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FB2026_01
,
released March 12, 2026
Iro-C, iro, iroquois, mrr, Sail
homeodomain, Pbx class - a component of the Iroquois complex - primary determiner of the border between dorsal and ventral halves of the eye - required in the dorsal mesoderm to ensure normal heart development in Drosophila.
Please see the JBrowse view of Dmel\mirr for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Gene model reviewed during 5.45
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.56
3.9 (northern blot)
3.5 (unknown)
641 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mirr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
mirr is expressed as a single broad domain at the dorsal-anterior region of the follicle cells at stage 9. At stage 10A, mirr expression is repressed in the dorsal midline and elevated in the cells at the anterior border of this expression domain. By stage 10B, mirr is restricted to the single row of anterior cells on either side of the midline, and is almost absent by stage 11.
mirr transcript is expressed in all developmental stages. In the wing disc, mirr is expressed in regions that will give rise to the notum, the pleura, and the alula. In the eye-antennal disc, expression is restricted to the dorsal region. A EcollacZ enhancer trap line (EcollacZmirr-B1-12) parallels mirr transcript expression; EcollacZ expression in this line is also detected in a subset of sensory organ precursor cells in the lateral heminotum, including precursors of the presutural and postalar bristles.
mirr is expressed in an anterior and ventral patch corresponding to the presumptive anterior midgut invagination in cellular blastoderm stage embryos. Expression is also detected in the dorsal fold. At stage 10, a segmentally repeated pattern of mirr expression is detected, and colocalization with en protein places this expression in the anterior border of each segment. Shortly thereafter, delaminating neuroblasts express mirr. Expression is also seen in dorsal clusters. At germ band retraction, mirr is expressed in the ventra nerve cord, and transient expression is detected in the proventriculus. mirr is also expressed in larvae and adults, in parts of the wing, haltere, and genital imaginal discs, and the dorsal anterior follicle cells in the ovary. In eye imaginal discs, expression is detected in the dorsal anterior half of the disc.
along the dorsal side becomes restricted to segmental patches during stage 11 and vanishes from the dorsal mesoderm during mid-embryogenesis.
Comment: overall expression, but fainter at anterior and posterior ends of egg chamber
Comment: lateral posterior
JBrowse - Visual display of RNA-Seq signals
View Dmel\mirr in JBrowse3-38
3-33.1
3-37.9
Mapped using mirrSai2.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
mirr is required for the proper routing of class IV topographic axonal projections across the midline of the CNS.
mirr expression at SOP stages converts other lineages to produce neurons with class IV character.
mirr is required cell-autonomously for induction of all dorsal anterior follicle cell fates.
The localised expression of the three genes of the iroquois complex - IRO-C (ara, caup and mirr) specifies the identity of dorsal cells in the eye. Juxtaposition of IRO-C-expressing and non-expressing cells forms a straight border that promotes growth and serves as a pattern-organising centre in the eye disc.
When the Iroquois complex is absent, notum cells are transformed into hinge (tegula and sclerite) cells.
Based on genetic map position, expression, protein structure and function, mirr is considered a new member of the iroquois complex.
The phenotype of mirr mutations implicates it in wing and peripheral nervous system development. The genes of the IRO-C are coordinately regulated and implicated in similar developmental processes. They are regulated in the eye by the Pc-group and trx-group genes, but not by classical modifiers of position effect variegation. Ventral silencing of the whole IRO-C in the eye occurs at the level of chromatin structure in a manner similar to that of the homeotic gene complexes, perhaps by local compaction of the region into a heterochromatin-like structure involving Pc-group products.
Identification: Identified on basis of lethality caused by a P{lacW} insertion.
Defined by an insertion of P{lacW}.
Identification: Lethal enhancer trap insertion.
Source for merge of: mirr Sai crep
Source for identity of: mirr CG10601
'crepuscule' means 'twilight' in French. A member of the IRO-C (Iroquois complex).
