eIF4G, eIF-4G, eukaryotic translation initiation factor 4G, Eukaryotic-initiation-factor-4G, deIF4G
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4G1 using the Feature Mapper tool.
eIF4G1 protein is expressed primarily in somatic cyst cells. eIF4G1 protein can also be detected at lower levels in germ cells at some stages of spermatogeneis; it is localized to the cytoplasm of spermatogonia and primary spermatocytes, but is excluded from meiotic and post-meiotic stage germ cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\eIF4G1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Candidate stable intronic sequence RNA (sisRNA) identified within CDS of this gene.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Drosophila initiation factor eIF-4F is composed of two subunits, one is encoded by eIF-4E and the other by eIF-4G, a 200kD protein. eIF-4G is required for the translation of endogenous mRNAs in cell-free systems made from Drosophila embryos, and can cross-link uncapped, but not m7G capped RNA. eIF-4E cross-links with m7G capped RNA.