Gene Group: FK506-BINDING PROTEINS

General Information

Name

FK506-BINDING PROTEINS

Species

D. melanogaster

Symbol

FKBP

FlyBase ID

FBgg0000947

Date last reviewed

2019-11-08

Number of members

Description

FK506-binding proteins are a class of evolutionary conserved peptidyl prolyl cis/trans isomerases. In vertebrates, they form binary complexes with their ligand, FK506 or rapamycin, and are involved in key biochemical processes including protein folding, receptor signalling, protein trafficking, and transcription. FK506-binding proteins are characterized by the presence of a 'FKBP-type peptidyl-prolyl cis-trans isomerase domain' (IPR001179). (Adapted from PMID:25986569.)

Notes on Group

Bdbt (FBgn0038857) has the InterPro family signature "Peptidyl-prolyl cis-trans isomerase, FKBP-type (IPR023566)" but lacks the InterPro domain "FKBP-type peptidyl-prolyl cis-trans isomerase domain (IPR001179)". Further, Bdbt is not included in the list of FKBP family protein in FBrf0238473, and so is excluded from the FKBP Gene Group.

Source Material

The FK506-BINDING PROTEINS Gene Group has been compiled using the following publication(s): Kang et al., 2025 and Ghartey-Kwansah et al., 2018 .

Key Gene Ontology (GO) terms

Molecular Function

peptidyl-prolyl cis-trans isomerase activity

Biological Process

protein peptidyl-prolyl isomerization

Cellular Component

Enzymatic activity

Enzyme name (EC)

peptidylprolyl isomerase (5.2.1.8)

Related Gene Groups