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General Information
Symbol
Dmel\trcK122A.UAS.L.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0246461
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: K122A.

UASt regulatory sequences drive expression of a mutated form of the long isoform of trc with the above amino acid substitution. This mutation is at a residue in the active site of the expressed product and therefore should destroy the kinase activity of the enzyme.

Construct: Amino acid replacement: K122A.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

multidendritic neuron & dendrite, with Scer\GAL4477

multidendritic neuron & dendrite | supernumerary, with Scer\GAL4477

Detailed Description
Statement
Reference

When trcK122A.Scer\UAS.T:Zzzz\FLAG is driven by Scer\GAL4477 a highly penetrant increase in terminal branches is seen in ddaC dendrites. Tiling defects are also seen.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

Scer\GAL4477, trcK122A.UAS.L.Tag:FLAG/trcK122A.Scer\UAS.T:Zzzz\FLAG has multidendritic neuron & dendrite | supernumerary phenotype, non-enhanceable by Rac1N17.UAS, Scer\GAL4477

Scer\GAL4477, trcK122A.UAS.L.Tag:FLAG/trcK122A.Scer\UAS.T:Zzzz\FLAG has multidendritic neuron & dendrite phenotype, non-enhanceable by Rac1N17.UAS, Scer\GAL4477

Suppressed by
NOT suppressed by
Statement
Reference

Scer\GAL4477, trcK122A.UAS.L.Tag:FLAG/trcK122A.Scer\UAS.T:Zzzz\FLAG has multidendritic neuron & dendrite | supernumerary phenotype, non-suppressible by Rac1N17.UAS, Scer\GAL4477

Scer\GAL4477, trcK122A.UAS.L.Tag:FLAG/trcK122A.Scer\UAS.T:Zzzz\FLAG has multidendritic neuron & dendrite phenotype, non-suppressible by Rac1N17.UAS, Scer\GAL4477

Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of trcK122A.Scer\UAS.T:Zzzz\FLAG enhances the defects in flight ability caused by expression of Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW.

The abnormal wing posture phenotype seen in flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is enhanced by co-expression of trcK122A.Scer\UAS.T:Zzzz\FLAG.

The ability of trcK122A.Scer\UAS.T:Zzzz\FLAG to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is blocked by co-expression of either MarfmiRNA.cUa.Scer\UAS or Atg1Scer\UAS.cSa.

The ability of trcK122A.Scer\UAS.T:Zzzz\FLAG to enhance the abnormal wing posture phenotype seen in flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is partially suppressed by co-expression of MiroKK102189.

trcK122A.Scer\UAS.T:Zzzz\FLAG suppresses the overbranching phenotype seen in trcK122A.Scer\UAS.T:Zzzz\FLAG, Scer\GAL4477 animals but not the tiling defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
trcK122A.Scer\UAS.L.T:Zzzz\FLAG
trcK122A.Scer\UAS.T:Zzzz\FLAG
trcK122A.Scer\UAS
trcK122A.UAS.L.Tag:FLAG
trcK122A
Name Synonyms
Secondary FlyBase IDs
  • FBal0177399
  • FBal0215629
References (4)