FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term peptidyl-prolyl cis-trans isomerase activity ID (Ontology) GO:0003755 (Gene Ontology)
Definition Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).[ EC:5 ]
Also Known As"cis-trans proline isomerase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 peptidyl-prolyl cis-trans isomerase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | peptidyl-prolyl cis-trans isomerase activity       --
 NOT | enables | peptidyl-prolyl cis-trans isomerase activity       --
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catalytic activity
 |__catalytic activity, acting on a protein__
isomerase activity                           |
 |__cis-trans isomerase activity_____________|
                                             peptidyl-prolyl cis-trans isomerase activity  38 rec.
                                              |__RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
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Is a cis-trans isomerase activity
catalytic activity, acting on a protein
Part of
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Synonyms
  • "cis-trans proline isomerase activity" EXACT
    "cyclophilin activity" RELATED[ EC:5 ]
    "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW
    "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW
    "immunophilin" RELATED
    "juglone-sensitive cis-trans proline isomerase activity" NARROW
    "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW
    "parvulin" RELATED
    "peptide bond isomerase activity" RELATED[ EC:5 ]
    "peptidyl-prolyl isomerase B reaction" RELATED
    "peptidylproline cis-trans-isomerase activity" RELATED[ EC:5 ]
    "peptidylprolyl cis-trans isomerase activity" RELATED[ EC:5 ]
    "peptidylprolyl isomerase activity" RELATED[ EC:5 ]
    "PPIase activity" RELATED[ EC:5 ]
    "rotamase activity" RELATED[ EC:5 ]
Secondary IDs
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EC:5.2.1.8
MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
Reactome:R-HSA-2022073 "Procollagen triple helix formation"
Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"
RHEA:16237