Adf-1, nal, nalyot, l(2)01349, Adf 1
Gene model reviewed during 5.48
Gene model reviewed during 5.44
Stop-codon suppression (UAA) postulated; FBrf0216884
Low-frequency RNA-Seq exon junction(s) not annotated.
1.9 (northern blot)
253 (aa); 29 (kD)
O-glycosylated; contains N-acetylglucosamine side chains.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Adf1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Adf1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Adf1 results in increased arborization of ddaD and ddaE neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
Adf1 may be a critical regulatory switch involved in terminal stages of synapse maturation.
Comprehensive mapping of the functional domains of Adf1 to study the role of transactivators in the process of gene activation.
The specific setting of a nucleosome and the particular histone-DNA contacts over the factor binding sites may play important roles in modulating Adf1 and Trl protein binding to the Adh distal promoter in chromatin to regulate transcription.