dFUS, P19, Sarcoma-associated RNA-binding fly homolog, SARFH
Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.
Gene model reviewed during 5.47
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\caz using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\caz in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Synaptic transmission at the larval neuromuscular junction is severely impaired in caz mutant flies.
caz has been cloned and sequenced, and its expression pattern has been analysed.
caz gene product contains a glycine rich C-terminal domain, but only one RNA recognition motif (RRM) located in the central portion. Intron and exon borders of full length cDNA and genomic clones have been determined and the predicted protein has 403 amino acids and is 48.4kD. UV crosslinking experiments demonstrate general RNA binding activity for the full length protein and the RRM domain.