FB2025_05 , released December 11, 2025
Allele: Dmel\srlKK100201
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General Information
Symbol
Dmel\srlKK100201
Species
D. melanogaster
Name
FlyBase ID
FBal0230612
Feature type
allele
Associated gene
Dmel\srl
Associated Insertion(s)
Carried in Construct
P{KK100201}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK100201}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK100201
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Ng et al., 2017)
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of srlKK100201 under the control of Scer\GAL4how-24B leads to fragmentation of mitochondria in flight muscle, as compared to controls.

      Expression of srlKK100201 under the control of Scer\GAL4Ddc.PL leads to loss of dopaminergic neurons in the PPL1 cluster, a significant decrease in mitochondrial size in dopaminergic neurons, and fragmentation of mitochondria in flight muscle; but does not result in any apparent climbing defects, as compared to controls.

      (Ng et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of LamCUAS.cSa and srlKK100201 under the control of Scer\GAL4fln.IFM does not lead to any obvious indirect flight muscle, wing posture or flight defects.

      (Chandran et al., 2019)

      Co-expression of AMPKαTD.Scer\UAS fails to suppress the dopaminergic neuron loss seen in flies expressing srlKK100201 under the control of Scer\GAL4Ddc.PL, and additionally leads to climbing defects in these flies, as compared to controls.

      (Ng et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of both srlKK100201 and AMPKαTD.Scer\UAS fails to rescue the climbing defects and loss of dopaminergic neurons seen in flies expressing Hsap\LRRK2G2019S.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Ddc.PL.

      (Ng et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SpargelKK100201
      srlKK100201
      Name Synonyms
      Secondary FlyBase IDs
        References (9)