awol, absent without leave
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MCPH1 using the Feature Mapper tool.
RT-PCR experiments show that MCPH1 transcripts are present at all developmental stages. Highest embryonic levels of MCPH1 transcripts are seen in syncytial stage embryos, distributed throughout the embryo. The different isoforms were assayed by RT-PCR. Both splice and unspliced forms (intron 7) are found in embryos but only the spliced form is observed in testis.
MCPH1 is cyclically localized during the cell cycle, co-localizing with the DNA during interphase, but not with mitotic chromosomes.
GBrowse - Visual display of RNA-Seq signalsView Dmel\MCPH1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: MCPH1 CG8981
The gene is named "absent without leave" based on the mutant phenotype of acentrosomal mitotic spindles.