FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cazP398L.UAS.Tag:HA
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General Information
Symbol
Dmel\cazP398L.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0324822
Feature type
allele
Associated gene
Dmel\caz
Associated Insertion(s)
Carried in Construct
P{UAS-HA-caz.P398L}
PBac{UAS-HA-caz.P398L}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Jäckel et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Jäckel et al., 2015)
Mutagen
in vitro construct
(Jäckel et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-HA-caz.P398L}
PBac{UAS-HA-caz.P398L}
Cytology
Description

UASt regulatory sequences drive expression of caz that carries the P398L mutation (this is equivalent to the disease-related P525L variant of the human Hsap\FUS ortholog). The protein is tagged at the N-terminal end with Tag:HA.

(Jäckel et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
caz
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,293,188..16,293,188 [+]
Nucleotide change:

C16293188T

Amino acid change:

P398L | caz-PB; P383L | caz-PC; P354L | caz-PD

Reported amino acid change:

P383L

Comment:

P383L mutation reported relative to caz-PB. Analogous mutation in human FUS implicated in amyotrophic lateral sclerosis 6; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.

(Jäckel et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Jäckel et al., 2015)
      FUS:p.Pro525Leu
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      FUS:p.Pro521Leu
      FUS:p.Pro524Leu
      Associated human disease model(s)
      External database links
      ClinVar: FUS_280110
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of cazP398L.Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.PF results in severe eye defects that include a rough eye phenotype with tissue gaps and considerable loss of pigmentation, as compared to controls.

      (Jäckel et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cazP398L.Scer\UAS.T:Ivir\HA1
      cazP398L.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)