FB2026_02 , released June 18, 2026
Allele: Dmel\Adf1hs.PD
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General Information
Symbol
Dmel\Adf1hs.PD
Species
D. melanogaster
Name
heat shock construct of DeZazzo
FlyBase ID
FBal0119716
Feature type
allele
Associated gene
Dmel\Adf1
Associated Insertion(s)
Carried in Construct
P{hs-Adf1.D}
Key Links
Transgenic product class
cDNA
(DeZazzo et al., 2000)
wild_type
(DeZazzo et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(DeZazzo et al., 2000)
wild_type
(DeZazzo et al., 2000)
Mutagen
in vitro construct
(DeZazzo et al., 2000)
Progenitor genotype
Carried in construct
P{hs-Adf1.D}
Cytology
Description

A 1603bp Adf1 cDNA fragment is inserted driven by a Hsp70 promoter. This fragment spans the region from 133bp upstream of the start codon to 709 bp downstream of the stop codon.

(DeZazzo et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Adf1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When raised at 25oC olfactory memory is lower than normal. However 309 minute heatshock treatments do not appear to have any effect on olfactory memory. Miniature excitatory junctional current (mEJC) amplitude is normal in mutants, though an increase in mEJC frequency is occasionally seen. Adf1hs.PD mutants grown at 21oC have more synaptic boutons than seen in wild-type.

      (DeZazzo et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Adf1hs.PD rescues Adf1nal

      (DeZazzo et al., 2000)
      Comments

      Leaky expression of Adf1hs.PD can rescue the lethality of Adf1nal at 18oC or 25oC. When flies raised at 18oC are shifted to 25oC for the first three days after eclosion, the memory defect is also rescued.

      (DeZazzo et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Adf1hs.PD
      Name Synonyms
      heat shock construct of DeZazzo
      (DeZazzo et al., 2000)
      Secondary FlyBase IDs
        References (1)