FlyBase Gene Report: Dmel\Fkbp14

General Information

Symbol

Dmel\Fkbp14

Species

D. melanogaster

Name

FK506-binding protein 14

Annotation Symbol

CG9847

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010470

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

FK506-binding protein 14 (Fkbp14) encodes an ER resident protein and a member of the large FKBP family of immunophilins. It plays an essential role in development, including stabilizing the protein encoded by Psn in the ER. Fkbp14 mutants genetically interact with components of the Notch pathway. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Fkbp13, l(2)00734, BcDNA.GM07659

Key Links

Genomic Location

Cytogenetic map

57E6-57E6

Sequence location

2R:21,487,167..21,497,929 [-]

Recombination map

2-95

RefSeq locus

NT_033778 REGION:21487167..21497929

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables peptidyl-prolyl cis-trans isomerase activity

inferred from electronic annotation with InterPro:IPR001179

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in chaeta development

inferred from mutant phenotype

(van de Hoef et al., 2013)

involved_in imaginal disc development

inferred from mutant phenotype

(van de Hoef et al., 2013)

involved_in imaginal disc-derived wing margin morphogenesis

inferred from mutant phenotype

(van de Hoef et al., 2013)

involved_in muscle cell cellular homeostasis

inferred from mutant phenotype

(Kucherenko et al., 2011)

inferred from genetic interaction with FLYBASE:Dg; FB:FBgn0034072

(Kucherenko et al., 2011)

involved_in positive regulation of Notch signaling pathway

inferred from genetic interaction with FLYBASE:Dl; FB:FBgn0000463

(van de Hoef et al., 2013)

inferred from genetic interaction with FLYBASE:Psn; FB:FBgn0284421

(van de Hoef et al., 2013)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum

inferred from direct assay

(van de Hoef et al., 2013, Tan et al., 2009)

located_in extracellular space

inferred from direct assay

(Walker et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

FK506-BINDING PROTEINS

Pathway (FlyBase)

Positive Regulators of Notch Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

FK506-BINDING PROTEINS -: FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)

Pathway (FlyBase)

Positive Regulators of Notch Signaling Pathway -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Fkbp14 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Fkbp14-RA

FBtr0071703

NM_057625

1299

216

Fkbp14-RC

FBtr0300397

NM_166452

1301

216

Fkbp14-RD

FBtr0306013

NM_001259519

1311

220

Fkbp14-RE

FBtr0342896

NM_001299750

1294

216

Fkbp14-RF

FBtr0342897

NM_001299751

1350

216

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Fkbp14-PA

FBpp0071620

24.0

216

4.49

NP_476973

AAF46726

Fkbp14-PC

FBpp0289626

24.0

216

4.49

NP_726074

AAM70900

Fkbp14-PD

FBpp0297155

24.4

220

4.49

NP_001246448

AFH08201

Fkbp14-PE

FBpp0309697

24.0

216

4.49

NP_001286679

AHN56474

Fkbp14-PF

FBpp0309698

24.0

216

4.49

NP_001286680

AHN56475

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

216 aa isoforms: Fkbp14-PA, Fkbp14-PC, Fkbp14-PE, Fkbp14-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fkbp14 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

plasmatocyte primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic foregut

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

plasmatocyte

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in endoplasmic reticulum

inferred from direct assay

(van de Hoef et al., 2013, Tan et al., 2009)

located_in extracellular space

inferred from direct assay

(Walker et al., 2006)

Expression Deduced from Reporters

Reporter: P{GawB}Fkbp14^NP1122

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

projection neuron | subset

(Masuda-Nakagawa et al., 2010)

embryonic/larval antennal lobe glomerulus | restricted | subset

(Masuda-Nakagawa et al., 2010)

larval mushroom body calyx glomerulus | restricted | subset

(Masuda-Nakagawa et al., 2010)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Fkbp14 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fkbp14

View exonic expression by tissue for Dmel\Fkbp14

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010470

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010470

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9847-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9847

Flygut - An atlas of the Drosophila adult midgut

FBgn0010470

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Fkbp14

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 27 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fkbp14

Transgenic constructs containing regulatory region of Fkbp14

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(2R)48

(Johnson et al., 2004)

Df(2R)Exel6076

(Ryder, 2004.4.26)

Df(2R)Pu-D17

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)XE3030

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | larval stage | somatic clone

Fkbp14^D58

lethal (with Fkbp14^D58)

lethal (with Fkbp14^EP2019)

lethal (with Fkbp14^EP2206)

lethal | recessive

Fkbp14⁰⁰⁷³⁴

lethal - all die before end of P-stage

partially lethal (with Df(2R)Exel6076)

Fkbp14^{MI04530-TG4.2}

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fkbp14^GD4819

viable, with Scer\GAL4^Mef2.PR

Fkbp14^GD4819

viable, with Scer\GAL4^pnr-MD237

Fkbp14^GD4819

viable, with Scer\GAL4^tin.CΔ4

Fkbp14^GD4819

Sterility

Allele

female sterile | germline clone

Fkbp14^D58

fertile

Other Phenotypes

Allele

abnormal behavior | recessive

Fkbp14^BG02644

abnormal locomotor behavior | adult stage | male limited

Fkbp14^BG02644

abnormal neuroanatomy, with Scer\GAL4^elav-C155

Fkbp14^EY02405

abnormal starvation stress response

Fkbp14^BG02644

abnormal temperature response | female limited

Fkbp14^BG02644

long lived | male limited

Fkbp14^BG02644

Phenotype manifest in

Allele

imaginal disc

Fkbp14^D58

indirect flight muscle, with Scer\GAL4^Tub.PU

Fkbp14^VDRC.cUa

mesothoracic bristle | pharate adult stage

notal microchaeta | pharate adult stage

sensory mother cell | third instar larval stage

Fkbp14^D58

synapse, with Scer\GAL4^elav-C155

Fkbp14^EY02405

wing disc | third instar larval stage

Fkbp14^D58

wing margin | pharate adult stage

Fkbp14^D58

wing margin bristle | pharate adult stage

Fkbp14^D58

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\FKBP14

9 of 15

Yes

Hsap\FKBP7

4 of 15

Yes

Hsap\FKBP2

3 of 15

Hsap\FKBP5

2 of 15

Hsap\FKBP9

2 of 15

Yes

Hsap\FKBP10

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Fkbp14

8 of 15

Yes

Mmus\Fkbp7

4 of 15

Yes

Mmus\Fkbp2

3 of 15

Mmus\Fkbp9

2 of 15

Yes

Mmus\Fkbp10

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Fkbp14

9 of 13

Yes

Rnor\Fkbp7

5 of 13

Yes

Rnor\Fkbp2

3 of 13

Rnor\LOC100911857

3 of 13

Yes

Rnor\Fkbp5

2 of 13

Rnor\Fkbp9

2 of 13

Yes

Rnor\Fkbp10

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (12)

Xtro\fkbp14

4 of 12

Yes

Xtro\fkbp7

2 of 12

Yes

Xtro\fkbp9

2 of 12

Yes

Xtro\fkbp10

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (16)

Drer\fkbp14

6 of 15

Yes

Drer\fkbp2

3 of 15

Drer\fkbp9

2 of 15

Yes

Drer\fkbp10b

2 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\fkbp8

1 of 15

Drer\fkbp10a

1 of 15

Yes

Drer\fkbp16

1 of 15

Drer\si:ch211-208h16.4

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (8)

Cele\fkb-1

2 of 15

Yes

Cele\fkb-3

2 of 15

Yes

Cele\fkb-4

2 of 15

Yes

Cele\fkb-5

2 of 15

Yes

Cele\fkb-7

2 of 15

Yes

Cele\fkb-2

1 of 15

Cele\fkb-6

1 of 15

Cele\fkb-8

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\FKBP15-1

4 of 9

Yes

Atha\FKBP15-2

4 of 9

Yes

Atha\FKBP13

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\FPR2

3 of 15

Yes

Scer\FPR1

1 of 15

Scer\FPR3

1 of 15

Scer\FPR4

1 of 15

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190F6I )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA22070

Drosophila persimilis

Dper\GL17491

Drosophila willistoni

Dwil\GK20742

Drosophila virilis

Dvir\GJ22316

Drosophila mojavensis

Dmoj\GI20465

Drosophila grimshawi

Dgri\GH20056

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150D40 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17027295

Glossina morsitans

Tsetse fly

Gmor\GMOY005787

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13967

Mayetiola destructor

Hessian fly

Mdes\Mdes016157

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004313

Anopheles darlingi

American malaria mosquito

Adar\ADAC004406

Anopheles gambiae

Malaria mosquito

Agam\AGAP008822

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009198

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014951

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0EUN )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA000619

Danaus plexippus

Monarch butterfly

Dple\DPOGS206800-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL009249

Apis florea

Little honeybee

Aflo\3320900116

Apis mellifera

Western honey bee

Amel\GB48497

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21038

Bombus terrestris

Buff-tailed bumblebee

Bter\15211326

Linepithema humile

Argentine ant

Lhum\LH21829

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0029d1

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG017550

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_02272

Tribolium castaneum

Red flour beetle

Tcas\TC002441

Pediculus humanus

Human body louse

Phum\PHUM475260

Rhodnius prolixus

Kissing bug

Rpro\RPRC007711

Cimex lectularius

Bed bug

Clec\CLEC001245

Cimex lectularius

Bed bug

Clec\CLEC001243

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003483

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11104

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0KH5 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013885

Strigamia maritima

European centipede

Smar\SMAR013062

Ixodes scapularis

Black-legged tick

Isca\ISCW010191

Ixodes scapularis

Black-legged tick

Isca\ISCW001040

Ixodes scapularis

Black-legged tick

Isca\ISCW002430

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63793.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58382.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g03250

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g06500

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_231271

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_205334

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_231749

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303038

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02W1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fkbp39L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028862gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fk506bp2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fk506bp12

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019756gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_008541gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fkbp12

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fkbp15-2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fkbp15

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022174

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000007014

Ciona intestinalis

Vase tunicate

Cint\LOC100176168

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000015563

Ciona intestinalis

Vase tunicate

Cint\LOC100175378

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018934

Ciona intestinalis

Vase tunicate

Cint\LOC100177303

Gallus gallus

Domestic chicken

Ggal\FKBP14

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000012466

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000008838

Gallus gallus

Domestic chicken

Ggal\FKBP7

Gallus gallus

Domestic chicken

Ggal\FKBP12.6

Gallus gallus

Domestic chicken

Ggal\FKBP9

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000025764

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000027151

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

3 of 10

1 of 10

1 of 10

1 of 10

1 of 10

shu

1 of 10

zda

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Fkbp14⁰⁰⁷³⁴

exacerbates muscular dystrophy

modeled by Dg³²³

(Kucherenko et al., 2011)

modeled by Dg^O86

(Kucherenko et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FKBP14; FKBP prolyl isomerase 14

9 of 15

614505

EHLERS-DANLOS SYNDROME, KYPHOSCOLIOTIC TYPE, 2; EDSKSCL2

FKBP7; FKBP prolyl isomerase 7

4 of 15

607062

FKBP2; FKBP prolyl isomerase 2

3 of 15

186946

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Fkbp14 - Akap200

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Akr1B

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Ald1

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Bacc

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG10638

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG11267

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG14715

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG2767

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG2852

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG4598

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG5174

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG5355

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG8036

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG8209

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG8993

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG9436

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - CG9705

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Calr

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Chd64

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Df31

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - EndoGI

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Eno

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Fkbp12

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Glo1

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - GstE6

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - GstO3

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - GstT1

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - HINT1

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Hsc70Cb

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Inos

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Jupiter

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Mdh2

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Moe

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Nacα

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Nlp

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Ntf-2

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Nurf-38

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - PCNA

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - PHGPx

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Pdi

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Pgd

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Pgk

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Pglym78

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Prosα4

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Prx2540-2

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - RhoGDI

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Sh3β

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Taldo

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Trx-2

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Trxr-1

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - Uch

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - awd

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - capt

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - chic

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - cib

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - dUTPase

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - dj-1β

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - eEF5

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - fabp

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - kdn

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - regucalcin

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - scf

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - scu

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - smt3

experimental knowledge based

(Guruharsha et al., 2011)

Fkbp14 - yip2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

Fkbp14

(van de Hoef et al., 2013)

Jra|kay

suppressible

Fkbp14

(Franciscovich et al., 2008)

kay

enhanceable

Fkbp14

(Franciscovich et al., 2008)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010470

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37449

MIST (protein-protein) - An integrated Molecular Interaction Database

Fkbp14

Pathways

Signaling Pathways (FlyBase)

Positive Regulators of Notch Signaling Pathway -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-95

Cytogenetic map

57E6-57E6

Sequence location

2R:21,487,167..21,497,929 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57E6-57E6

Limits computationally determined from genome sequence between P{PZ}tmx¹&P{EP}MESK2^EP2347 and P{PZ}Egfr⁰⁵³⁵¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

57E3-57E4

(determined by in situ hybridisation)

(Spradling et al., 1999)

57E3-57E4

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-95

(FlyBase, 2016)

2-101.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Bloomington

18553

w¹¹¹⁸; PBac{WH}Fkbp14^f02452

81532

w^*; P{ST.lexA::HG}Fkbp14^SE411

34181

y¹ w^*; Mi{MIC}Fkbp14^MI01360

53184

y¹ w^*; Mi{MIC}Fkbp14^MI09868

10962

cn¹ P{PZ}Fkbp14⁰⁰⁷³⁴/CyO; ry⁵⁰⁶

20145

y¹ w^67c23; P{EPgy2}Fkbp14^EY02405

37468

y¹ w^*; Mi{MIC}Fkbp14^MI04530/SM6a

66857

y¹ w^*; Mi{Trojan-GAL4.2}Fkbp14^{MI04530-TG4.2}

66358

y¹ w^*; Mi{PT-GFSTF.2}Fkbp14^{MI04530-GFSTF.2}/CyO

Kyoto

126127

w¹¹¹⁸; P{RS5}Fkbp14^5-SZ-3553

VDRC

v12863

w¹¹¹⁸; P{GD4819}v12863

v39071

w¹¹¹⁸; P{GD4819}v39071

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (73)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_GH08925

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010470

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010470

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37449

Antibody Information

Laboratory Generated Antibodies

polyclonal

(van de Hoef et al., 2013)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Fkbp14 Fkbp13

(van de Hoef et al., 2013)

Source for database merge of

Source for merge of: Fkbp13 BcDNA:GH08925 BcDNA:GM07659

(FlyBase, 1996-)

Additional comments

FlyBase curator comment: Originally named 'Fkbp13' (FBrf0111489) but here shown to be closer to mammalian FKBP14, so re-named accordingly.

(van de Hoef et al., 2013)

Source for merge of Fkbp13 BcDNA:GH08925 BcDNA:GM07659 was sequence comparison ( date:990717 ).

(FlyBase, 1996-)

Other Comments

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 71 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37449

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010470

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010470

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9847

Flygut - An atlas of the Drosophila adult midgut

FBgn0010470

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37449

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002441

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG9847

modMine - A data warehouse for the modENCODE project

FBgn0010470

Linkouts

DPiM - Drosophila Protein interaction map

FBgn0010470

DroID - A comprehensive database of gene and protein interactions.

FBgn0010470

DRSC - Results frm RNAi screens

FBgn0010470

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010470

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9847-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010470

FlyMine - An integrated database for Drosophila genomics

FBgn0010470

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37449

MIST (protein-protein) - An integrated Molecular Interaction Database

Fkbp14

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

BcDNA.GM07659

(de Morais Guedes et al., 2003, Tsang, 1999.3.2)

BcDNA:GH08925

BcDNA:GM07659

CG9847

(Ghartey-Kwansah et al., 2018, Misra et al., 2014, van de Hoef et al., 2013, Cammarato et al., 2011, Perkins et al., 2009, Haussmann et al., 2008, Grieder et al., 2007, Quinones-Coello, 2007, Molnar et al., 2006, Walker et al., 2006)

FKB13

(Johnson et al., 2004)

FKBP13

(Vinci et al., 2008, Bokel et al., 2006, Bokel et al., 2006)

FKBP14

(Ghartey-Kwansah et al., 2018, van de Hoef et al., 2013)

Fkbp14

(Jevitt et al., 2020, Kockel et al., 2019, Lee et al., 2018, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-)

GM07659

(Bryant et al., 1999)

fkbp13

(Vonhoff and Keshishian, 2017, Franciscovich et al., 2008)

l(2)00734

(Beaton, 2000.1.31, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

Name Synonyms

FK506-binding protein 14

FK506-binding protein 14 ortholog

Fkbp13

(Cammarato et al., 2011)

Secondary FlyBase IDs

FBgn0027068
FBgn0064945

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (87)

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