FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Lrrk2
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General Information
Symbol
Dmel\Lrrk2
Species
D. melanogaster
Name
FlyBase ID
FBal0319308
Feature type
allele
Associated gene
Dmel\Lrrk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Dodson et al., 2014)
Progenitor genotype
Cytology
Description

Single nucleotide insertion that changes codon L584 to F and results in a frameshift that generates a stop codon 11 codons downstream.

(Dodson et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
insertion
3R:20,638,121..20,638,122 [+]
Comment:

Inferred site of 1 base insertion that changes codon L584 to F and results in a frameshift that generates a stop codon 11 codons downstream (changed base is L584F folowed by AGSSCAANANX).

Inserted_sequence:

Y

(Dodson et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lrrk1/Lrrk2 mutants show significantly reduced female fertility.

      Lrrk2/Lrrk3 mutants show significantly reduced female fertility.

      (Dodson et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Lrrk2/Lrrk1 has semi-sterile phenotype, suppressible by Scer\GAL4CY2/Hsap\LRRK2UAS.Tag:HA

      (Dodson et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\LRRK2Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4CY2 rescues the semi-sterility phenotype of Lrrk1/Lrrk2 mutants.

      (Dodson et al., 2014)
      Complementation and Rescue Data
      Rescued by

      Lrrk2/Lrrk1 is rescued by Scer\GAL4CY2/LrrkUAS.cDa

      (Dodson et al., 2014)

      Lrrk2/Lrrk1 is rescued by Scer\GAL4CY2/LrrkG1914S.UAS

      (Dodson et al., 2014)
      Comments

      Expression of LrrkG1914S.Scer\UAS under the control of Scer\GAL4CY2 rescues the semi-sterility phenotype of Lrrk1/Lrrk2 mutants.

      Expression of LrrkScer\UAS.cDa under the control of Scer\GAL4CY2 rescues the semi-sterility phenotype of Lrrk1/Lrrk2 mutants.

      (Dodson et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Lrrk2
      lrrk2
      (Dodson et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)