FB2026_03 , released September 17, 2026
CV Term Report
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Term neuroblast NB2-3 ID (Ontology) FBbt:00001421 (Fly Anatomy)
Definition Neuroblast that delaminates at S5 and produces a primary lineage, of approximately 10 neurons, in thoracic segments only (Schmid et al., 1999; Birkholz et al., 2013; Lacin and Truman, 2016; Urbach et al., 2016). These primary neurons are mainly immature motor neurons that will connect to muscle targets in the adult (Lacin and Truman, 2016). In abdominal hemisegments it can be observed at embryonic stage 17, but it either does not divide or all progeny die (Schmid et al., 1999). In the larva, it resumes proliferation in all thoracic segments and generates postembryonic lineage 15, consisting of a large number of leg motor neurons and glia (Lacin and Truman, 2016).[ FlyBase:FBrf0055900 FlyBase:FBrf0084809 FlyBase:FBrf0112030 FlyBase:FBrf0221210 FlyBase:FBrf0228122 FlyBase:FBrf0231327 FlyBase:FBrf0232096 ]
Also Known As"lineage 15 neuroblast" ; "lineage NB2-3 neuroblast" ; "NB 15" (for all, see Synonyms field below)
CommentOriginally referred to as NB1-2 by Doe (1992), this was renamed to NB2-3 by Broadus et al. (1995) to keep the names of row 2 neuroblasts consistent with their position in Schistocerca. Birkholz et al. (2015) suggest that NB2-3 does not generate a postembryonic lineage and NB3-2 generates postembryonic lineage 15, but Lacin and Truman (2016) provide lineage tracing and marker data showing that NB2-3 generates lineage 15.
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VFB:FBbt_00001421
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
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 neuroblast NB2-3 (all annotations which use CV term, excluding "NOT" statements)
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central nervous system
 |__segmentally-repeated neuroblast__
neuroblast                           |
 |__stage 5 neuroblast_______________|
 |__neuroglioblast___________________|
 |__segmentally-repeated neuroblast__|
ectodermal derivative                |
 |__segmentally-repeated neuroblast__|
                                     neuroblast NB2-3  16 rec.
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segmentally-repeated neuroblast
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VFB:FBbt_00001421