FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\zfh2
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General Information
Symbol
Dmel\zfh2
Species
D. melanogaster
Name
Zn finger homeodomain 2
Annotation Symbol
CG1449
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004607
Gene Model Status
Current
Stock Availability
35 publicly available
Gene Summary
Zn finger homeodomain 2 (zfh2) encodes a putative transcription factor. Its roles include specification of cell fates and promotion of apoptosis during CNS development, and proximal-distal patterning during wing and leg imaginal disc development. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

zfh-2, zinc finger homeodomain 2

Key Links
Genomic Location
Cytogenetic map
102C3-102C4
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:501810..540874
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding
inferred from direct assay
(Lundell and Hirsh, 1992)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA binding
traceable author statement
(Lai et al., 1991)
inferred from electronic annotation with InterPro:IPR001356
(InterPro Project Members, 2004-)
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from electronic annotation with InterPro:IPR017970
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000654739
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000654739
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Whitworth and Russell, 2003)
involved_in nervous system development
inferred from expression pattern
(Lai et al., 1991)
involved_in wing disc development
inferred from mutant phenotype
(Perea et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR017970
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000654739
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Lai et al., 1991)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000654739
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Zn finger homeodomain 2 (zfh2) encodes a putative transcription factor. Its roles include specification of cell fates and promotion of apoptosis during CNS development, and proximal-distal patterning during wing and leg imaginal disc development. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
ZINC FINGER HOMEOBOX TRANSCRIPTION FACTORS -
Zinc finger homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. This class includes proteins with homeodomain and C2H2 and C2H2-like zinc finger motifs. (Adapted from FBrf0232555 and PMID:18797923).
Protein Function (UniProtKB)
Involved in the development of the embryonic central nervous system.
(UniProt, P28167)
Summary (Interactive Fly)

transcription factor - zinc finger domain and homeodomain - required for correct proximal wing development - a mediator of hypercapnic (elevated CO2) immune regulation

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\zfh2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P28167)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
zfh2-RA
FBtr0089070
NM_079884
10619
3005
zfh2-RB
FBtr0307167
NM_001258496
11695
3003
zfh2-RC
FBtr0332913
NM_001272130
10141
2805
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
zfh2-PA
FBpp0088139
332.0
3005
6.57
P28167
NP_524623
AAF59339
zfh2-PB
FBpp0297996
331.8
3003
6.59
H9XVP0
NP_001245425
AFH06785
zfh2-PC
FBpp0305133
309.5
2805
6.56
L0MLK7
NP_001259059
AGB96549
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

3005 (aa)

(Lundell and Hirsh, 1992)

3005 (aa); 332 (kD predicted)

(Fortini et al., 1991)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zfh2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.86

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
hindgut anlage in statu nascendi
(Fisher et al., 2012)
posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
central brain anlage
(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 15
presumptive embryonic/larval central nervous system
(Lai et al., 1991)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic large intestine
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
larval midline neuron
(Kearney et al., 2004)
embryonic stage 15
embryonic/larval hindgut
(Lai et al., 1991)
third instar larval stage
wing disc | restricted
(Klebes et al., 2002)
antennal disc | restricted
(Klebes et al., 2002)
Additional Descriptive Data

The zfh2 transcript distribution pattern corresponds closely to that of zfh2 protein.

(Lai et al., 1991)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval serotonergic A3 neuron -- larval serotonergic A6 neuron
(Lundell and Hirsh, 1992)
larval central nervous system
(Lundell and Hirsh, 1992)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system | lateral
(Lundell and Hirsh, 1992)
embryonic stage 13 -- 15
presumptive embryonic/larval central nervous system
(Lai et al., 1991)
embryonic stage 13 -- 16
embryonic dorsal longitudinal glial cell
(Beckervordersandforth et al., 2008)
embryonic ventral longitudinal glial cell
(Beckervordersandforth et al., 2008)
embryonic lateral longitudinal glial cell
(Beckervordersandforth et al., 2008)
longitudinal glial cell

Comment: lateral posterior

(Beckervordersandforth et al., 2008)
medial intersegmental nerve root glial cell
(Beckervordersandforth et al., 2008)
larval neuron
(Beckervordersandforth et al., 2008)
embryonic stage 15
embryonic/larval hindgut
(Lai et al., 1991)
embryonic stage 15 -- 17
EW2 neuron
(Lundell et al., 2003)
EW3 neuron
(Lundell et al., 2003)
embryonic stage 16
larval DA2 motor neuron
(Touma et al., 2012)
larval DA3 motor neuron
(Touma et al., 2012)
embryonic stage 17
EW2 neuron
(Karcavich and Doe, 2005, Lundell and Hirsh, 1998)
EW3 neuron
(Karcavich and Doe, 2005, Lundell and Hirsh, 1998)
larval stage
abdominal 3 neuroblast NB3-5 -- abdominal 7 neuroblast NB3-5
(Lundell and Hirsh, 1992)
second instar larval stage
wing pouch | restricted
(Terriente et al., 2008)
third instar larval stage
larval serotonergic VNC neuron | subset
(Lundell and Hirsh, 1998)
dopaminergic neuron | subset
(Lundell and Hirsh, 1998)
wing hinge primordium
(Terriente et al., 2008)
leg disc
(Guarner et al., 2014)
prepupal stage
tarsal segment | distal | segmentally repeated
(Guarner et al., 2014)
adult stage | male & spermatogenesis
cyst progenitor cell
(Zhang et al., 2013)
Additional Descriptive Data

At the early third larval stage, there is a faint zfh2 signal in the centre of the leg discs, which is more readily visible at the middle of this stage, when it coincides with Dll expression. As the leg disc matures, several outer rings of zfh2 expression are successively observed. In accordance with the pupal ScerGAL4zfh2-LP30 expression in leg joints, strong zfh2 expression is observed in cells of everting pupal leg discs that will contribute to the formation of the joints, with more intense signal in cells abutting those forming the tarsal folds and weaker signal more proximally and distally in each tarsal segment. There is also strong signal in the pretarsus, the distal part of the leg, and in the leg tendon that reaches the pretarsus.

(Guarner et al., 2014)

In 2nd instar larvae the zfh2 domain is broader than but includes the nub and rn domains in the presumptive wing. Later it corresponds to the wing hinge. The zfh2 expression domain is largely complementary to the dve and nab domains during larval development.

(Terriente et al., 2008)

Markers that uniquely identify the cells of the NB3-7 lineage were used to examine the serotonin expressing cell lineages.

(Lundell et al., 2003)

zfh2 is expressed in the lateral, but not the medial, of the paired ventro-lateral serotonergic neurons.

(Lundell and Hirsh, 1998)

zfh2 protein isexpressed in about 50 cells/segment in the lateral embryonic CNS atpositions consistent with the subsequent location of serotonin cells. Inlarvae, it is expressed in a dispersed pattern in about 20% of the cellsin the ventral ganglion. A subset of these also express Ddc and includedopamine and seratonin neurons.

(Lundell and Hirsh, 1992)

zfh2 protein is first detected in the CNS at the middle of germ band retraction. It is present in at least 50 neurons per hemisegment as well as in cells of the brain. It is also detected at lower levels in the hindgut of older embryos

(Lai et al., 1991)
Marker for
 
larval DA2 motor neuron
(Touma et al., 2012)
larval DA3 motor neuron
(Touma et al., 2012)
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Lai et al., 1991)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\zfh2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 24 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of zfh2
Transgenic constructs containing regulatory region of zfh2
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(4)C1-7a
(Sousa-Neves et al., 2005)
Df(4)C1-10a
(Sousa-Neves et al., 2005, Podemski et al., 2004)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(4)ED6380)
lethal (with Df(4)ED6382)
lethal (with zfh23A)
lethal (with zfh251A)
lethal (with zfh2A)
lethal (with zfh2D)
lethal (with zfh2vii-2)
lethal | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during embryonic stage
lethal - all die during embryonic stage (with Df(4)C1-7a)
partially lethal
partially lethal - majority die, with Scer\GAL4zfh2-LP30
viable
viable, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
abnormal cell number | embryonic stage
abnormal cell number | embryonic stage, with Scer\GAL4eg-Mz360
abnormal cell shape | adult stage, with Scer\GAL4Su(H).GBE
abnormal cell shape | adult stage | chemical conditional, with Scer\GAL4Su(H).GBE
chemical resistant | adult stage, with Scer\GAL4Su(H).GBE
decreased cell death | embryonic stage
decreased cell size | adult stage, with Scer\GAL4esg.PU
decreased cell size | adult stage, with Scer\GAL4Su(H).GBE
decreased occurrence of cell division | adult stage | chemical conditional, with Scer\GAL4Su(H).GBE
decreased occurrence of cell division | third instar larval stage, with Scer\GAL4hh.PU
decreased size | adult stage, with Scer\GAL4en.PU
increased cell growth rate | adult stage, with Scer\GAL4Su(H).GBE
increased cell size | adult stage, with Scer\GAL4esg.PU
increased cell size | adult stage, with Scer\GAL4Su(H).GBE
increased occurrence of cell division | adult stage, with Scer\GAL4Su(H).GBE
increased occurrence of cell division | third instar larval stage, with Scer\GAL4hh.PU
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage, with Scer\GAL4zfh2-LP30
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4nub-AC-62
visible, with Scer\GAL4salm.EPv
visible | adult stage, with Scer\GAL4Dll.PU
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4ptc.PU
visible | adult stage A1, with Scer\GAL4zfh2-LP30
Phenotype manifest in
Allele
adult anterior midgut epithelium, with Scer\GAL4esg.PU
adult gut, with Scer\GAL4esg.PU
adult gut, with Scer\GAL4Su(H).GBE
adult posterior midgut epithelium, with Scer\GAL4esg.PU
adult posterior midgut epithelium, with Scer\GAL4Su(H).GBE
alar lobe
antenna, with Scer\GAL4en.PU
arista, with Scer\GAL4en.PU
axon | embryonic stage
chaeta | ectopic, with Scer\GAL4salm.EPv
chorionic layer | somatic clone, with Scer\GAL4Act5C.PP
connective | embryonic stage
embryonic ventral nerve cord
embryonic ventral nerve cord, with Scer\GAL4eg-Mz360
enteroblast, with Scer\GAL4Su(H).GBE
enteroblast | adult stage, with Scer\GAL4esg.PU
enteroblast | adult stage, with Scer\GAL4Su(H).GBE
enteroblast | adult stage, with Scer\GAL4T80
eye, with Scer\GAL4ey.PU
eye, with Scer\GAL4GMR.PU
follicle cell | somatic clone, with Scer\GAL4Act5C.PP
haltere, with Scer\GAL4en.PU
intestinal stem cell | adult stage, with Scer\GAL4esg.PU
intestinal stem cell | adult stage, with Scer\GAL4Su(H).GBE
intestinal stem cell | adult stage | chemical conditional, with Scer\GAL4Su(H).GBE
leg, with Scer\GAL4en.PU
leg, with Scer\GAL4ptc-559.1
leg joint, with Scer\GAL4en.PU
medial costal vein
nucleus | adult stage, with Scer\GAL4esg.PU
nucleus | adult stage, with Scer\GAL4Su(H).GBE
plasma membrane | adult stage, with Scer\GAL4Su(H).GBE
plasma membrane | adult stage | chemical conditional, with Scer\GAL4Su(H).GBE
sclerite, with Scer\GAL4zfh2-LP30
segment of leg, with Scer\GAL4en.PU
tarsal segment, with Scer\GAL4Dll.PU
tarsal segment, with Scer\GAL4ptc.PU
tibia-tarsus joint, with Scer\GAL4en.PU
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4salm.EPv
wing, with Scer\GAL4zfh2-LP30
wing | proximal
wing disc
wing disc, with Scer\GAL4hh.PU
wing hinge, with Scer\GAL4nub-AC-62
wing hinge, with Scer\GAL4zfh2-LP30
wing vein L1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (125)
Hsap\ZFHX3
12 of 14
Yes
Yes
1  
Hsap\ZFHX4
10 of 14
No
Yes
Hsap\ZFHX2
7 of 14
No
Yes
1  
Hsap\ABLIM3
1 of 14
No
No
Hsap\ALX1
1 of 14
No
No
Hsap\ALX4
1 of 14
No
No
Hsap\ARGFX
1 of 14
No
Yes
Hsap\BARX1
1 of 14
No
No
Hsap\BARX2
1 of 14
No
No
Hsap\BSX
1 of 14
No
No
Hsap\CDX4
1 of 14
No
No
Hsap\CRX
1 of 14
No
No
5  
Hsap\DBX2
1 of 14
No
No
Hsap\DLX2
1 of 14
No
No
Hsap\DLX3
1 of 14
No
No
1  
Hsap\DLX5
1 of 14
No
No
Hsap\DLX6
1 of 14
No
No
Hsap\DMBX1
1 of 14
No
No
Hsap\DPRX
1 of 14
No
Yes
Hsap\DRGX
1 of 14
No
No
Hsap\DUX4
1 of 14
No
No
2  
Hsap\DUX4L4
1 of 14
No
Yes
Hsap\DUX4L7
1 of 14
No
Yes
Hsap\DUX4L9
1 of 14
No
Yes
Hsap\DUXA
1 of 14
No
Yes
Hsap\EMX1
1 of 14
No
No
Hsap\EMX2
1 of 14
No
No
Hsap\GBX1
1 of 14
No
No
Hsap\GSC
1 of 14
No
No
Hsap\GSX1
1 of 14
No
No
Hsap\GSX2
1 of 14
No
No
Hsap\HHEX
1 of 14
No
No
Hsap\HLX
1 of 14
No
No
Hsap\HMX2
1 of 14
No
No
Hsap\HOXA3
1 of 14
No
No
Hsap\HOXA4
1 of 14
No
No
Hsap\HOXA5
1 of 14
No
No
1  
Hsap\HOXA7
1 of 14
No
No
Hsap\HOXA10
1 of 14
No
No
1  
Hsap\HOXA11
1 of 14
No
No
1  
Hsap\HOXA13
1 of 14
No
No
Hsap\HOXB2
1 of 14
No
No
1  
Hsap\HOXB3
1 of 14
No
No
Hsap\HOXB4
1 of 14
No
No
Hsap\HOXB5
1 of 14
No
No
1  
Hsap\HOXB6
1 of 14
No
No
1  
Hsap\HOXB7
1 of 14
No
No
Hsap\HOXB8
1 of 14
No
No
Hsap\HOXB9
1 of 14
No
No
1  
Hsap\HOXC4
1 of 14
No
No
Hsap\HOXC5
1 of 14
No
No
Hsap\HOXC6
1 of 14
No
No
Hsap\HOXC11
1 of 14
No
No
Hsap\HOXC13
1 of 14
No
Yes
Hsap\HOXD1
1 of 14
No
No
Hsap\HOXD3
1 of 14
No
No
Hsap\HOXD4
1 of 14
No
No
2  
Hsap\HOXD8
1 of 14
No
No
Hsap\HOXD10
1 of 14
No
No
1  
Hsap\HOXD11
1 of 14
No
No
Hsap\ISL1
1 of 14
No
No
Hsap\ISL2
1 of 14
No
No
1  
Hsap\ISX
1 of 14
No
No
Hsap\LBX1
1 of 14
No
No
Hsap\LBX2
1 of 14
No
No
2  
Hsap\LDB3
1 of 14
No
No
1  
Hsap\LEUTX
1 of 14
No
No
Hsap\LHX1
1 of 14
No
No
1  
Hsap\LHX2
1 of 14
No
No
1  
Hsap\LHX3
1 of 14
No
No
Hsap\LHX4
1 of 14
No
No
Hsap\LHX5
1 of 14
No
No
Hsap\LHX6
1 of 14
No
No
1  
Hsap\LHX8
1 of 14
No
No
Hsap\LHX9
1 of 14
No
No
1  
Hsap\LIMK1
1 of 14
No
No
Hsap\LMO1
1 of 14
No
No
1  
Hsap\LMO2
1 of 14
No
No
1  
Hsap\LMO3
1 of 14
No
No
1  
Hsap\LMO4
1 of 14
No
No
Hsap\LMX1A
1 of 14
No
No
Hsap\LMX1B
1 of 14
No
No
Hsap\MEOX1
1 of 14
No
No
1  
Hsap\MIXL1
1 of 14
No
No
Hsap\MSX2
1 of 14
No
No
Hsap\NANOG
1 of 14
No
No
Hsap\NANOGP1
1 of 14
No
Yes
Hsap\NANOGP8
1 of 14
No
No
Hsap\NKX2-1
1 of 14
No
No
Hsap\NKX2-4
1 of 14
No
No
Hsap\NKX6-1
1 of 14
No
No
1  
Hsap\NKX6-2
1 of 14
No
No
Hsap\NKX6-3
1 of 14
No
No
Hsap\NOBOX
1 of 14
No
No
Hsap\NOTO
1 of 14
No
No
Hsap\OTX1
1 of 14
No
No
3  
Hsap\OTX2
1 of 14
No
No
3  
Hsap\PAX3
1 of 14
No
No
1  
Hsap\PAX4
1 of 14
No
No
Hsap\PAX6
1 of 14
No
No
2  
Hsap\PDLIM5
1 of 14
No
No
Hsap\PDLIM7
1 of 14
No
No
Hsap\PDX1
1 of 14
No
No
Hsap\PHOX2A
1 of 14
No
No
Hsap\PHOX2B
1 of 14
No
No
Hsap\PITX2
1 of 14
No
No
1  
Hsap\PITX3
1 of 14
No
No
1  
Hsap\PRICKLE2
1 of 14
No
No
Hsap\PRRX2
1 of 14
No
No
Hsap\PXN
1 of 14
No
No
Hsap\RAX2
1 of 14
No
No
Hsap\RAX
1 of 14
No
No
1  
Hsap\SEBOX
1 of 14
No
Yes
Hsap\SHOX2
1 of 14
No
No
Hsap\SHOX
1 of 14
No
No
1  
Hsap\TLX1
1 of 14
No
No
Hsap\TLX2
1 of 14
No
No
Hsap\TLX3
1 of 14
No
No
Hsap\TRIO
1 of 14
No
No
1  
Hsap\TRIP6
1 of 14
No
No
1  
Hsap\UNCX
1 of 14
No
No
Hsap\VAX1
1 of 14
No
No
Hsap\VAX2
1 of 14
No
No
Hsap\VENTX
1 of 14
No
No
Hsap\WTIP
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (41)
Rnor\Zfhx4
11 of 14
Yes
Yes
Rnor\Zfhx3
10 of 14
No
Yes
Rnor\Zfhx2
7 of 14
No
Yes
Rnor\Bsx
1 of 14
No
No
Rnor\Crx
1 of 14
No
No
Rnor\Dmbx1
1 of 14
No
No
Rnor\Drgx
1 of 14
No
No
Rnor\Dux4
1 of 14
No
No
Rnor\Emx2
1 of 14
No
No
Rnor\Gbx1
1 of 14
No
No
Rnor\Hhex
1 of 14
No
No
Rnor\Hoxa3
1 of 14
No
Yes
Rnor\Hoxa11
1 of 14
No
No
Rnor\Hoxb1
1 of 14
No
No
Rnor\Hoxb3
1 of 14
No
No
Rnor\Hoxb5
1 of 14
No
No
Rnor\Hoxb6
1 of 14
No
No
Rnor\Hoxb9
1 of 14
No
No
Rnor\Hoxc6
1 of 14
No
No
Rnor\Hoxc10
1 of 14
No
No
Rnor\Hoxc11
1 of 14
No
No
Rnor\Hoxd4
1 of 14
No
No
Rnor\Hoxd8
1 of 14
No
No
Rnor\Hoxd10
1 of 14
No
No
Rnor\Hoxd11
1 of 14
No
No
Rnor\Lbx1
1 of 14
No
No
Rnor\Lhx2
1 of 14
No
No
Rnor\Lhx3
1 of 14
No
No
Rnor\Lhx4
1 of 14
No
No
Rnor\Nkx1-1
1 of 14
No
No
Rnor\Nkx1-2
1 of 14
No
No
Rnor\Nkx2-1
1 of 14
No
No
Rnor\Nkx2-8
1 of 14
No
No
Rnor\Nobox
1 of 14
No
No
Rnor\Otx1
1 of 14
No
No
Rnor\Pax6
1 of 14
No
No
Rnor\Pitx3
1 of 14
No
No
Rnor\Prop1
1 of 14
No
No
Rnor\Tlx1
1 of 14
No
No
Rnor\Vax1
1 of 14
No
No
Rnor\Vax2
1 of 14
No
No
Mus musculus (laboratory mouse) (55)
Mmus\Zfhx3
11 of 14
Yes
Yes
Mmus\Zfhx4
10 of 14
No
Yes
Mmus\Zfhx2
7 of 14
No
Yes
Mmus\Cdx4
1 of 14
No
No
Mmus\Crx
1 of 14
No
No
Mmus\Dmbx1
1 of 14
No
No
Mmus\Duxbl1
1 of 14
No
No
Mmus\Emx2
1 of 14
No
No
1  
Mmus\Gbx1
1 of 14
No
No
Mmus\Hoxa3
1 of 14
No
No
Mmus\Hoxa10
1 of 14
No
No
Mmus\Hoxa11
1 of 14
No
No
Mmus\Hoxb2
1 of 14
No
No
Mmus\Hoxb3
1 of 14
No
No
0  
Mmus\Hoxb5
1 of 14
No
No
Mmus\Hoxb6
1 of 14
No
No
1  
Mmus\Hoxb9
1 of 14
No
No
1  
Mmus\Hoxc6
1 of 14
No
No
Mmus\Hoxc10
1 of 14
No
No
Mmus\Hoxc11
1 of 14
No
No
Mmus\Hoxd3
1 of 14
No
No
Mmus\Hoxd10
1 of 14
No
No
1  
Mmus\Hoxd11
1 of 14
No
No
Mmus\Isx
1 of 14
No
No
Mmus\Lbx1
1 of 14
No
No
Mmus\Lhx2
1 of 14
No
No
Mmus\Lhx3
1 of 14
No
No
Mmus\Lhx4
1 of 14
No
No
Mmus\Mnx1
1 of 14
No
No
Mmus\Nanog
1 of 14
No
No
Mmus\Nkx2-1
1 of 14
No
No
Mmus\Nobox
1 of 14
No
No
Mmus\Noto
1 of 14
No
No
Mmus\Obox1
1 of 14
No
No
Mmus\Obox3
1 of 14
No
Yes
Mmus\Obox5
1 of 14
No
No
Mmus\Otx1
1 of 14
No
No
Mmus\Otx2
1 of 14
No
No
Mmus\Pax4
1 of 14
No
No
Mmus\Pax6
1 of 14
No
No
3  
Mmus\Pdx1
1 of 14
No
No
Mmus\Pitx3
1 of 14
No
No
Mmus\Prop1
1 of 14
No
No
Mmus\Prrxl1
1 of 14
No
No
Mmus\Rhox3a2
1 of 14
No
Yes
Mmus\Rhox3a
1 of 14
No
Yes
Mmus\Rhox3c
1 of 14
No
Yes
Mmus\Rhox3e
1 of 14
No
Yes
Mmus\Rhox3f
1 of 14
No
Yes
Mmus\Rhox3g
1 of 14
No
Yes
Mmus\Rhox3h
1 of 14
No
Yes
Mmus\Rhox7a
1 of 14
No
Yes
Mmus\Rhox7b
1 of 14
No
Yes
Mmus\Vax1
1 of 14
No
No
1  
Mmus\Vax2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (88)
Xtro\zfhx3
9 of 13
Yes
Yes
Xtro\zfhx4
9 of 13
Yes
Yes
Xtro\zfhx2
4 of 13
No
Yes
Xtro\ablim2
1 of 13
No
No
Xtro\alx4
1 of 13
No
No
Xtro\barhl2
1 of 13
No
No
Xtro\barx1
1 of 13
No
No
Xtro\barx2
1 of 13
No
No
Xtro\bsx
1 of 13
No
No
Xtro\cdx4
1 of 13
No
No
Xtro\crx
1 of 13
No
No
Xtro\crybb2
1 of 13
No
No
Xtro\dbx1
1 of 13
No
No
Xtro\dbx2
1 of 13
No
No
Xtro\dlx2
1 of 13
No
No
Xtro\dlx5
1 of 13
No
No
Xtro\dlx6
1 of 13
No
No
Xtro\dmbx1
1 of 13
No
No
Xtro\drgx
1 of 13
No
No
Xtro\emx1l
1 of 13
No
No
Xtro\emx1
1 of 13
No
No
Xtro\evx1
1 of 13
No
No
Xtro\gsx1
1 of 13
No
No
Xtro\hhex
1 of 13
No
No
Xtro\hmx2
1 of 13
No
No
Xtro\hmx3
1 of 13
No
No
Xtro\homeobox100496651-provisional
1 of 13
No
No
Xtro\hoxa1
1 of 13
No
No
Xtro\hoxa3
1 of 13
No
No
Xtro\hoxa4
1 of 13
No
No
Xtro\hoxa5
1 of 13
No
No
Xtro\hoxa7
1 of 13
No
No
Xtro\hoxb2
1 of 13
No
No
Xtro\hoxb3
1 of 13
No
No
Xtro\hoxb5
1 of 13
No
No
Xtro\hoxb8
1 of 13
No
No
Xtro\hoxc3
1 of 13
No
No
Xtro\hoxc5
1 of 13
No
No
Xtro\hoxc12
1 of 13
No
Yes
Xtro\hoxc13
1 of 13
No
Yes
Xtro\hoxd3
1 of 13
No
No
Xtro\isl2
1 of 13
No
No
Xtro\lbx1
1 of 13
No
No
Xtro\ldb3
1 of 13
No
No
Xtro\lhx1
1 of 13
No
No
Xtro\lhx5
1 of 13
No
No
Xtro\lhx6
1 of 13
No
No
Xtro\lhx8
1 of 13
No
No
Xtro\lhx9
1 of 13
No
No
Xtro\limd1
1 of 13
No
No
Xtro\lmo2
1 of 13
No
No
Xtro\lmo4.2
1 of 13
No
No
Xtro\lmx1a
1 of 13
No
No
Xtro\lmx1b.1
1 of 13
No
No
Xtro\lmx1b.2
1 of 13
No
No
Xtro\LOC100485697
1 of 13
No
No
Xtro\LOC100486032
1 of 13
No
No
Xtro\LOC100490929
1 of 13
No
No
Xtro\LOC101731251
1 of 13
No
No
Xtro\LOC116406456
1 of 13
No
Yes
Xtro\med9
1 of 13
No
No
Xtro\meox2
1 of 13
No
No
Xtro\mnx1
1 of 13
No
No
Xtro\msx1
1 of 13
No
No
Xtro\nkx1-1
1 of 13
No
No
Xtro\nkx2-1
1 of 13
No
No
Xtro\nkx2-3
1 of 13
No
No
Xtro\nkx3-3
1 of 13
No
No
Xtro\nkx6-2
1 of 13
No
No
Xtro\nkx6-3
1 of 13
No
No
Xtro\not
1 of 13
No
No
Xtro\otx2
1 of 13
No
No
Xtro\pax3
1 of 13
No
No
Xtro\pdlim5
1 of 13
No
No
Xtro\pdx1
1 of 13
No
No
Xtro\phox2b
1 of 13
No
No
Xtro\pitx2
1 of 13
No
No
Xtro\pitx3
1 of 13
No
No
Xtro\prickle1
1 of 13
No
No
Xtro\prop1
1 of 13
No
No
Xtro\prrx2
1 of 13
No
No
Xtro\rax2
1 of 13
No
No
Xtro\rax
1 of 13
No
No
Xtro\sia1
1 of 13
No
No
Xtro\tmem143
1 of 13
No
No
Xtro\uncx
1 of 13
No
No
Xtro\ventx3.2
1 of 13
No
No
Xtro\vsx2
1 of 13
No
No
Danio rerio (Zebrafish) (64)
Drer\zfhx3a
11 of 14
Yes
Yes
Drer\zfhx4
11 of 14
Yes
Yes
Drer\zfhx3b
10 of 14
No
Yes
Drer\alx1
1 of 14
No
No
Drer\barx1
1 of 14
No
No
Drer\cdx1a
1 of 14
No
No
Drer\cdx4
1 of 14
No
No
Drer\crx
1 of 14
No
No
Drer\dlx1a
1 of 14
No
No
Drer\dmbx1b
1 of 14
No
No
Drer\drgx
1 of 14
No
No
Drer\emx2
1 of 14
No
No
Drer\gbx1
1 of 14
No
No
Drer\gbx2
1 of 14
No
No
Drer\gsc
1 of 14
No
No
Drer\hlx1
1 of 14
No
No
Drer\hmx3b
1 of 14
No
No
Drer\hoxa3a
1 of 14
No
No
Drer\hoxa4a
1 of 14
No
No
Drer\hoxa9a
1 of 14
No
No
Drer\hoxa10b
1 of 14
No
No
Drer\hoxa11a
1 of 14
No
No
Drer\hoxa11b
1 of 14
No
No
Drer\hoxb3a
1 of 14
No
No
Drer\hoxb5b
1 of 14
No
No
Drer\hoxc3a
1 of 14
No
No
Drer\hoxc10a
1 of 14
No
No
Drer\hoxc11a
1 of 14
No
No
Drer\hoxc11b
1 of 14
No
No
Drer\hoxd3a
1 of 14
No
No
Drer\hoxd10a
1 of 14
No
No
Drer\hoxd11a
1 of 14
No
No
Drer\lbx1b
1 of 14
No
No
Drer\lhx2b
1 of 14
No
No
Drer\lhx3
1 of 14
No
No
Drer\lhx4
1 of 14
No
No
Drer\lhx9
1 of 14
No
No
Drer\LOC100008066
1 of 14
No
No
Drer\mixl1
1 of 14
No
No
Drer\nanog
1 of 14
No
No
Drer\nkx1.2la
1 of 14
No
No
Drer\nkx2.1
1 of 14
No
No
Drer\nkx2.2a
1 of 14
No
No
Drer\nkx2.2b
1 of 14
No
No
Drer\nkx2.4b
1 of 14
No
No
Drer\nkx2.5
1 of 14
No
No
Drer\nkx2.7
1 of 14
No
No
Drer\nkx3-1
1 of 14
No
No
Drer\nkx3-2
1 of 14
No
No
Drer\nkx3.3
1 of 14
No
No
Drer\otx1
1 of 14
No
No
Drer\otx2a
1 of 14
No
No
Drer\otx2b
1 of 14
No
No
Drer\otx5
1 of 14
No
No
Drer\pax7b
1 of 14
No
No
Drer\pdx1
1 of 14
No
No
Drer\phox2a
1 of 14
No
No
Drer\phox2bb
1 of 14
No
No
Drer\si:dkey-43p13.5
1 of 14
No
No
Drer\six1b
1 of 14
No
No
Drer\tlx3b
1 of 14
No
No
Drer\vax1
1 of 14
No
No
Drer\vax2
1 of 14
No
No
Drer\vox
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (44)
Cele\zfh-2
11 of 14
Yes
Yes
Cele\alr-1
1 of 14
No
No
Cele\ceh-1
1 of 14
No
No
Cele\ceh-2
1 of 14
No
No
Cele\ceh-8
1 of 14
No
No
Cele\ceh-9
1 of 14
No
No
Cele\ceh-14
1 of 14
No
No
Cele\ceh-17
1 of 14
No
No
Cele\ceh-19
1 of 14
No
No
Cele\ceh-23
1 of 14
No
No
Cele\ceh-24
1 of 14
No
No
Cele\ceh-27
1 of 14
No
No
Cele\ceh-34
1 of 14
No
No
Cele\ceh-36
1 of 14
No
No
Cele\ceh-37
1 of 14
No
No
Cele\ceh-43
1 of 14
No
No
Cele\ceh-44
1 of 14
No
No
Cele\ceh-45
1 of 14
No
No
Cele\ceh-51
1 of 14
No
No
Cele\ceh-53
1 of 14
No
No
Cele\ceh-54
1 of 14
No
No
Cele\ceh-60
1 of 14
No
No
Cele\ceh-62
1 of 14
No
No
Cele\cog-1
1 of 14
No
No
Cele\dsc-1
1 of 14
No
No
Cele\egl-5
1 of 14
No
No
Cele\eyg-1
1 of 14
No
No
Cele\hmbx-1
1 of 14
No
Yes
Cele\lim-4
1 of 14
No
No
Cele\lim-6
1 of 14
No
No
Cele\lim-7
1 of 14
No
No
Cele\lin-11
1 of 14
No
No
Cele\lin-39
1 of 14
No
No
Cele\mab-5
1 of 14
No
No
Cele\mec-3
1 of 14
No
No
Cele\mls-2
1 of 14
No
No
Cele\nob-1
1 of 14
No
No
Cele\pha-2
1 of 14
No
No
Cele\php-3
1 of 14
No
No
Cele\tab-1
1 of 14
No
No
Cele\ttx-3
1 of 14
No
No
Cele\unc-4
1 of 14
No
No
Cele\vab-3
1 of 14
No
No
Cele\zyx-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (37)
Agam\AgaP_AGAP000058
10 of 12
Yes
Yes
Agam\ABDA_ANOGA
1 of 12
No
No
Agam\AgaP_AGAP000190
1 of 12
No
No
Agam\AgaP_AGAP000731
1 of 12
No
No
Agam\AgaP_AGAP001389
1 of 12
No
No
Agam\AgaP_AGAP001483
1 of 12
No
No
Agam\AgaP_AGAP001618
1 of 12
No
No
Agam\AgaP_AGAP002372
1 of 12
No
No
Agam\AgaP_AGAP003574
1 of 12
No
No
Agam\AgaP_AGAP003670
1 of 12
No
No
Agam\AgaP_AGAP003671
1 of 12
No
No
Agam\AgaP_AGAP003672
1 of 12
No
No
Agam\AgaP_AGAP004646
1 of 12
No
No
Agam\AgaP_AGAP004648
1 of 12
No
No
Agam\AgaP_AGAP004661
1 of 12
No
No
Agam\AgaP_AGAP005096
1 of 12
No
No
Agam\AgaP_AGAP005137
1 of 12
No
No
Agam\AgaP_AGAP005138
1 of 12
No
No
Agam\AgaP_AGAP005281
1 of 12
No
No
Agam\AgaP_AGAP005425
1 of 12
No
No
Agam\AgaP_AGAP005727
1 of 12
No
No
Agam\AgaP_AGAP006536
1 of 12
No
No
Agam\AgaP_AGAP006537
1 of 12
No
No
Agam\AgaP_AGAP006540
1 of 12
No
No
Agam\AgaP_AGAP006901
1 of 12
No
No
Agam\AgaP_AGAP007985
1 of 12
No
No
Agam\AgaP_AGAP008980
1 of 12
No
No
Agam\AgaP_AGAP009088
1 of 12
No
No
Agam\AgaP_AGAP009302
1 of 12
No
No
Agam\AgaP_AGAP009646
1 of 12
No
No
Agam\AgaP_AGAP010209
1 of 12
No
No
Agam\AgaP_AGAP010358
1 of 12
No
No
Agam\AgaP_AGAP010391
1 of 12
No
No
Agam\AgaP_AGAP011134
1 of 12
No
No
Agam\AgaP_AGAP012501
1 of 12
No
No
Agam\AgaP_AGAP013157
1 of 12
No
No
Agam\AgaP_AGAP013373
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (19)
Atha\ANL2
1 of 13
Yes
No
Atha\ATHB-15
1 of 13
Yes
Yes
Atha\AtHB23
1 of 13
Yes
No
Atha\ATHB54
1 of 13
Yes
No
Atha\FWA
1 of 13
Yes
No
Atha\GL2
1 of 13
Yes
No
Atha\HAT3
1 of 13
Yes
No
Atha\HB-1
1 of 13
Yes
No
Atha\HB-3
1 of 13
Yes
No
Atha\HB5
1 of 13
Yes
No
Atha\HB-7
1 of 13
Yes
No
Atha\HB-8
1 of 13
Yes
No
Atha\HB52
1 of 13
Yes
No
Atha\HDG9
1 of 13
Yes
No
Atha\HDG11
1 of 13
Yes
No
Atha\PHB
1 of 13
Yes
No
Atha\PHV
1 of 13
Yes
No
Atha\REV
1 of 13
Yes
No
Atha\RLT2
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PHO2
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\phx1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:zfh2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (77)
ap
3 of 13
Awh
3 of 13
Lim1
3 of 13
Lim3
3 of 13
Lmx1a
3 of 13
abd-A
2 of 13
Antp
2 of 13
bsh
2 of 13
C15
2 of 13
cad
2 of 13
CG4328
2 of 13
CG11085
2 of 13
CG11294
2 of 13
CG18599
2 of 13
CG34031
2 of 13
CG34367
2 of 13
Dbx
2 of 13
Drgx
2 of 13
ems
2 of 13
ftz
2 of 13
H2.0
2 of 13
hbn
2 of 13
HHEX
2 of 13
lbe
2 of 13
NK7.1
2 of 13
Pph13
2 of 13
tup
2 of 13
Ubx
2 of 13
zen2
2 of 13
Abd-B
1 of 13
al
1 of 13
bap
1 of 13
bcd
1 of 13
btn
1 of 13
Bx
1 of 13
CG5708
1 of 13
Dfd
1 of 13
Dll
1 of 13
Dr
1 of 13
E5
1 of 13
en
1 of 13
eve
1 of 13
exex
1 of 13
eyg
1 of 13
gsb
1 of 13
gsb-n
1 of 13
Gsc
1 of 13
Hmx
1 of 13
ind
1 of 13
inv
1 of 13
jub
1 of 13
lab
1 of 13
lbl
1 of 13
LIMK1
1 of 13
lms
1 of 13
otp
1 of 13
pb
1 of 13
prd
1 of 13
Ptx1
1 of 13
repo
1 of 13
ro
1 of 13
Rx
1 of 13
scro
1 of 13
Scr
1 of 13
slou
1 of 13
tin
1 of 13
toy
1 of 13
unc-4
1 of 13
Unc-115a
1 of 13
Unc-115b
1 of 13
unpg
1 of 13
vnd
1 of 13
Vsx1
1 of 13
Vsx2
1 of 13
Zasp52
1 of 13
zen
1 of 13
zfh1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
zfh2HMC03043
model of  spinocerebellar ataxia 4
CEA
(He et al., 2024)
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
zfh2EAB
exacerbates  intestinal cancer
modeled by ykiS111A.S168A.S250A.UAS.Tag:V5
(Pranoto et al., 2023)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ZFHX3; zinc finger homeobox 3
12 of 14
ZINC FINGER HOMEOBOX 3; ZFHX3
 
ZFHX4; zinc finger homeobox 4
10 of 14
606940
      ZFHX2; zinc finger homeobox 2
      7 of 14
      617828
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      zfh2
      suppressible
      Ras85D
      (Rojas Villa et al., 2019)
      zfh2
      suppressible
      Sox100B
      (Meng et al., 2020)
      zfh2
      suppressible
      Tsc1|gig
      (Rojas Villa et al., 2019)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      InR
      suppressible
      zfh2
      (Rojas Villa et al., 2019)
      Ras85D
      suppressible
      zfh2
      (Rojas Villa et al., 2019)
      Rheb
      suppressible
      zfh2
      (Rojas Villa et al., 2019)
      yki
      enhanceable
      zfh2
      (Pranoto et al., 2023)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      4
      Recombination map
      4-0
      Cytogenetic map
      102C3-102C4
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      102C3-102C4
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      102C1-102C2
      (determined by in situ hybridisation)
      (Fortini et al., 1991)
      Experimentally Determined Recombination Data
      Location

      4-0

      (FlyBase, 2016)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (35)
      Genomic Clones (21)
      cDNA Clones (85)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Tran et al., 2010, Lundell and Hirsh, 1992, Lai et al., 1991)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
            Other Comments

            zfh2 is required for proximal wng development.

            (Whitworth and Russell, 2003)

            eg is necessary for the maintenance of en and zfh2 expression in the serotonin neurons.

            (Lundell and Hirsh, 1998)

            One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus Engrailed binding site.

            (Kalionis and O'Farrell, 1993)

            Assayed in an analysis of chromosome 4 using pulsed field gel electrophoresis.

            (Locke and McDermid, 1993)

            Profile of zfh2 expression in the larval CNS shows intriguing overlap with Ddc expression in specific serotonin and dopamine neurons. The product of zfh2 binds to a protein binding site in the Ddc promoter.

            (Lundell and Hirsh, 1992)

            The product of zfh2 possesses three homeodomains and sixteen C2H2 zinc fingers. The novel arrangement of interspersed homeodomain and zinc-finger motifs in the primary sequences of the zfh1 and zfh2 gene products may signify an unusual mechanism of transcriptional regulation by these products.

            (Fortini et al., 1991)

            The expression pattern of zfh2 suggests that the protein may be involved in neurogenesis.

            (Lai et al., 1991)
            Relationship to Other Genes
            Source for database merge of
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: zfh2 CG1449

            (Zhong, 1999.11)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (11)
            Reported As
            Symbol Synonym
            CG1449
            (Berlandi et al., 2019, Hosono et al., 2015, Ni et al., 2010.12.1, Zhang et al., 2010, Keleman et al., 2009.8.5)
            ZFH-2
            (Lundell and Hirsh, 1994)
            ZFH2
            (Kanai et al., 2005)
            Zfh-2
            (Klemm et al., 2025, Benítez et al., 2009, Mettler et al., 2006, Karcavich and Doe, 2005, Lundell et al., 2003, Isshiki et al., 2001)
            Zfh2
            (Pollington et al., 2023, Baonza et al., 2022, Guan et al., 2022, Kang et al., 2022, Boumard and Bardin, 2021, Everetts et al., 2021, Martín et al., 2017, Huang et al., 2013, Kohwi et al., 2011, Beckervordersandforth et al., 2008, Nusinow et al., 2008, Spresser et al., 2008, Tran and Doe, 2008, Slawson et al., 2006, Vogler and Urban, 2003)
            zfh-2
            (Giraud et al., 2021, Kojima, 2017, Guarner et al., 2014, Dichtel-Danjoy et al., 2009, Guntur and Lundell, 2008, Guntur and Lundell, 2006, Sousa-Neves et al., 2005, Vogler and Urban, 2004, Baena-Lopez et al., 2003, Whitworth and Russell, 2003, Kramps et al., 2002, Podemski et al., 2001, Bowles et al., 2000, Leach et al., 2000, Locke et al., 2000, Whitworth and Russell, 2000, Locke et al., 1999, Locke et al., 1998, Lundell and Hirsh, 1998, Ahmed and Podemski, 1997, Kalionis and O'Farrell, 1993, Lundell and Hirsh, 1993, Hashimoto et al., 1992, Fortini et al., 1991, Lai et al., 1991)
            zfh2
            (Li et al., 2025, Montemurro et al., 2025, Plygawko et al., 2025, Drewell et al., 2024, Fisher et al., 2023, Floc'hlay et al., 2023, Fourth Chromosome Resource Project and Newfeld, 2022-, Bilder et al., 2021, Xie et al., 2021, Meng et al., 2020, Zhe et al., 2020, Herrera and Bach, 2019, Shih et al., 2019, Shokri et al., 2019, Ahmed-de-Prado and Baonza, 2018, Doupé et al., 2018, Gene Disruption Project members, 2018-, Stuelten et al., 2018, Turcot et al., 2018, Verghese and Su, 2018, Transgenic RNAi Project members, 2017-, Zajitschek et al., 2017, Bürglin and Affolter, 2016, Helenius et al., 2016, Doggett et al., 2015, Enriquez et al., 2015, Javeed et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Esslinger et al., 2013, Li et al., 2013, Perea et al., 2013, Salzman et al., 2013, Wells et al., 2013, Riddle et al., 2012, Rodriguez et al., 2012, Spokony and White, 2012.5.22, Touma et al., 2012, Davis et al., 2011, Weake et al., 2011, Tran et al., 2010, Dichtel-Danjoy et al., 2009, Perea et al., 2009, Riddle et al., 2008, Terriente et al., 2008, Akdemir et al., 2007, Beltran et al., 2007, de Navascués and Modolell, 2007, Johansson et al., 2007, Tran and Doe, 2007, Burgler and Macdonald, 2005, Stark et al., 2005, Podemski et al., 2004, Sun et al., 2004, Klebes et al., 2002)
            Name Synonyms
            Zinc finger homeodomain-2
            (Guntur and Lundell, 2008)
            Zn finger homeodomain 2
            (Davis et al., 2011)
            zinc finger homeodomain 2
            (Helenius et al., 2016, Enriquez et al., 2015, Perea et al., 2009, Terriente et al., 2008)
            zn finger homeodomain 2
            (Javeed et al., 2015)
            Secondary FlyBase IDs
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 103 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (179)