FlyBase Gene Report: Dmel\Pde11

General Information

Symbol

Dmel\Pde11

Species

D. melanogaster

Name

Phosphodiesterase 11

Annotation Symbol

CG34341

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085370

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

3',5'-cyclic-nucleotide phosphodiesterase (3.1.4.17)

3',5'-cyclic-GMP phosphodiesterase (3.1.4.35)

3',5'-cyclic-AMP phosphodiesterase (3.1.4.53)

Gene Summary

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Dual-specificity phosphodiesterase that catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. (UniProt, Q9VJ79)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

36F6-36F6

Sequence location

2L:18,532,025..18,590,342 [-]

Recombination map

2-53

RefSeq locus

NT_033779 REGION:18532025..18590342

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables 3',5'-cyclic-AMP phosphodiesterase activity

inferred from direct assay

(Day, 2005)

enables 3',5'-cyclic-GMP phosphodiesterase activity

inferred from direct assay

(Day, 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables 3',5'-cyclic-AMP phosphodiesterase activity

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

enables 3',5'-cyclic-GMP phosphodiesterase activity

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

enables 3',5'-cyclic-nucleotide phosphodiesterase activity

inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971

(InterPro Project Members, 2004-)

enables phosphoric diester hydrolase activity

inferred from electronic annotation with InterPro:IPR023088, InterPro:IPR023174

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in cAMP metabolic process

inferred from direct assay

(Day, 2005)

involved_in cGMP metabolic process

inferred from direct assay

(Day, 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in negative regulation of cAMP/PKA signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

Protein Family (UniProt)

Belongs to the cyclic nucleotide phosphodiesterase family. (Q9VJ79)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

3',5'-cyclic-GMP phosphodiesterase activity

3',5'-cyclic GMP + H2O = GMP + H(+) (3.1.4.35)

RHEA 16957: 3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic AMP + H2O = AMP + H(+) (3.1.4.53)

RHEA 25277: 3',5'-cyclic-nucleotide phosphodiesterase activity

a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+) (3.1.4.17)

RHEA 14653:

Summaries

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES -: Cyclic-nucleotide phosphodiesterases are hydrolases that catalyze the hydrolysis of a nucleoside cyclic phosphate into a nucleoside phosphate.

Protein Function (UniProtKB)

(UniProt, Q9VJ79)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pde11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJ79)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pde11-RB

FBtr0112544

NM_136041

5639

1451

Pde11-RC

FBtr0112545

NM_001103707

5886

1407

Pde11-RD

FBtr0303162

NM_001201908

5506

1161

Pde11-RE

FBtr0303163

NM_001201909

6515

1117

Pde11-RF

FBtr0343830

NM_001299115

6456

1451

Pde11-RG

FBtr0343831

NM_001299116

4973

1407

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pde11-PB

FBpp0111456

160.9

1451

6.46

FBpp0111457

155.6

1407

6.38

FBpp0292261

130.0

1161

6.09

FBpp0292262

124.7

1117

5.90

FBpp0310380

160.9

1451

6.46

FBpp0310381

155.6

1407

6.38

X2J8Z1

NP_001286045

AHN54559

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1451 aa isoforms: Pde11-PB, Pde11-PF

1407 aa isoforms: Pde11-PC, Pde11-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pde11 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.62

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

posterior endoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)

trunk visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

larval muscle system

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

gonad

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{769.FSVS-1}Pde11^CPTI002206

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult antennal lobe | faint

(Knowles-Barley, 2011.8.24)

nodulus

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pde11 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pde11

View exonic expression by tissue for Dmel\Pde11

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085370

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35107/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085370

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085370

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085370

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10231

Flygut - An atlas of the Drosophila adult midgut

FBgn0085370

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Pde11

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pde11

Transgenic constructs containing regulatory region of Pde11

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)Exel6040

(Ryder, 2004.4.26)

Df(2L)M36F-2

(Marygold, 2005.1.19)

Df(2L)M36F-S6

(Marygold, 2005.1.19)

Df(2L)TW50

(Marygold, 2005.1.19)

Gene not disrupted in

Df(2L)H20

(Marygold, 2005.1.19)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pde11^GD8930

lethal, with Scer\GAL4^Mef2.PR

Pde11^GD6910

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Pde11^GD6910

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pde11^GD8930

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Pde11^GD8930

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Pde11^GD8930

viable

Pde11^e02198

Sterility

Allele

fertile

Pde11^e02198

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Pde11^GD8930

some die during pupal stage, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^pnr-MD237

Pde11^GD8930

Phenotype manifest in

Allele

chaeta | increased number, with Scer\GAL4^pnr-MD237

Pde11^GD8930

mesonotum, with Scer\GAL4^pnr-MD237

Pde11^GD8930

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\PDE5A

11 of 14

Yes

Hsap\PDE11A

8 of 14

Hsap\PDE2A

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Hsap\PDE7B

4 of 14

Yes

Hsap\PDE1C

3 of 14

Hsap\PDE3A

3 of 14

Yes

Hsap\PDE3B

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Pde5a

10 of 14

Yes

Rnor\Pde11a

9 of 14

Yes

Rnor\Pde2a

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Rnor\Pde1b

3 of 14

Rnor\Pde3a

3 of 14

Yes

Rnor\Pde3b

3 of 14

Yes

Rnor\Pde4d

3 of 14

Rnor\Pde7b

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Pde5a

10 of 14

Yes

Mmus\Pde11a

8 of 14

Yes

Mmus\Pde2a

4 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Mmus\Pde1b

3 of 14

Mmus\Pde3a

3 of 14

Yes

Mmus\Pde3b

3 of 14

Yes

Mmus\Pde4b

3 of 14

Mmus\Pde7b

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (34)

Xtro\pde5a

9 of 13

Yes

Xtro\pde2a

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101734687

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\pde3b

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (27)

Drer\pde5ab

10 of 14

Yes

Drer\pde11a

8 of 14

Drer\pde11al

8 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

Yes

Drer\pde3b

3 of 14

Yes

Drer\pde4bb

3 of 14

Drer\pde6c

3 of 14

Drer\pde7a

3 of 14

Yes

Drer\pde8b

3 of 14

Drer\pde9aa

3 of 14

Drer\pde9ac

3 of 14

Drer\si:dkey-219c10.4

3 of 14

Drer\pde1a

2 of 14

Drer\pde2a

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\pde-5

5 of 14

Yes

Cele\pde-2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP008646

11 of 12

Yes

Agam\AgaP_AGAP004119

4 of 12

Agam\AgaP_AGAP005536

3 of 12

Yes

Agam\AgaP_AGAP008304

3 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PDE2

4 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pde11. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

8 of 13

7 of 13

7 of 13

6 of 13

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PDE3A; phosphodiesterase 3A

model of hypertension and brachydactyly syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDE5A; phosphodiesterase 5A

11 of 14

603310

PDE11A; phosphodiesterase 11A

8 of 14

604961

PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2

primary pigmented nodular adrenocortical disease 2

PDE2A; phosphodiesterase 2A

4 of 14

602658

INTELLECTUAL DEVELOPMENTAL DISORDER WITH PAROXYSMAL DYSKINESIA OR SEIZURES; IDDPADS

PDE4A; phosphodiesterase 4A

4 of 14

600126

PDE4C; phosphodiesterase 4C

4 of 14

600128

PDE4D; phosphodiesterase 4D

4 of 14

600129

ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE; ACRDYS2

acrodysostosis

PDE6A; phosphodiesterase 6A

4 of 14

180071

RETINITIS PIGMENTOSA 43; RP43

retinitis pigmentosa 43

PDE6B; phosphodiesterase 6B

4 of 14

180072

PDE6C; phosphodiesterase 6C

4 of 14

600827

CONE DYSTROPHY 4; COD4

PDE7A; phosphodiesterase 7A

4 of 14

171885

PDE7B; phosphodiesterase 7B

4 of 14

604645

PDE1C; phosphodiesterase 1C

3 of 14

602987

DEAFNESS, AUTOSOMAL DOMINANT 74; DFNA74

autosomal dominant nonsyndromic deafness 74

PDE3A; phosphodiesterase 3A

3 of 14

123805

HYPERTENSION AND BRACHYDACTYLY SYNDROME; HTNB

hypertension and brachydactyly syndrome

PDE3B; phosphodiesterase 3B

3 of 14

602047

PDE4B; phosphodiesterase 4B

3 of 14

600127

PDE8A; phosphodiesterase 8A

3 of 14

602972

PDE8B; phosphodiesterase 8B

3 of 14

603390

PDE9A; phosphodiesterase 9A

3 of 14

602973

PDE10A; phosphodiesterase 10A

3 of 14

610652

striatal degeneration 2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61102

DroID - A comprehensive database of gene and protein interactions.

FBgn0085370

MIST (protein-protein) - An integrated Molecular Interaction Database

35107

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-53

Cytogenetic map

36F6-36F6

Sequence location

2L:18,532,025..18,590,342 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36F6-36F6

Limits computationally determined from genome sequence between P{lacW}Aac11^k06710 and P{EP}CG10413^EP2164

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-53

(FlyBase, 2016)

2-53.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93121

w^*; PBac{RB3.WH3}Pde11^DM1/CyO

65571

w¹¹¹⁸; PBac{IT.GAL4}Pde11^1367-G4

36256

y¹ w^*; Mi{MIC}Pde11^MI02899

66762

y¹ w^*; Mi{PT-GFSTF.0}Pde11^{MI02899-GFSTF.0}

81158

y¹ w^*; TI{CRIMIC.TG4.1}Pde11^{CR01019-TG4.1}

34611

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01286}attP2

Kyoto

115276

w¹¹¹⁸; PBac{769.FSVS-1}Pde11^CPTI002206

NIG-Fly

HMS01286

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01286}attP2

VDRC

v103927

P{KK102826}VIE-260B

v25197

w¹¹¹⁸; P{GD8930}v25197

Genomic Clones (44)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (20)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD13096

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0085370

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085370

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : S2 cell lines expressing circCG32369, circMCPH1, circeIF5B, circrl, circPde11, circCG17715, circzfh2, circTao, circcrol, circdrn, circMeltrin, circpxb, circfru, circdati, circstw, circSarm, circStim, circCG2991, circPvr, circHil, circmub, circsxc, circbnl, and circCG9743 were created. The author reports new stable cell lines S2-circMCPH1, S2-circCG32369, S2-Flag-Ddx56 , and S2-Flag-gw.
(Su et al., 2024)

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Pde11 CG15159

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG10231 and CG15159 merged as CG34341 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: Pde11 CG10231

(Day and Davies, 2003.6.10)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

CG10231

(Christis and Munro, 2012, Day, 2005, Wang et al., 2004, Giot et al., 2003, Coulier et al., 2000)

CG15159

(Lin et al., 2015, Christis and Munro, 2012, Schnorrer et al., 2007)

CG34341

(Ibaraki et al., 2021, Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

PDE11

(Song et al., 2017, Davies et al., 2014, Finlayson et al., 2010.3.3, Clemens-Grisham et al., 2008, Day, 2005, Day and Davies, 2003.6.10)

Pde11

(GenetiVision Corporation, 2026-, Lee et al., 2023, Dow et al., 2021, Ibaraki et al., 2021, Lindsey et al., 2021, Pang et al., 2021, Campbell et al., 2019, Gene Disruption Project members, 2018-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Morozova et al., 2015, Ashwal-Fluss et al., 2014, Kwon et al., 2013, Nawaz et al., 2012, Rodriguez et al., 2012, Kong et al., 2010, Cox and Spradling, 2009, Schnorrer et al., 2007)

pde11

(Meltzer et al., 2019)

Name Synonyms

CG15159

Phosphodiesterase 11

(Day and Davies, 2003.6.10)

Secondary FlyBase IDs

FBgn0032686
FBgn0032687

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 71 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35107

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJ79

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VJ79

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJ79

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0085370

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35107/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085370

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085370

FlyMine - An integrated database for Drosophila genomics

FBgn0085370

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34341

MARRVEL_MODEL - MARRVEL (model organism gene)

35107

Linkouts

BioGRID - A database of protein and genetic interactions.

61102

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0085370

DroID - A comprehensive database of gene and protein interactions.

FBgn0085370

DRSC - Results frm RNAi screens

FBgn0085370

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085370

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085370

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10231

Flygut - An atlas of the Drosophila adult midgut

FBgn0085370

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

35107

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

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