FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\kaybZip.UAS
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General Information
Symbol
Dmel\kaybZip.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0089168
Feature type
allele
Associated gene
Dmel\kay
Associated Insertion(s)
Carried in Construct
P{UAS-kay.bZip}
Also Known As
UAS-fosbZIP
Key Links
Transgenic product class
inframe_deletion
(Zeitlinger et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zeitlinger et al., 1997)
Mutagen
in vitro construct
(Zeitlinger et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-kay.bZip}
Cytology
Description

The basic and leucine zipper regions of kay are expressed under the control of UASt regulatory sequences.

(Zeitlinger et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
kay
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of kaybZip.Scer\UAS under the control of Scer\GAL4pnr-MD237 results in a strong cleft thorax phenotype. However, when kaybZip.Scer\UAS is expressed under the control of Scer\GAL4how-24B, no thoracic phenotype is visible.

      Expression of kaybZip.Scer\UAS under the control of Scer\GAL4ey.PH results in the development of small rough eyes.

      (Cerrato et al., 2006)

      Expression of kaybZip.Scer\UAS under the control of Scer\GAL4pnr-MD237 or Scer\GAL4ap-md544 results in the appearance of a cleft in the thorax.

      (Zeitlinger and Bohmann, 1999)

      Animals expressing kaybZip.Scer\UAS under the control of Scer\GAL4C-765 develop to late embryonic stages and die with a dorsal anterior hole.

      (Zeitlinger et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Scer\GAL4ey.PH, kaybZip.UAS has eye phenotype, suppressible by Scer\GAL4ey.PH, kaybZip.UAS

      (Cerrato et al., 2006)
      Suppressor of
      Other
      Statement
      Reference

      Mnn1[+]/Mnn1Δ46, Scer\GAL4how-24B, kaybZip.UAS has adult thorax phenotype

      (Cerrato et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The border follicle cell migration defects that are seen in flies co-expressing both PvrDN.Scer\UAS and hepAct.Scer\UAS under the control of Scer\GAL4slbo.2.6 are partially suppressed by the co-expression of kaybZip.Scer\UAS.

      (Mathieu et al., 2007)

      Expression of kaybZip.Scer\UAS under the control of Scer\GAL4how-24B in a Mnn1Δ46/+ background results in a moderate thoracic cleft phenotype, while no phenotype is observed in a wild-type background. Scer\GAL4how-24B>kaybZip.Scer\UAS expression in a Mnn1Δ46/Mnn1Δ79 background results in pre-pupal lethality.

      Coexpression of Mnn1Scer\UAS.cCa with kaybZip.Scer\UAS, under the control of Scer\GAL4ey.PH, results in complete suppression of the Scer\GAL4ey.PH>kaybZip.Scer\UAS rough eye phenotype.

      (Cerrato et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kaybZip.Scer\UAS
      kaybZip.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (7)