FlyBase Allele Report: Dmel\Lrrk[Q1003H.UAS]

General Information

Symbol

Dmel\Lrrk^Q1003H.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0368465

Feature type

allele

Associated gene

Dmel\Lrrk

Associated Insertion(s)

Carried in Construct

P{UAS-Lrrk.Q1003H}

Key Links

Transgenic product class

missense_variant

(Sarkar et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Sarkar et al., 2021)

Mutagen

in vitro construct

(Sarkar et al., 2021)

Progenitor genotype

Carried in construct

P{UAS-Lrrk.Q1003H}

Cytology

Description

UAS regulates expression of Lrrk containing a Q1003H substitution, a GTPase domain mutant designed to mimic the 'protective' Hsap\LRRK2-R1398H mutant.

(Sarkar et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Lrrk

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^QUAS.cOa

(Sarkar et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP is a suppressor of decreased cell number | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP is a suppressor of dopaminergic medulla neuron | adult stage | decreased number phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP is a suppressor of outer medulla | adult stage phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Lrrk^Q1003H.UAS/Scer\GAL4^nSyb.PP is a suppressor of medulla intrinsic columnar neuron | adult stage | decreased number phenotype of Hsap\SNCA^QUAS.cOa, Ncra\QF^QF2.nSyb

(Sarkar et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Lrrk^Q1003H.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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