-902
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G15260859A

Amino acid change:

C427Y | Su(var)3-9-PA

Reported amino acid change:

C427Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: C427Y.

Point mutation.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Strong suppressors of bw and w position effect variegation (PEV).

Dominant suppressor of position effect variegation at the w locus caused by In(1)wm4h.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Su(var)3-9[+]/Su(var)3-92 is a suppressor | partially of lethal | recessive phenotype of JIL-1z2

Phenotype Manifest In
Enhancer of
Statement
Reference

Su(var)3-9[+]/Su(var)3-92 is an enhancer of neuron phenotype of Hsap\MAPTR406W.UAS, Scer\GAL4elav.PU

Suppressor of
Statement
Reference

Su(var)3-9[+]/Su(var)3-92 is a suppressor | partially of polytene chromosome phenotype of JIL-1z2

Additional Comments
Genetic Interactions
Statement
Reference

Su(var)3-92 heterozygosity partially suppresses the mortality exhibited by flamA, ctA double homozygotes.

The lethality of JIL-1z2 homozygotes is significantly suppressed by one copy of Su(var)3-92 (50.7% viability).

The lethality of JIL-1z2 homozygotes is significantly suppressed by Su(var)3-91/Su(var)3-92 (55.8% viability).

The abnormal polytene chromosome morphology seen in JIL-1z2 homozygous third instar larvae is partially suppressed by Su(var)3-92/+ or Su(var)3-91/Su(var)3-92; the chromosome arms ar to a large extent unfolded with reduced ectopic contacts and there is a clearly discernible banding pattern that in some cases almost resembles the wild-type pattern. However, there is no discernible improvement in the morphology of the male X chromosome in the double mutants.

Xenogenetic Interactions
Statement
Reference

Heterozygous Su(var)3-92 enhances the Scer\GAL4elav.PU>Hsap\MAPTR406W.Scer\UAS induced neuronal apoptosis and locomotory defects.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Isolated as a suppressor of position effect variegation at the w locus in flies carrying In(1)wm4h, and a dominant enhancer of position effect variegation, E(var)c1011.

External Crossreferences and Linkouts ( 1 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (8)
References (17)