FlyBase Allele Report: Dmel\Mi-2[HMC03329]

General Information

Symbol

Dmel\Mi-2^HMC03329

Species

D. melanogaster

Name

FlyBase ID

FBal0292492

Feature type

allele

Associated gene

Dmel\Mi-2

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03329}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03329}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03329

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^fl.SCA3.UAS

(Ashraf et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell size | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Umargamwala et al., 2025)

increased size | adult stage, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

visible | adult stage, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Phenotype Manifest In

chromosome | adult stage | female, with Scer\GAL4^{VP16.mat.αTub67C}

(Nikalayevich and Ohkura, 2015)

embryonic/larval midgut cell | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Umargamwala et al., 2025)

eye, with Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

oocyte, with Scer\GAL4^{VP16.mat.αTub67C}

(Nikalayevich and Ohkura, 2015)

Detailed Description

Statement

Reference

Expression of Mi-2^HMC03329 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in significantly increased frequency of undercondensed chromosomes in mature oocytes compared to controls.

(Nikalayevich and Ohkura, 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Mi-2^HMC03329, Scer\GAL4^GMR.PF is a non-enhancer of decreased size | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Suppressor of

Statement

Reference

Mi-2^HMC03329, Scer\GAL4^GMR.PF is a suppressor | partially of abnormal eye color | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

NOT Suppressor of

Statement

Reference

Mi-2^HMC03329, Scer\GAL4^GMR.PF is a non-suppressor of decreased size | adult stage phenotype of Atg1^UAS.cSa, Scer\GAL4^GMR.PF

(Umargamwala et al., 2025)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

51774

y¹ v¹; P{TRiP.HMC03329}attP40

NIG-Fly

HMC03329

y¹ v¹; P{TRiP.HMC03329}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Mi-2^HMC03329

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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