FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LamCunspecified
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General Information
Symbol
Dmel\LamCunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0326477
Feature type
allele
Associated gene
Dmel\LamC
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  progeria
        CEA with LamCE174K.UAS
        (Li et al., 2016)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The expression of LamCE174K.Scer\UAS, but not LamCScer\UAS.cLa, under the control of Scer\GAL4Mhc.PW in LamCunspecified heterozygotes results in a range of defects in dorsal longitudinal indirect flight muscles: thinner myofibrils and sarcomere disorganization (with vanishing Z lines and A bands) at 21, but not at 4, days post eclosion; progressive mitochondrion defects, as shown by a significant decrease in the relative mitochondrial volume, sparser distribution, smaller and rounder morphology, collapsing or disintegrating cristae, and significant and progressive decrease of the electron density of mitochondria in electron miscroscopy images, at 14 and 21, but not at 3, days post eclosion; and a significant increase in cytoplasmic polyubiquitin aggregates at 14, but not 3, days post eclosion, as compared to controls. Individuals expressing LamCE174K.Scer\UAS, but not LamCScer\UAS.cLa, under the control of Scer\GAL4Mhc.PW also exhibit a "wings-up" phenotype and flight defects, as shown by a significant decrease in landing height, at 21 but not at 4 days post eclosion, as compared to controls.

        The expression of LamCE174K.Scer\UAS, but not of either LamCScer\UAS.cLa or LamCR564C.Scer\UAS, under the control of Scer\GAL4BG487 in LamCunspecified heterozygotes leads to a strong increase in the number of nuclei exhibiting more than 10 abnormal lamina blebs in third instar larval muscles 6 and 7, as compared to controls.

        (Li et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The dorsal longitudinal indirect flight muscles of LamCunspecified heterozygotes expressing LamCE174K.Scer\UAS under the control of Scer\GAL4Mhc.PW exhibit both increased cytoplasmic polyubiquitin aggregates (at 14 days post eclosion) and mitochondrial defects (abnormal morphology, decreased mitochondrial volume and decreased electron density of mitochondria in electron microscopy images, at 14 and 21 days post eclosion, respectively), which are partially suppressed and not suppressed, respectively, by the co-expression of MarfScer\UAS.T:Ivir\HA1.

        (Li et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        LamCunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (2)