FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Fkbp14
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General Information
Symbol
Dmel\Fkbp14
Species
D. melanogaster
Name
FK506-binding protein 14
Annotation Symbol
CG9847
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010470
Gene Model Status
Current
Stock Availability
19 publicly available
Enzyme Name (EC)
peptidylprolyl isomerase (5.2.1.8)
Gene Summary
FK506-binding protein 14 (Fkbp14) encodes an ER resident protein and a member of the large FKBP family of immunophilins. It plays an essential role in development, including stabilizing the protein encoded by Psn in the ER. Fkbp14 mutants genetically interact with components of the Notch pathway. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Fkbp13, l(2)00734, BcDNA.GM07659

Key Links
Genomic Location
Cytogenetic map
57E6-57E6
Sequence location
Recombination map
2-95
RefSeq locus
NT_033778 REGION:21487167..21497929
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR002048
(InterPro Project Members, 2004-)
enables peptidyl-prolyl cis-trans isomerase activity
inferred from biological aspect of ancestor with PANTHER:PTN000054106
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001179, InterPro:IPR046357
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in chaeta development
inferred from mutant phenotype
(van de Hoef et al., 2013)
involved_in imaginal disc development
inferred from mutant phenotype
(van de Hoef et al., 2013)
involved_in imaginal disc-derived wing margin morphogenesis
inferred from mutant phenotype
(van de Hoef et al., 2013)
involved_in muscle cell cellular homeostasis
inferred from mutant phenotype
(Kucherenko et al., 2011)
inferred from genetic interaction with FLYBASE:Dg; FB:FBgn0034072
(Kucherenko et al., 2011)
involved_in positive regulation of Notch signaling pathway
inferred from genetic interaction with FLYBASE:Delta; FB:FBgn0000463
(van de Hoef et al., 2013)
inferred from genetic interaction with FLYBASE:Psn; FB:FBgn0284421
(van de Hoef et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum
inferred from direct assay
(van de Hoef et al., 2013, Tan et al., 2009)
located_in extracellular space
inferred from direct assay
(Walker et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in endoplasmic reticulum
inferred from biological aspect of ancestor with PANTHER:PTN000054106
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
peptidyl-prolyl cis-trans isomerase activity
[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (5.2.1.8)
RHEA 16237:
Summaries
Gene Snapshot
FK506-binding protein 14 (Fkbp14) encodes an ER resident protein and a member of the large FKBP family of immunophilins. It plays an essential role in development, including stabilizing the protein encoded by Psn in the ER. Fkbp14 mutants genetically interact with components of the Notch pathway. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
FK506-BINDING PROTEINS -
FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)
Pathway (FlyBase)
POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY -
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Fkbp14 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4K7C5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Fkbp14-RA
FBtr0071703
NM_057625
1299
216
Fkbp14-RC
FBtr0300397
NM_166452
1301
216
Fkbp14-RD
FBtr0306013
NM_001259519
1311
220
Fkbp14-RE
FBtr0342896
NM_001299750
1294
216
Fkbp14-RF
FBtr0342897
NM_001299751
1350
216
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Fkbp14-PA
FBpp0071620
24.0
216
4.49
Q9V3V2
NP_476973
AAF46726
Fkbp14-PC
FBpp0289626
24.0
216
4.49
Q9V3V2
NP_726074
AAM70900
Fkbp14-PD
FBpp0297155
24.4
220
4.49
A0A0B4K7C5
NP_001246448
AFH08201
Fkbp14-PE
FBpp0309697
24.0
216
4.49
Q9V3V2
NP_001286679
AHN56474
Fkbp14-PF
FBpp0309698
24.0
216
4.49
Q9V3V2
NP_001286680
AHN56475
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

216 aa isoforms: Fkbp14-PA, Fkbp14-PC, Fkbp14-PE, Fkbp14-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fkbp14 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.87

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in endoplasmic reticulum
inferred from direct assay
(van de Hoef et al., 2013, Tan et al., 2009)
located_in extracellular space
inferred from direct assay
(Walker et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fkbp14 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Fkbp14
Transgenic constructs containing regulatory region of Fkbp14
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | larval stage | somatic clone
lethal (with Fkbp14D58)
lethal (with Fkbp14EP2019)
lethal (with Fkbp14EP2206)
lethal | recessive
lethal - all die before end of P-stage
partially lethal (with Df(2R)Exel6076)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile | germline clone
fertile
Other Phenotypes
Allele
abnormal behavior | recessive
abnormal locomotor behavior | adult stage | male limited
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal starvation stress response
abnormal temperature response | female limited
long lived | male limited
Phenotype manifest in
Allele
imaginal disc
indirect flight muscle cell, with Scer\GAL4Tub.PU
mesothoracic bristle | pharate adult stage
notal microchaeta | pharate adult stage
sensory mother cell | third instar larval stage
synapse, with Scer\GAL4elav-C155
wing disc | third instar larval stage
wing margin | pharate adult stage
wing margin bristle | pharate adult stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (16)
Hsap\FKBP14
12 of 14
Yes
Yes
1  
Hsap\FKBP7
8 of 14
No
Yes
1  
Hsap\FKBP2
4 of 14
No
No
Hsap\FKBP9
3 of 14
No
Yes
Hsap\FKBP10
3 of 14
No
Yes
1  
Hsap\FKBP11
3 of 14
No
No
Hsap\FKBP1A
2 of 14
No
No
2  
Hsap\FKBP1B
2 of 14
No
No
Hsap\FKBP4
2 of 14
No
No
Hsap\FKBP5
2 of 14
No
No
Hsap\FKBP6
2 of 14
No
No
1  
Hsap\FKBP15
2 of 14
No
No
1  
Hsap\FKBP1C
1 of 14
No
No
Hsap\FKBP3
1 of 14
No
No
Hsap\FKBP8
1 of 14
No
No
Hsap\FKBP9P1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (12)
Rnor\Fkbp14
12 of 14
Yes
Yes
Rnor\Fkbp7
9 of 14
No
Yes
Rnor\Fkbp2
5 of 14
No
No
Rnor\Fkbp9
3 of 14
No
Yes
Rnor\Fkbp10
3 of 14
No
Yes
Rnor\Fkbp1a
2 of 14
No
No
Rnor\Fkbp1b
2 of 14
No
No
Rnor\Fkbp3
2 of 14
No
No
Rnor\Fkbp4
2 of 14
No
No
Rnor\Fkbp5
2 of 14
No
No
Rnor\Fkbp6
2 of 14
No
No
Rnor\Fkbp11
1 of 14
No
Yes
Mus musculus (laboratory mouse) (14)
Mmus\Fkbp14
12 of 14
Yes
Yes
Mmus\Fkbp7
8 of 14
No
Yes
Mmus\Fkbp2
4 of 14
No
No
Mmus\Fkbp9
3 of 14
No
Yes
Mmus\Fkbp10
3 of 14
No
Yes
Mmus\Fkbp11
3 of 14
No
No
Mmus\Fkbp1a
2 of 14
No
No
Mmus\Fkbp1b
2 of 14
No
No
Mmus\Fkbp3
2 of 14
No
No
Mmus\Fkbp4
2 of 14
No
No
Mmus\Fkbp5
2 of 14
No
No
Mmus\Fkbp6
2 of 14
No
No
Mmus\Fkbp8
1 of 14
No
No
Mmus\Fkbp15
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\fkbp7
8 of 13
Yes
Yes
Xtro\fkbp14
7 of 13
No
Yes
Xtro\fkbp2
3 of 13
No
No
Xtro\fkbp9
2 of 13
No
Yes
Xtro\fkbp11
2 of 13
No
No
Xtro\fkbp1b
1 of 13
No
No
Xtro\fkbp3
1 of 13
No
No
Xtro\fkbp4
1 of 13
No
No
Xtro\fkbp10
1 of 13
No
Yes
Xtro\LOC100492768
1 of 13
No
No
Xtro\mtus2
1 of 13
No
Yes
Danio rerio (Zebrafish) (18)
Drer\fkbp14
12 of 14
Yes
Yes
Drer\fkbp7
8 of 14
No
Yes
Drer\fkbp2
5 of 14
No
No
Drer\fkbp9
3 of 14
No
Yes
Drer\fkbp10b
3 of 14
No
Yes
Drer\fkbp11
3 of 14
No
No
Drer\fkbp1aa
2 of 14
No
No
Drer\fkbp1ab
2 of 14
No
No
Drer\fkbp1b
2 of 14
No
No
Drer\fkbp4
2 of 14
No
No
Drer\fkbp5
2 of 14
No
No
Drer\fkbp10a
2 of 14
No
Yes
Drer\fkbp3
1 of 14
No
No
Drer\fkbp6
1 of 14
No
No
Drer\fkbp8
1 of 14
No
No
Drer\fkbp15a
1 of 14
No
Yes
Drer\fkbp15b
1 of 14
No
Yes
Drer\fkbp16
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\fkb-1
5 of 14
Yes
No
Cele\fkb-3
3 of 14
No
Yes
Cele\fkb-4
3 of 14
No
Yes
Cele\fkb-2
2 of 14
No
No
Cele\fkb-5
2 of 14
No
Yes
Cele\fkb-6
2 of 14
No
No
Cele\fkb-7
2 of 14
No
Yes
Cele\fkb-8
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP008822
11 of 12
Yes
Yes
Agam\AgaP_AGAP003134
3 of 12
No
No
Agam\AgaP_AGAP006615
2 of 12
No
No
Agam\AgaP_AGAP007473
2 of 12
No
No
Agam\AgaP_AGAP009347
2 of 12
No
No
Agam\AgaP_AGAP012184
2 of 12
No
No
Agam\AgaP_AGAP007666
1 of 12
No
No
Agam\AgaP_AGAP011458
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (26)
Atha\FKBP15-1
8 of 13
Yes
No
Atha\FKBP15-2
8 of 13
Yes
No
Atha\AT5G05420
3 of 13
No
No
Atha\FKBP13
3 of 13
No
No
Atha\AT1G18170
2 of 13
No
Yes
Atha\AT1G20810
2 of 13
No
Yes
Atha\AT1G73655
2 of 13
No
Yes
Atha\AT2G43560
2 of 13
No
Yes
Atha\AT3G10060
2 of 13
No
Yes
Atha\AT3G12340
2 of 13
No
No
Atha\AT3G55520
2 of 13
No
No
Atha\AT3G60370
2 of 13
No
Yes
Atha\AT4G19830
2 of 13
No
Yes
Atha\AT5G13410
2 of 13
No
Yes
Atha\AT5G48570
2 of 13
No
No
Atha\FKBP12
2 of 13
No
No
Atha\FKBP53
2 of 13
No
No
Atha\PAS1
2 of 13
No
No
Atha\PnsL4
2 of 13
No
No
Atha\ROF1
2 of 13
No
No
Atha\AT3G03400
1 of 13
No
No
Atha\AT3G12345
1 of 13
No
Yes
Atha\AT4G26555
1 of 13
No
Yes
Atha\CML30
1 of 13
No
Yes
Atha\TPR7
1 of 13
No
No
Atha\TWD1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\FPR2
6 of 13
Yes
No
Scer\FPR1
2 of 13
No
No
Scer\FPR3
2 of 13
No
No
Scer\FPR4
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\fkbp39
2 of 12
Yes
No
Spom\fkh1
2 of 12
Yes
No
Spom\SPAC27F1.06c
2 of 12
Yes
No
Escherichia coli (enterobacterium) (4)
Ecol\fkpA
4 of 11
Yes
No
Ecol\fklB
3 of 11
No
No
Ecol\fkpB
1 of 11
No
Yes
Ecol\slyD
1 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Fkbp14. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
CG14715
7 of 13
Fkbp12
3 of 13
Fkbp39
2 of 13
Fkbp59
2 of 13
CG30075
1 of 13
rdgC
1 of 13
shu
1 of 13
zda
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Fkbp1400734
    exacerbates  muscular dystrophy
    modeled by Dg323
    (Kucherenko et al., 2011)
    modeled by DgO86
    (Kucherenko et al., 2011)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FKBP14; FKBP prolyl isomerase 14
    12 of 14
    614505
     
    FKBP7; FKBP prolyl isomerase 7
    8 of 14
    607062
         
        FKBP2; FKBP prolyl isomerase 2
        4 of 14
        186946
            FKBP9; FKBP prolyl isomerase 9
            3 of 14
            616257
                FKBP10; FKBP prolyl isomerase 10
                3 of 14
                607063
                 
                FKBP11; FKBP prolyl isomerase 11
                3 of 14
                610571
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    Fkbp14 - Acaa
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Akap200
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Aldo
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - AnxB10
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Ar1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Ar2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Ar4
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Ar5
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Bacc
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG11267
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG14715
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG2852
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG4598
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG5174
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG5355
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG8209
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG8993
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - CG9705
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Calr
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Chd64
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Cs1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Df31
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - EndoGI
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Eno
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Fkbp12
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Glo1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - GstE6
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - GstO3
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - GstT1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Gtpx
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - HINT1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Hsp110
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Inos
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Jupiter
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Mdh2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Moe
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Nacα
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Nlp
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Ntf-2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Nurf-38
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - PCNA
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Pdi
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Pgam1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Pgd
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Pgk
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Prosα4
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Prx6c
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - RhoGDI
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Sh3β
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Sumo
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Taldo
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Tkt
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Trx2
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Trxr1
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - Uch
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - awd
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - capt
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - chic
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - cib
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - dUTPase
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - dj-1β
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - eEF5
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - fabp
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - regucalcin
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - scf
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Fkbp14 - scu
                    experimental knowledge based
                    (Guruharsha et al., 2011)
                    Summary of Genetic Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Delta
                    enhanceable
                    Fkbp14
                    (van de Hoef et al., 2013)
                    Jra|kay
                    suppressible
                    Fkbp14
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    Fkbp14
                    (Franciscovich et al., 2008)
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    External Data
                    Linkouts
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2R
                    Recombination map
                    2-95
                    Cytogenetic map
                    57E6-57E6
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    57E6-57E6
                    Limits computationally determined from genome sequence between P{PZ}tmx1&P{EP}MESK2EP2347 and P{PZ}Egfr05351
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    57E3-57E4
                    (determined by in situ hybridisation)
                    (Spradling et al., 1999)
                    57E3-57E4
                    (BDGP Project Members, 1994-1999)
                    Experimentally Determined Recombination Data
                    Location

                    2-95

                    (FlyBase, 2016)

                    2-101.5

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (19)
                    Genomic Clones (18)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (69)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (van de Hoef et al., 2013)
                    Commercially Available Antibodies
                     
                    Cell Line Information
                    Publicly Available Cell Lines
                     
                      Other Stable Cell Lines
                       
                        Other Comments
                        Relationship to Other Genes
                        Source for database merge of

                        Source for merge of: Fkbp13 BcDNA:GH08925 BcDNA:GM07659

                        (FlyBase, 1996-)
                        Additional comments

                        Source for merge of Fkbp13 BcDNA:GH08925 BcDNA:GM07659 was sequence comparison ( date:990717 ).

                        (FlyBase, 1996-)
                        Nomenclature History
                        Source for database identify of

                        Source for identity of: Fkbp14 Fkbp13

                        (van de Hoef et al., 2013)
                        Nomenclature comments

                        FlyBase curator comment: Originally named 'Fkbp13' (FBrf0111489) but here shown to be closer to mammalian FKBP14, so re-named accordingly.

                        (van de Hoef et al., 2013)
                        Etymology
                        Synonyms and Secondary IDs (14)
                        Reported As
                        Symbol Synonym
                        BcDNA.GM07659
                        (de Morais Guedes et al., 2003, Tsang, 1999.3.2)
                        BcDNA:GH08925
                        BcDNA:GM07659
                        CG9847
                        (National Institute of Genetics Fly Stocks, 2022-, Ghartey-Kwansah et al., 2018, Misra et al., 2014, van de Hoef et al., 2013, Cammarato et al., 2011, Perkins et al., 2009, Haussmann et al., 2008, Grieder et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Walker et al., 2006)
                        FKB13
                        (Johnson et al., 2004)
                        FKBP13
                        (Vinci et al., 2008, Bokel et al., 2006, Bokel et al., 2006)
                        FKBP14
                        (Ghartey-Kwansah et al., 2018, van de Hoef et al., 2013)
                        Fkbp13
                        (Aradska et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Kucherenko et al., 2011, Marrone et al., 2011, Magwire et al., 2010, Nagoshi et al., 2010, Edwards et al., 2009, Tan et al., 2009, Tan et al., 2009, Franciscovich et al., 2008, Zhang et al., 2008, Buszczak et al., 2007, Grieder et al., 2007, Quinones-Coello, 2007, Ravi Ram and Wolfner, 2007, Molnar et al., 2006, Morozova et al., 2006, Walker et al., 2006, Wang et al., 2006, Brown and Feder, 2005)
                        Fkbp14
                        (Kang et al., 2025, Rommelaere et al., 2025, Floc'hlay et al., 2023, Cassella and Ephrussi, 2022, Jevitt et al., 2020, Kockel et al., 2019, Lee et al., 2018, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-)
                        GM07659
                        (Bryant et al., 1999)
                        fkbp13
                        (Vonhoff and Keshishian, 2017, Franciscovich et al., 2008)
                        l(2)00734
                        (Beaton, 2000.1.31, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
                        Name Synonyms
                        FK506-binding protein 14
                        FK506-binding protein 14 ortholog
                        Fkbp13
                        (Cammarato et al., 2011)
                        Secondary FlyBase IDs
                        • FBgn0027068
                        • FBgn0064945
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (0)
                        Result
                        Result Type
                        Title
                        External Crossreferences and Linkouts ( 74 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                        FlyMine - An integrated database for Drosophila genomics
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        MARRVEL_MODEL - MARRVEL (model organism gene)
                        Linkouts
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        References (99)