FlyBase Allele Report: Dmel\lt[RNAi.UAS.cUa]

General Information

Symbol

Dmel\lt^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0322837

Feature type

allele

Associated gene

Dmel\lt

Associated Insertion(s)

Carried in Construct

P{UAS-lt.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-lt.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi line that targets lt.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Nicolson et al., 2024)

embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Umargamwala et al., 2025)

eye, with Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

gastric caecum | larval stage, with Scer\GAL4^unspecified

(Nicolson et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has abnormal eye color | adult stage phenotype, enhanceable by Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has abnormal eye color phenotype, enhanceable by Hsap\ZNRF1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has abnormal eye color phenotype, enhanceable by Hsap\ZNRF2^UAS.cBa, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has abnormal eye color phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has visible phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has abnormal eye color phenotype, suppressible | partially by Atg1^GD7149, Scer\GAL4^GMR.PF

(Nicolson et al., 2024)

Enhancer of

Statement

Reference

lt^RNAi.UAS.cUa, Scer\GAL4^GMR.PF is an enhancer of abnormal eye color | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

NOT Enhancer of

Statement

Reference

lt^RNAi.UAS.cUa, Scer\GAL4^GMR.PF is a non-enhancer of decreased size | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Suppressor of

Statement

Reference

lt^RNAi.UAS.cUa/Scer\GAL4^mex1.2.1 is a suppressor of decreased size | larval stage phenotype of detr¹

(Nicolson et al., 2024)

NOT Suppressor of

Statement

Reference

lt^RNAi.UAS.cUa, Scer\GAL4^GMR.PF is a non-suppressor of decreased size | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, lt^RNAi.UAS.cUa has eye phenotype, suppressible | partially by detr¹

(Nicolson et al., 2024)

Suppressor of

Statement

Reference

lt^RNAi.UAS.cUa/Scer\GAL4^mex1.2.1 is a suppressor of gastric caecum | larval stage phenotype of detr¹

(Nicolson et al., 2024)

lt^RNAi.UAS.cUa, Scer\GAL4^Mef2.PU is a suppressor of larval somatic muscle cell | third instar larval stage phenotype of FIG4^{RNAi.RNAi.cBa}, Scer\GAL4^Mef2.PU

(Bharadwaj et al., 2016)

lt^RNAi.UAS.cUa, Scer\GAL4^Mef2.PU is a suppressor of lysosome | third instar larval stage phenotype of FIG4^{RNAi.RNAi.cBa}, Scer\GAL4^Mef2.PU

(Bharadwaj et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The lysosome expansion phenotype observed in third instar larvae expressing FIG4^{dsRNA.miRNA.Scer\UAS} under the control of Scer\GAL4^Mef2.PU is suppressed by co-expression of lt^{dsRNA.Scer\UAS.cUa}.

(Bharadwaj et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

lt^RNAi.UAS.cUa

lt^{dsRNA.Scer\UAS.cUa}

lt^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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