FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LrrkHMS00456
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General Information
Symbol
Dmel\LrrkHMS00456
Species
D. melanogaster
Name
FlyBase ID
FBal0248212
Feature type
allele
Associated gene
Dmel\Lrrk
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00456}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS00456}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00456
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsc70-5KK100233
      (Zhu et al., 2021)
      exacerbates  mitochondrial DNA depletion syndrome 15
      modeled by TFAMNIG.4217R, TFAMc01716
      (Duncan et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females heterozygous for LrrkHMS00456 and MTD-Gal4 (consists of Scer\GAL4otu.T:Hsim\VP16, Scer\GAL4nos.PG and Scer\GAL4nos.UTR.T:Hsim\VP16) crossed to LrrkHMS00456 males results in: 90% hatching; non-maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mef2.PR/LrrkHMS00456 is a non-suppressor of mitochondrion | adult stage phenotype of Pink1B9

      (Ham et al., 2021)

      Scer\GAL4Mef2.PR/LrrkHMS00456 is a non-suppressor of flight muscle cell | adult stage phenotype of Pink1B9

      (Ham et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      LrrkHMS00456
      Name Synonyms
      Secondary FlyBase IDs
        References (7)