FlyBase Allele Report: Dmel\Fur1[GL01340]

General Information

Symbol

Dmel\Fur1^GL01340

Species

D. melanogaster

Name

FlyBase ID

FBal0281163

Feature type

allele

Associated gene

Dmel\Fur1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL01340}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.GL01340}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL01340

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of schizophrenia

CEA

(Foka et al., 2022)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^G14

(Kim et al., 2015)

abnormal size | larval stage, with Scer\GAL4^bnl.PU

(Sohr et al., 2019)

some die during larval stage, with Dcr-2^UAS.cDa, Scer\GAL4^G14

(Kim et al., 2015)

some die during larval stage | heat sensitive, with Scer\GAL4^G14

(Kim et al., 2015)

Phenotype Manifest In

air sac primordium | larval stage, with Scer\GAL4^bnl.PU

(Sohr et al., 2019)

terminal bouton, with Scer\GAL4^G14

(Kim et al., 2015)

Detailed Description

Statement

Reference

Expressing Fur1^GL01340 under the control of Scer\GAL4^bnl.PU occasionally leads to stunted air sac primordium development, compared to controls.

(Sohr et al., 2019)

Expression of Fur1^GL01340 driven by Scer\GAL4^{nos.UTR.T:Hsim\VP16} produces mostly wild type larvae.

(Johnson et al., 2015)

Expression of Fur1^GL01340 under the control of Scer\GAL4^G14 results in a reduction in NMJ bouton number. At high expression levels (at high temperatures or in the presence of Dcr-2^Scer\UAS.cDa) the muscles are distorted and early larval lethality is seen.

(Kim et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Fur1^GL01340, Scer\GAL4^{VP16.nanos.UTR} is an enhancer of embryonic/larval segmentation phenotype phenotype of Scer\GAL4^{VP16.nanos.UTR}, trk^{N.UASp.Tag:MYC,mCherry}

(Johnson et al., 2015)

Other

Statement

Reference

Fur1^GL01340, Fur2^GLC01802, Scer\GAL4^{VP16.nanos.UTR} has abnormal dorsal/ventral axis specification | larval stage phenotype

(Johnson et al., 2015)

Fur1^GL01340, Fur2^GLC01802, Scer\GAL4^{VP16.nanos.UTR} has embryonic/larval segmentation phenotype | larval stage phenotype

(Johnson et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Fur1^GL01340, Scer\GAL4^{VP16.nanos.UTR} is an enhancer of filzkorper phenotype of Scer\GAL4^{VP16.nanos.UTR}, trk^{N.UASp.Tag:MYC,mCherry}

(Johnson et al., 2015)

Other

Statement

Reference

Fur1^GL01340, Fur2^GLC01802, Scer\GAL4^{VP16.nanos.UTR} has filzkorper phenotype

(Johnson et al., 2015)

Fur1^GL01340, Fur2^GLC01802, Scer\GAL4^{VP16.nanos.UTR} has cephalopharyngeal skeleton phenotype

(Johnson et al., 2015)

Fur1^GL01340, Fur2^GLC01802, Scer\GAL4^{VP16.nanos.UTR} has germ band phenotype

(Johnson et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Knockdown of Fur1^GL01340 or Fur2^GLC01802 alone (driven by Scer\GAL4^{nos.UTR.T:Hsim\VP16}) produces mostly wild type larvae, but knockdown of both together results in a loss of terminal structures (reduction in posterior filzkorper, head skeleton defects) and phenotypes consistent with dorso-ventral patterning defects (lateral denticle belt fields, head involution, germ band retraction failure).

Co-expression of Fur1^GL01340 significantly enhances terminal patterning defects in Scer\GAL4^{nos.UTR.T:Hsim\VP16}>trk^{N.Scer\UAS.P\T.T:Hsap\MYC,T:Disc\RFP-mCherry} larvae.

(Johnson et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42481

y¹ sc^* v¹ sev²¹; P{TRiP.GL01340}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Fur1^GL01340

Fur1^shRNA

(Johnson et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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