FlyBase Allele Report: Dmel\Dcr-1[RNAi.UAS.cUa]

General Information

Symbol

Dmel\Dcr-1^RNAi.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0407433

Feature type

allele

Associated gene

Dmel\Dcr-1

Associated Insertion(s)

Carried in Construct

P{UAS-Dcr-1.RNAi.U}

Key Links

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Dcr-1.RNAi.U}

Cytology

Description

UAS regulatory sequences drive expression of an RNAi construct targeting Dcr-1.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dcr-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by Lrrk^I1915T.UAS

(Gehrke et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Dcr-1^VDRC.cUa driven by Scer\GAL4^ple.PF in a heterozygous Dcr-1^Q1147X genetic background results in dopaminergic neuron loss and climbing defects.

(Gehrke et al., 2010)

Adults expressing Dcr-1^VDRC.cUa under the control of Scer\GAL4^tim.PE have normal locomotor activity rhythms.

(Kadener et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Dcr-1^RNAi.UAS.cUa, Scer\GAL4^ple.PF is an enhancer of abnormal neuroanatomy phenotype of Lrrk^I1915T.UAS, Scer\GAL4^ple.PF

(Gehrke et al., 2010)

Other

Statement

Reference

Dcr-1^RNAi.UAS.cUa, Scer\GAL4^tim.PE, cyc^VP16.UAS has abnormal locomotor rhythm phenotype

(Kadener et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

Dcr-1^RNAi.UAS.cUa, Scer\GAL4^ple.PF is an enhancer of dopaminergic neuron phenotype of Lrrk^I1915T.UAS, Scer\GAL4^ple.PF

(Gehrke et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

In flies expressing Lrrk^{I1915T.Scer\UAS} driven by Scer\GAL4^ple.PF, Dcr-1^VDRC.cUa-overexpression exacerbates the neuronal toxicity of Lrrk^{I1915T.Scer\UAS}.

(Gehrke et al., 2010)

Co-expression of cyc^{Scer\UAS.T:Hsim\VP16} and Dcr-1^VDRC.cUa under the control of Scer\GAL4^tim.PE at 29[o]C results in adults in which the amplitude of the locomotor activity rhythms is dramatically reduced compared to controls.

(Kadener et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dcr-1^RNAi.UAS.cUa

Dcr-1^VDRC.cUa

Dcr-1^{dsRNA.Scer\UAS.cUa}

Dcr-1^{dsRNA.UAS.cUa}

Name Synonyms

Secondary FlyBase IDs

FBal0268275
FBal0246463

References (5)

Report Sections

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