FlyBase Allele Report: Dmel\Lrrk[1]

General Information

Symbol

Dmel\Lrrk¹

Species

D. melanogaster

Name

FlyBase ID

FBal0319307

Feature type

allele

Associated gene

Dmel\Lrrk

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Dodson et al., 2014)

Progenitor genotype

Cytology

Description

Amino acid replacement: L389term.

(Dodson et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:20,637,480..20,637,480 [+]

Nucleotide change:

T20637480A

Amino acid change:

L389term | Lrrk-PB; L366term | Lrrk-PC; L457term | Lrrk-PD

Reported amino acid change:

L389term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Dodson et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease 8

CEC

(Inoshita et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Parkinson's disease 8

is exacerbated by Rab3^{T35N.UASp.YFP}

(Inoshita et al., 2022)

is exacerbated by Rab3-GEF^HM05165

(Inoshita et al., 2022)

is ameliorated by Rab3-GEF^UAS.cBa

(Inoshita et al., 2022)

is exacerbated by Rab32^UASp.YFP

(Inoshita et al., 2022)

is ameliorated by Rme-8^fl.UAS.mRFP1

(Inoshita et al., 2022)

is exacerbated by Vps35^MH20

(Inoshita et al., 2022)

is ameliorated by Vps35^UAS.cIa

(Inoshita et al., 2022)

is ameliorated by g^{αTub84B.mCherry}

(Inoshita et al., 2022)

is ameliorated by Aplip1^KK107996

(Inoshita et al., 2022)

is ameliorated by g¹

(Inoshita et al., 2022)

is exacerbated by sp3^LL05626

(Inoshita et al., 2022)

is ameliorated by sp3^UAS.cIa

(Inoshita et al., 2022)

is ameliorated by unc-104^P350

(Inoshita et al., 2022)

is exacerbated by unc-104^{UAS.RVB.GFP(S65T)}

(Inoshita et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

semi-sterile (with Lrrk²)

(Dodson et al., 2014)

semi-sterile (with Lrrk³)

(Dodson et al., 2014)

semi-sterile (with Lrrk⁴)

(Dodson et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Lrrk¹/Lrrk² mutants show significantly reduced female fertility.

Lrrk¹/Lrrk³ mutants show significantly reduced female fertility.

Lrrk¹/Lrrk⁴ mutants show significantly reduced female fertility.

(Dodson et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Lrrk²/Lrrk¹ has semi-sterile phenotype, suppressible by Scer\GAL4^CY2/Hsap\LRRK2^UAS.Tag:HA

(Dodson et al., 2014)

Suppressor of

Statement

Reference

Lrrk[+]/Lrrk¹ is a suppressor of abnormal neurophysiology | dominant | third instar larval stage phenotype of Vps35^MH20

(Inoshita et al., 2017)

Lrrk[+]/Lrrk¹ is a suppressor of abnormal locomotor behavior | dominant | third instar larval stage phenotype of Vps35^MH20

(Inoshita et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Lrrk¹ heterozygosity suppresses both the decreased locomotor activity and the decreased excitatory junction potential amplitude under high stimulation of neuromuscular junctions presented by Vps35^MH20 heterozygous third instar larvae.

(Inoshita et al., 2017)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\LRRK2^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^CY2 rescues the semi-sterility phenotype of Lrrk¹/Lrrk² mutants.

(Dodson et al., 2014)

Complementation and Rescue Data

Rescued by

Lrrk²/Lrrk¹ is rescued by Scer\GAL4^CY2/Lrrk^UAS.cDa

(Dodson et al., 2014)

Lrrk²/Lrrk¹ is rescued by Scer\GAL4^CY2/Lrrk^G1914S.UAS

(Dodson et al., 2014)

Comments

Expression of Lrrk^{G1914S.Scer\UAS} under the control of Scer\GAL4^CY2 rescues the semi-sterility phenotype of Lrrk¹/Lrrk² mutants.

Expression of Lrrk^Scer\UAS.cDa under the control of Scer\GAL4^CY2 rescues the semi-sterility phenotype of Lrrk¹/Lrrk² mutants.

(Dodson et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Lrrk¹

Lrrk^NS1

(Inoshita et al., 2022)

dLRRK¹

(Inoshita et al., 2017)

lrrk¹

(Dodson et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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