FB2026_02 , released June 18, 2026
Allele: Dmel\Adf1nal
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General Information
Symbol
Dmel\Adf1nal
Species
D. melanogaster
Name
FlyBase ID
FBal0047988
Feature type
allele
Associated gene
Dmel\Adf1
Associated Insertion(s)
P{lacW}Adf1nal
Carried in Construct
Also Known As
nalP1
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(DeZazzo et al., 2000)
Mutagen
P-element activity
(Tully, 1995)
Progenitor genotype
Associated Insertion(s)
P{lacW}Adf1nal
Cytology
Description

The P{lacW} insertion is positioned within the large intron of the Adf1 transcription unit, 147 bp downstream of the splice donor site.

(DeZazzo et al., 2000)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RP2 neurons in heterozygotes show a 50% reduction in both the number of dendritic branches and the total dendrite length compared to controls.

      (Timmerman et al., 2013)

      After Pavlovian olfactory conditioning, Adf1nal show a slight but significant disruption of conditioned odour avoidance behaviour. Mutants display normal "task relevant" sensorimotor responses. Mutants also show wild-type shock reactivity at the and olfactory acuity to MCH and OCT. Adf1nal/Adf1le60 and Adf1nal homozygotes routinely survive to adulthood. Visual inspection of frontal sections of adult brains reveal nor obvious malformations in gross anatomy. Mutants have less synaptic boutons than wild-type. Miniature excitatory junctional current (mEJC) amplitude and frequency are normal in homozygous mutants.

      (DeZazzo et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Adf1nal is rescued by Adf1hs.PD

      (DeZazzo et al., 2000)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The memory phenotype is revertable by excision of the P{lacW} insertion. Etymology: the mutant "nalyot" is named after one of Pavlov's dogs and means "fast appearance of gangsters" in Russian.

      (DeZazzo et al., 2000)

      Etymology: 'nal' recalls Nalyot, one of Pavlov's dogs.

      (DeZazzo et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Adf1nal
      nal
      (Tully, 1995)
      nalP1
      (Timmerman et al., 2013, DeZazzo et al., 2000)
      Name Synonyms
      nalyot
      (Timmerman et al., 2013)
      Secondary FlyBase IDs
        References (7)