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General Information
Symbol
Dmel\Atg13UAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Chang
FlyBase ID
FBal0221503
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Atg13
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Atg13 cDNA LD09558.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

The amelioration of the phenotype in Npc1aKK101077 expressing flies is observed upon simultaneous co-expression of both Atg1Scer\UAS.cSa and Atg13Scer\UAS.cCa. sf161013

Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Atg13Scer\UAS.cCa under the control of Scer\GAL4Cg.PA does not induce formation of autophagic vesicles (as detected by Atg8a signal).

Expression of Atg13Scer\UAS.cCa under the control of Scer\GAL4Act5C.PP in fat body cell clones has no appreciable effect on cell size.

Expression of Atg13Scer\UAS.cCa under the control of Scer\GAL4GMR.PF has no discernible effect on eye development.

Expression of Atg13Scer\UAS.cCa under the control of Scer\GAL4Cg.PA does not affect larval growth or developmental timing.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The formation of autophagic vesicles (as detected by Atg8a signal) in the fat body of well-fed larvae induced by expression of AdukScer\UAS.cBa under the control of Scer\GAL4Cg.PA is prevented by co-expression of Atg13Scer\UAS.cCa.

The pupariation delay and increased pupal size observed in flies expressing Npc1aKK101077 under the Scer\GAL4P0206 driver is rescued by simultaneous co-expression of Atg1Scer\UAS.cSa and Atg13Scer\UAS.cCa.

Co-expression of Atg13Scer\UAS.cCa results in a marked increase in the number, size, and distribution of autophagosomes in animals expressing Atg1Scer\UAS.T:Hsap\MYC under the control of low levels of Scer\GAL4hs.PB (using a 1 hour heat shock).

Co-expression of Atg13Scer\UAS.cCa and Atg1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Act5C.PP in fat body cell clones results in cells that are markedly reduced in size compared to neighbouring control cells.

Co-expression of Atg13Scer\UAS.cCa and Atg1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF leads to disruption of ommatidial patterning.

Co-expression of Atg13Scer\UAS.cCa and Atg1Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Cg.PA leads to a growth and developmental arrest at the first instar stage of development.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Atg13Scer\UAS.cCa
Atg13UAS.cCa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Chang
Secondary FlyBase IDs
    References (3)