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FB2026_01
,
released March 12, 2026
l(3)Lh7, l7
homeodomain transcription factor - optic lobe - pharyngeal primordia - central nervous system - brain - regulates Pdf neuropeptide expression controlling circadian rhythms
Please see the JBrowse view of Dmel\scro for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.50
Gene model reviewed during 6.02
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scro using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
scro expression is observed in the optic lobes in wandering third instar larvae. In prepupae, the optic lobe expression has intensified and there is also weak expression in clusters in the thoracic ganglia. In the adult brain, expression is pronounced in the medulla and in protocerebral clusters of cells.
Expression of scro transcript initiates at embryonic stage 9, in a dorsal anterior patch of cells. scro continues to be expressed at the anterior end of the embryo, in cells corresponding to presumptive pharyngeal tissues. Pharyngeal expression continues until late embryonic stages. During embryonic stage 11, scro transcript appears in bilaterally symmetrical cluster in the neurogenic regions of the embryonic head. These resolve into a large posterior cluster, and several smaller anterior clusters in the embryonic brain. Double-labelling with Fas2 indicates that scro is expressed in the posterior protocerebrum. By embryonic stage 14, scro is also expressed in the ventral nerve cord, in a pair of neuronal precursors per hemisegment; these neuroblasts appear to derive from the lateral cells of neuroblast row 5. In third instar larvae, scro is expressed in the larval outer optic anlage and medulla anlage.
JBrowse - Visual display of RNA-Seq signals
View Dmel\scro in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
One of a series of EMS-induced lethals detected by failure to complement proximal heterochromatic deficiencies in 3L or 3R, which resulted from detachments, i.e., reconstitutions of normal third chromosomes, from irradiated C(3L)RM/C(3R)RM-bearing females; a large set of such proximal heterochromatic deficiencies was employed in deficiency mapping of these lethals (Marchant and Holm, 1988).
Source for merge of: scro CG18452
Source for merge of: scro CG17594
Source for merge of: CG17594 CG17595
Source for merge of: scro l(3)80Fb
Annotations CG17594 and CG17595 merged as CG17594 (which corresponds to scro) in release 3 of the genome annotation.
Source for merge of scro CG17594 was sequence comparison ( date:001104 ).
Source for merge of scro CG18452 was sequence comparison ( date:000721 ).
