Lrrk^ex1 adult flies display shorter lifespan, reduced and rapidly deteriorating climbing ability, decreased evoked postsynaptic potential (ePSP) latency and unlike wild-type do not show the sharp reduction in the ePSP amplitude after the second PSP in response to a train of stimuli with 200 Hz stimulation (recorded from dorsal longitudinal muscle fibers upon stimulation of the giant fiber system). The flies also display ultrastructural mitochondrial defects (damaged and swollen mitochondria with fragmented cristae) in the thoracic ganglia.

Lrrk^ex1 mutant adults show defects in Electroantennogram measurements in response to to olfactory stimulation with 1-Hexanol or 1-Linallol, as compared to controls.

Lrrk^ex1 mutant adults show lower attraction to 1-Hexanol and 1-Linallol in free walking bioassays (trap entry assay), as compared to controls.

Although Lrrk^ex1 homozygote adults present no gross alteration of the antennal olfactory apparatus, there are higher numbers of trichoid, small basiconic and grooved sensilla, as compared to controls.

Lrrk^e03680/Lrrk^ex1 mutant larval neuromuscular junctions do not exhibit any significant difference in amplitude of miniature excitatory junction currents (mEJCs), EJCs, or quantal content, as compared to controls, but they do exhibit an increase in the total number of synaptic boutons.

Lrrk^ex1 mutant flies do not show any elevation in response across a range of spatiotemporal frequencies of contrast-reversing sine-wave gratings as compared to responses from control flies.

Lrrk^ex1 mutant animals show severely impaired locomotor activity.