FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Adf1le60
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General Information
Symbol
Dmel\Adf1le60
Species
D. melanogaster
Name
FlyBase ID
FBal0119714
Feature type
allele
Associated gene
Dmel\Adf1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(DeZazzo et al., 2000)
Progenitor genotype
Adf1nal
(DeZazzo et al., 2000)
Cytology
Description

The Adf1le60 excision consists of 30bp of residual P-element sequences, an 8bp target site duplication and an approximately 1800bp deletion of nearby genomic DNA. The lesion extends from 351bp upstream of the terminal exon to 150bp past the poly(A) site.

(DeZazzo et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adf1nal/Adf1le60 animals routinely survive to adulthood. About 75% of homozygotes die as mature embryos. The remaining 25% hatch and manifest behavioural responses, such as forward and backward locomotion to tactile stimuli. These animals are sluggish, fail to grow normally, and die before the third instar larval stage. In late stage homozygotes, development of the central nervous system the peripheral nervous system, and trachea appears normal. In tests for 1 day and seven day memory retention, the former is found to be normal in these mutants, but the long term seven day memory is found to be abolished.

      (DeZazzo et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Adf1le60
      nalle60
      (DeZazzo et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)