FlyBase Allele Report: Dmel\Fkbp14[D58]

General Information

Symbol

Dmel\Fkbp14^D58

Species

D. melanogaster

Name

FlyBase ID

FBal0284421

Feature type

allele

Associated gene

Dmel\Fkbp14

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(van de Hoef et al., 2013)

Mutagen

Progenitor genotype

P{EP}Fkbp14^EP2019

(van de Hoef et al., 2013)

Cytology

Description

Imprecise excision of P{EP}Fkbp14^EP2019, resulting in a 2405bp deletion that includes residues 105-145 of Fkbp14 exon 1 and the entire exon 2 (including the translation start site).

(van de Hoef et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:21,494,700..21,497,104 [-]

Comment:

2405 bp deletion resulting from the imprecise excsion of P{EP}Fkbp14^EP2019 that removes the last 41 bases of exon 1 of Fkbp14-RA and Fkbp14-RD and sequences downstream including the first coding exon.

(van de Hoef et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

cell lethal | larval stage | somatic clone

(van de Hoef et al., 2013)

female sterile | germline clone

(van de Hoef et al., 2013)

lethal (with Fkbp14^EP2019)

(van de Hoef et al., 2013)

lethal (with Fkbp14^EP2206)

(van de Hoef et al., 2013)

lethal - all die before end of P-stage

(van de Hoef et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous escapers reach late pupal development as pharate adults.

Fkbp14^D58 pharates show mild wing margin notching, loss of wing margin bristles, and wing margin bristle doublets.

Fkbp14^D58 third instar wing discs show a loss of SOPs in the presumptive wing margin, pouch and hinge regions.

Fkbp14^D58 pharate nota show significantly reduced numbers of microchaetae and macrochaetae.

Fkbp14^D58 third instar wing discs show a loss of SOPs in the presumptive notum.

The predominant Fkbp14^D58 phenotype is a loss of imaginal discs, with 80% of homozygotes lacking them.

Females with Fkbp14^D58 germline clones are sterile and do not lay eggs.

Fkbp14^D58 somatic clones in imaginal discs are not observed, indicating a requirement of Fkbp14^D58 for cell viability.

(van de Hoef et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Fkbp14^D58/Fkbp14[+] is an enhancer of wing vein L2 phenotype of Delta⁷

(van de Hoef et al., 2013)

Fkbp14^D58/Fkbp14[+] is an enhancer of wing vein | ectopic phenotype of Delta⁷

(van de Hoef et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Fkbp14^D58/+ enhances the L2 vein thickening and ectopic deltas seen in Dl⁷/+ wings.

Fkbp14^D58/+ enhances the distal wing margin notching seen in Df(1)N-8/+ wings.

(van de Hoef et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

FKBP14^D58

(van de Hoef et al., 2013)

Fkbp14^D58

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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