FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mnn1Δ46
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General Information
Symbol
Dmel\Mnn1Δ46
Species
D. melanogaster
Name
FlyBase ID
FBal0198138
Feature type
allele
Associated gene
Dmel\Mnn1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Cerrato et al., 2006)

amorphic allele - molecular evidence

(Sturgill et al., 2007)
Mutagen
Delta2-3 transposase
(Cerrato et al., 2006)
Progenitor genotype
P{wHy}Mnn1DG30701
(Cerrato et al., 2006)
Cytology
Description

Imprecise excision of the P{wHy} element resulting in the deletion of 186bp of the Mnn1 gene, including 70bp downstream of the first ATG and complete removal of the P{wHy} insertion.

(Cerrato et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  multiple endocrine neoplasia type 1
      CEA
      (Cerrato et al., 2006)
      CEA with Mnn1Δ79
      (Cerrato et al., 2006)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mnn1Δ46 and Mnn1Δ46/Mnn1Δ79 males show a constant rate of early mortality in days 1-30. These flies also appear to be slightly more resistant to the herbicide paraquat, although this is in contrast to previous reports of other Mnn1 mutants showing increased sensitivity to paraquat.

      (Cerrato et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      Mnn1[+]/Mnn1Δ46, Scer\GAL4how-24B, kaybZip.UAS has adult thorax phenotype

      (Cerrato et al., 2006)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of kaybZip.Scer\UAS under the control of Scer\GAL4how-24B in a Mnn1Δ46/+ background results in a moderate thoracic cleft phenotype, while no phenotype is observed in a wild-type background. Scer\GAL4how-24B>kaybZip.Scer\UAS expression in a Mnn1Δ46/Mnn1Δ79 background results in pre-pupal lethality.

      (Cerrato et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mnn1Δ46
      mnn1Δ46
      (Sturgill et al., 2007, Cerrato et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)