FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term peptidyl-prolyl cis-trans isomerase activity ID (Ontology) GO:0003755 (Gene Ontology)
Definition Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).[ EC:5 ]
Also Known As "cis-trans proline isomerase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      33
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 peptidyl-prolyl cis-trans isomerase activity (all annotations which use CV term, excluding "NOT" statements)       5     33
     enables | peptidyl-prolyl cis-trans isomerase activity       --      33
 NOT | enables | peptidyl-prolyl cis-trans isomerase activity       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
catalytic activity
 |__catalytic activity, acting on a protein__
isomerase activity                           |
 |__cis-trans isomerase activity_____________|
                                             peptidyl-prolyl cis-trans isomerase activity  38 rec.
                                              |__RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
                                                  |__RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a cis-trans isomerase activity
catalytic activity, acting on a protein
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "cis-trans proline isomerase activity" EXACT
    "cyclophilin activity" RELATED[ EC:5 ]
    "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW
    "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW
    "immunophilin" RELATED
    "juglone-sensitive cis-trans proline isomerase activity" NARROW
    "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW
    "parvulin" RELATED
    "peptide bond isomerase activity" RELATED[ EC:5 ]
    "peptidyl-prolyl isomerase B reaction" RELATED
    "peptidylproline cis-trans-isomerase activity" RELATED[ EC:5 ]
    "peptidylprolyl cis-trans isomerase activity" RELATED[ EC:5 ]
    "peptidylprolyl isomerase activity" RELATED[ EC:5 ]
    "PPIase activity" RELATED[ EC:5 ]
    "rotamase activity" RELATED[ EC:5 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:5.2.1.8
MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
Reactome:R-HSA-2022073 "Procollagen triple helix formation"
Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"
RHEA:16237