FlyBase Gene Report: Dmel\Fur2

General Information

Symbol

Dmel\Fur2

Species

D. melanogaster

Name

Furin 2

Annotation Symbol

CG18734

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004598

Gene Model Status

Current

Stock Availability

14 publicly available

Enzyme Name (EC)

Gene Summary

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. (UniProt, P30432)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dfur2, Dfurin2, furin

Key Links

Genomic Location

Cytogenetic map

14C1-14C2

Sequence location

X:16,373,086..16,381,782 [+]

Recombination map

1-53

RefSeq locus

NC_004354 REGION:16373086..16381782

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from genetic interaction with FLYBASE:Fur1; FB:FBgn0004509

(Künnapuu et al., 2009)

inferred from direct assay

(Roebroek et al., 1992)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN002451026

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR002884, InterPro:IPR036852

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR036852

(InterPro Project Members, 2004-)

enables serine-type peptidase activity

inferred from electronic annotation with InterPro:IPR000209

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of secretion

inferred from genetic interaction with FLYBASE:Pgant4; FB:FBgn0051956

(Zhang et al., 2014)

involved_in R8 cell fate specification

inferred from mutant phenotype

(Wells et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein processing

inferred from biological aspect of ancestor with PANTHER:PTN002451026

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR002884, InterPro:IPR036852

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000209, InterPro:IPR036852

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in Golgi membrane

inferred from biological aspect of ancestor with PANTHER:PTN000082856

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with FLYBASE:Fur1; FB:FBgn0004509

(Roebroek et al., 1992)

is_active_in trans-Golgi network

inferred from biological aspect of ancestor with PANTHER:PTN000082856

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PROPROTEIN CONVERTASES

Protein Family (UniProt)

Belongs to the peptidase S8 family. Furin subfamily. (P30432)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

serine-type endopeptidase activity

Summaries

Gene Group (FlyBase)

PROPROTEIN CONVERTASES -: Proprotein convertases are serine endopeptidases related to bacterial subtilisin-like enzymes. They activate a broad range of secretory proteins via post-translational cleavage of inactive precursor molecules. The targets and substrates of these convertases are very varied covering many aspects of cellular biology and communication. (Adapted from PMID:22204726.)

Protein Function (UniProtKB)

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

(UniProt, P30432)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Fur2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P30432)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Fur2-RA

FBtr0074261

NM_167506

5559

1682

Fur2-RB

FBtr0074265

NM_167507

5659

1682

Fur2-RC

FBtr0074263

NM_167508

5593

1682

Fur2-RD

FBtr0074262

NM_078644

5550

1679

Fur2-RE

FBtr0074266

NM_167509

5653

1679

Fur2-RF

FBtr0074264

NM_167510

5770

1679

Fur2-RG

FBtr0074267

NM_206763

5774

1679

Fur2-RH

FBtr0301300

NM_001169302

5601

586

Fur2-RI

FBtr0301301

NM_001169303

5478

1655

Additional Transcript Data and Comments

Reported size (kB)

6.0 (unknown)

(Roebroek et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Fur2-PA

FBpp0074038

183.7

1682

6.54

NP_727963

AAF48598

Fur2-PB

FBpp0074042

183.7

1682

6.54

NP_727964

AAF48599

Fur2-PC

FBpp0074040

183.7

1682

6.54

NP_727965

AAN09399

Fur2-PD

FBpp0074039

183.4

1679

6.52

FBpp0074043

183.4

1679

6.52

FBpp0074041

183.4

1679

6.52

FBpp0089399

183.4

1679

6.52

FBpp0290515

64.2

586

7.14

FBpp0290516

180.7

1655

6.55

E1JJL4

NP_001162774

ACZ95309

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1682 aa isoforms: Fur2-PA, Fur2-PB, Fur2-PC

1679 aa isoforms: Fur2-PD, Fur2-PE, Fur2-PF, Fur2-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

1680 (aa)

(Roebroek et al., 1992)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S08.071

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fur2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

Additional Descriptive Data

Fur2 transcripts are expressed throughout development with the highest levels in adults.

(Roebroek et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fur2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fur2

View exonic expression by tissue for Dmel\Fur2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32604/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004598

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004598

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004598

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18734

Flygut - An atlas of the Drosophila adult midgut

FBgn0004598

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fur2

Transgenic constructs containing regulatory region of Fur2

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 16 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fur2^GD118

viable, with Scer\GAL4^Mef2.PR

Fur2^GD118

viable, with Scer\GAL4^pnr-MD237

Fur2^GD118

viable, with Scer\GAL4^tin.CΔ4

Fur2^GD118

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\PCSK5

11 of 14

Yes

Hsap\PCSK6

9 of 14

Yes

7 of 14

6 of 14

5 of 14

5 of 14

Yes

Hsap\PCSK2

4 of 14

Hsap\FRAS1

3 of 14

Yes

Hsap\PCSK9

3 of 14

Yes

Hsap\MBTPS1

2 of 14

Hsap\RSPO1

2 of 14

Yes

Hsap\RSPO2

2 of 14

Yes

Hsap\RSPO3

2 of 14

Yes

Hsap\RSPO4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Pcsk5

11 of 14

Yes

Rnor\Pcsk6

9 of 14

Yes

Rnor\Pcsk4

7 of 14

Rnor\Furin

6 of 14

Rnor\Pcsk1

5 of 14

Yes

Rnor\Pcsk7

5 of 14

Yes

Rnor\Pcsk2

4 of 14

Rnor\Fras1

3 of 14

Yes

Rnor\Pcsk9

3 of 14

Yes

Rnor\Rspo1

2 of 14

Yes

Rnor\Rspo2

2 of 14

Yes

Rnor\Rspo3

2 of 14

Yes

Rnor\Rspo4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Pcsk5

11 of 14

Yes

Mmus\Pcsk6

9 of 14

Yes

Mmus\Pcsk4

7 of 14

Mmus\Furin

6 of 14

Mmus\Pcsk1

5 of 14

Yes

Mmus\Pcsk7

5 of 14

Yes

Mmus\Fras1

3 of 14

Yes

Mmus\Pcsk2

3 of 14

Mmus\Pcsk9

3 of 14

Yes

Mmus\Mbtps1

2 of 14

Mmus\Rspo1

2 of 14

Yes

Mmus\Rspo2

2 of 14

Yes

Mmus\Rspo3

2 of 14

Yes

Mmus\Rspo4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Tpp2

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\pcsk5

7 of 13

Yes

Xtro\pcsk6

4 of 13

Xtro\tspan31

4 of 13

Xtro\pcsk1

3 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

Yes

Xtro\vip

2 of 13

Yes

Xtro\col12a1

1 of 13

Yes

Xtro\fras1

1 of 13

Xtro\htr6

1 of 13

Yes

Xtro\igf1r

1 of 13

Xtro\LOC100486641

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\rspo2

1 of 13

Yes

Xtro\tapt1

1 of 13

Xtro\vsig1

1 of 13

Yes

Danio rerio (Zebrafish) (23)

Drer\pcsk5a

11 of 14

Yes

Drer\pcsk5b

8 of 14

Yes

6 of 14

6 of 14

5 of 14

5 of 14

Yes

Drer\pcsk7

5 of 14

Yes

Drer\fras1

3 of 14

Yes

Drer\pcsk2

3 of 14

Drer\pcsk9

3 of 14

Yes

Drer\mbtps1

2 of 14

Drer\rspo2

2 of 14

Yes

Drer\rspo3

2 of 14

Yes

Drer\rspo4

2 of 14

Yes

Drer\hmcn2

1 of 14

Drer\igf1rb

1 of 14

Drer\LOC100330575

1 of 14

Yes

Drer\rspo1

1 of 14

Yes

Drer\si:dkey-178e17.3

1 of 14

Drer\spon1b

1 of 14

Drer\spon2b

1 of 14

Drer\thsd7bb

1 of 14

Yes

Drer\tpp2

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\bli-4

9 of 14

Yes

6 of 14

3 of 14

3 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP002915

12 of 12

Yes

4 of 12

3 of 12

2 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (59)

Atha\AT3G14240

2 of 13

Yes

Atha\S1P

2 of 13

Yes

Atha\AIR3

1 of 13

Atha\ARA12

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G05920

1 of 13

Yes

Atha\AT2G39850

1 of 13

Atha\AT3G14067

1 of 13

Yes

Atha\AT3G25850

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\ATSBT5.2

1 of 13

Atha\SBT1.3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\SDD1

1 of 13

Yes

Atha\SLP2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\KEX2

8 of 13

Yes

Scer\PRB1

2 of 13

Scer\RRT12

2 of 13

Scer\YSP3

2 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\krp1

7 of 12

Yes

Spom\isp6

2 of 12

Spom\psp3

2 of 12

Spom\tpp2

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Fur2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

amon

8 of 13

Fur1

8 of 13

S1P

3 of 13

TppII

2 of 13

vex

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

FRAS1; Fraser extracellular matrix complex subunit 1

model of Fraser syndrome 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PCSK5; proprotein convertase subtilisin/kexin type 5

11 of 14

600488

PCSK6; proprotein convertase subtilisin/kexin type 6

9 of 14

167405

PCSK4; proprotein convertase subtilisin/kexin type 4

7 of 14

600487

FURIN; furin, paired basic amino acid cleaving enzyme

6 of 14

136950

PCSK1; proprotein convertase subtilisin/kexin type 1

5 of 14

162150

proprotein convertase 1/3 deficiency

PCSK7; proprotein convertase subtilisin/kexin type 7

5 of 14

604872

PCSK2; proprotein convertase subtilisin/kexin type 2

4 of 14

162151

FRAS1; Fraser extracellular matrix complex subunit 1

3 of 14

607830

FRASER SYNDROME 1; FRASRS1

Fraser syndrome 1

PCSK9; proprotein convertase subtilisin/kexin type 9

3 of 14

607786

HYPERCHOLESTEROLEMIA, FAMILIAL, 3; FHCL3

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pgant4

suppressible

Fur2

(Zhang et al., 2014)

trk

enhanceable

Fur2

(Johnson et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58944

DroID - A comprehensive database of gene and protein interactions.

FBgn0004598

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Viral life cycle - HIV-1

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P30432

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-53

Cytogenetic map

14C1-14C2

Sequence location

X:16,373,086..16,381,782 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14C1-14C2

Limits computationally determined from genome sequence between P{EP}Cyp1^EP1073&P{EP}Dsp1^EP355 and P{EP}EP1493^EP1493

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

14C-14C

(determined by in situ hybridisation)

(Roebroek et al., 1992)

Experimentally Determined Recombination Data

Location

1-53

(FlyBase, 2016)

1-54.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

25959

y¹ v¹; P{TRiP.JF01979}attP2

42577

y¹ v¹; P{TRiP.HMJ02236}attP40

63081

w^*; P{UAS-Fur2.R}21a/TM3, Sb¹

98512

w^* TI{CRIMIC.TG4.0}Fur2^{CR70756-TG4.0}

11429

w¹¹¹⁸ P{EP}EP1493^EP1493 Fur2^EP1493

63080

y¹ w^* Fur2^R4 P{FRT(w^hs)}9-2/FM7h

Kyoto

104593

y^* w^* P{GawB}Fur2^NP4074 / FM7c

NIG-Fly

18734R-1

P{NIG.18734R}1

18734R-3

P{NIG.18734R}3

HMJ02236

y¹ v¹; P{TRiP.HMJ02236}attP40/CyO

VDRC

v101242

P{KK104000}VIE-260B

v1021

w¹¹¹⁸; P{GD118}v1021

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (93)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004598

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004598

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The genetic organisation, expression during embryogenesis and cleavage specificity of Fur2 gene product have been characterised.

(Roebroek et al., 1995)

Fur2 encodes an endoproteolytic enzyme. Cos cell transfection experiments with von Willebrand factor reveal a specificity for action on paired basic amino acid residues.

(Roebroek et al., 1992)

Isolated from a genomic library using a human furin cDNA as a probe, under reduced stringency conditions.

(Roebroek et al., 1991)

Fur2 has been cloned.

(Roebroek et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: Fur2 CG18734

(FlyBase, 1996-)

Additional comments

Source for merge of Fur2 CG18734 was sequence comparison ( date:001104 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

154521_at

(Kristensen et al., 2005)

CG18734

(Haelterman et al., 2014, Ni et al., 2010.12.1, Gelbart et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Larschan et al., 2007, Larschan et al., 2007)

CG4235

DMH#11

(Siekhaus and Fuller, 1999)

Dfur2

(Zhang et al., 2014, Künnapuu et al., 2009, Siekhaus and Fuller, 1999, de Bie et al., 1995, Roebroek et al., 1995, Roebroek, 1994, Roebroek et al., 1993, Roebroek et al., 1992, Roebroek et al., 1991)

Dfurin2

(Bruning et al., 2007)

FUR2

(Roebroek, 1992.9.17)

Furin

(Lopez-Schier, 2003)

fur2

(Sohr et al., 2019, Inlow and Restifo, 2004, Siezen and Leunissen, 1997)

furin

(Artavanis-Tsakonas et al., 1999, Sappington and Raikhel, 1998)

Name Synonyms

Dfurin2

(Künnapuu et al., 2009, Roebroek et al., 1991)

Furin 2

(Roebroek et al., 1992)

Furin-like protease

(Allman et al., 2002)

Furin2

(Salazar and Yamamoto, 2018)

furin 2

(Mudiganti et al., 2010)

furin2

(Lake et al., 2009)

Secondary FlyBase IDs

FBgn0042227

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External Crossreferences and Linkouts ( 81 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32604

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P30432

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P30432

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P30432

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32604/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004598

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004598

FlyMine - An integrated database for Drosophila genomics

FBgn0004598

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18734

MARRVEL_MODEL - MARRVEL (model organism gene)

32604

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

S08.071

Linkouts

BioGRID - A database of protein and genetic interactions.

58944

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004598

DroID - A comprehensive database of gene and protein interactions.

FBgn0004598

DRSC - Results frm RNAi screens

FBgn0004598

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004598

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004598

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18734

Flygut - An atlas of the Drosophila adult midgut

FBgn0004598

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031960

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Viral life cycle - HIV-1

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P30432

References (91)

The following external sites may use different assemblies or annotations than FlyBase.

-0.79

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