FlyBase Allele Report: Dmel\eIF4E1[S071513]

General Information

Symbol

Dmel\eIF4E1^S071513

Species

D. melanogaster

Name

FlyBase ID

FBal0175695

Feature type

allele

Associated gene

Dmel\eIF4E1

Associated Insertion(s)

P{lacW}eIF4E1^S071513

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{lacW}eIF4E1^S071513

Cytology

Description

Insertion of P{lacW} at nucleotide position +1282 (coordinates according to FBrf0088373).

(Lachance et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:9,401,189..9,401,189

(Lachance et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Lachance et al., 2002)

abnormal developmental rate, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

lethal | embryonic stage | recessive

(Lachance et al., 2002)

lethal | larval stage | recessive

(Lachance et al., 2002)

partially lethal, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

visible, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

Phenotype Manifest In

wing, with eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

Detailed Description

Statement

Reference

18% of embryos fail to hatch. For those that do hatch, development is arrested in the first larval instar, although the larvae survive for several days. Developmental delay with eIF-4E^{Ser251Ala.t8.9} is 3 to 4 days.

(Lachance et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

eIF4E1^S058911

(Lachance et al., 2002)

eIF4E1^67Af

(Lachance et al., 2002)

eIF4E1⁰⁷²³⁸

(Lachance et al., 2002)

Rescued by

eIF4E1^S071513 is rescued by eIF4E1^+t8.9

(Lachance et al., 2002)

eIF4E1^S071513 is rescued by eIF4E1^{Ser251Asp.t8.9}

(Lachance et al., 2002)

Partially rescued by

eIF4E1^S071513 is partially rescued by eIF4E1^{Ser251Ala.t8.9}

(Lachance et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Relatively strong allele.

(Lachance et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

eIF-4E^715/13

(Lachance et al., 2002)

eIF-4E^S071513

eIF4E1^S071513

l(3)715/13

(Lachance et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close