FB2025_05 , released December 11, 2025
Gene: Dmel\Pde6
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General Information
Symbol
Dmel\Pde6
Species
D. melanogaster
Name
Phosphodiesterase 6
Annotation Symbol
CG8279
Feature Type
protein_coding_gene
FlyBase ID
FBgn0038237
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
3',5'-cyclic-nucleotide phosphodiesterase (3.1.4.17)
3',5'-cyclic-GMP phosphodiesterase (3.1.4.35)
3',5'-cyclic-AMP phosphodiesterase (3.1.4.53)
Gene Summary
Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:15673286). Has cAMP phosphodiesterase activity in vitro but not in vivo (PubMed:15673286). Has a role regulating cGMP transport in Malpighian tubule principal cells (PubMed:16232123). (UniProt, Q9VFI9)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

PDE5/6

Key Links
Genomic Location
Cytogenetic map
88C3-88C6
Sequence location
Recombination map
3-55
RefSeq locus
NT_033777 REGION:14513901..14558304
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables 3',5'-cyclic-GMP phosphodiesterase activity
inferred from direct assay
(Day et al., 2008, Day et al., 2006, Day, 2005)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VLJ0
(Day et al., 2008)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables 3',5'-cyclic-AMP phosphodiesterase activity
inferred from biological aspect of ancestor with PANTHER:PTN001682918
(GO Reference Genome Project, 2011-)
enables 3',5'-cyclic-GMP phosphodiesterase activity
inferred from biological aspect of ancestor with PANTHER:PTN001682918
(GO Reference Genome Project, 2011-)
enables 3',5'-cyclic-nucleotide phosphodiesterase activity
inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971
(InterPro Project Members, 2004-)
enables phosphoric diester hydrolase activity
inferred from electronic annotation with InterPro:IPR023088, InterPro:IPR023174
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in cGMP metabolic process
inferred from direct assay
(Day et al., 2008, Day et al., 2006)
inferred from direct assay
(Day, 2005)
involved_in negative regulation of nucleobase-containing compound transport
inferred from mutant phenotype
(Day et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in negative regulation of cAMP/PKA signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN001682918
(GO Reference Genome Project, 2011-)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Day et al., 2008, Day et al., 2006)
located_in membrane
inferred from direct assay
(Day et al., 2008, Day et al., 2006)
located_in plasma membrane
inferred from direct assay
(Day et al., 2008)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cyclic nucleotide phosphodiesterase family. (Q9VFI9)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic AMP + H2O = AMP + H(+) (3.1.4.53)
RHEA 25277: 3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic GMP + H2O = GMP + H(+) (3.1.4.35)
RHEA 16957: 3',5'-cyclic-nucleotide phosphodiesterase activity
a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+) (3.1.4.17)
RHEA 14653:
Summaries
Gene Group (FlyBase)
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES -
Cyclic-nucleotide phosphodiesterases are hydrolases that catalyze the hydrolysis of a nucleoside cyclic phosphate into a nucleoside phosphate.
Protein Function (UniProtKB)
Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:15673286). Has cAMP phosphodiesterase activity in vitro but not in vivo (PubMed:15673286). Has a role regulating cGMP transport in Malpighian tubule principal cells (PubMed:16232123).
(UniProt, Q9VFI9)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Pde6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VFI9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pde6-RB
FBtr0300330
NM_142112
6355
1118
Pde6-RC
FBtr0330048
NM_001275637
6101
1124
Pde6-RD
FBtr0345168
NM_001300398
5742
1118
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pde6-PB
FBpp0289559
124.3
1118
5.59
Q9VFI9
NP_650369
AAF55066
Pde6-PC
FBpp0303081
125.0
1124
5.74
A0A0B4KFZ3
NP_001262566
AGB95947
Pde6-PD
FBpp0311378
124.3
1118
5.59
Q9VFI9
NP_001287327
AHN57326
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1118 aa isoforms: Pde6-PB, Pde6-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with PrBP.

(UniProt, Q9VFI9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pde6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.73

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult main segment of Malpighian tubule
(Day et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical plasma membrane
inferred from direct assay
(Day et al., 2008, Day et al., 2006)
located_in membrane
inferred from direct assay
(Day et al., 2008, Day et al., 2006)
located_in plasma membrane
inferred from direct assay
(Day et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pde6 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pde6
Transgenic constructs containing regulatory region of Pde6
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene not disrupted in
Df(3R)HtrA2Df1
(Yacobi-Sharon et al., 2013)
Gene disrupted in
Df(3R)HtrA2Df2
(Yacobi-Sharon et al., 2013)
Inferred from location ( 2 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal immune response | larval stage, with Scer\GAL4c564
increased mortality | larval stage | conditional, with Scer\GAL4c564
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\PDE11A
9 of 14
Yes
Yes
1  
Hsap\PDE5A
8 of 14
No
No
Hsap\PDE6A
5 of 14
No
Yes
Hsap\PDE6B
5 of 14
No
Yes
1  
Hsap\PDE6C
5 of 14
No
Yes
Hsap\PDE10A
5 of 14
No
Yes
Hsap\PDE2A
3 of 14
No
No
0  
Hsap\PDE4A
3 of 14
No
No
Hsap\PDE4B
3 of 14
No
No
Hsap\PDE4C
3 of 14
No
No
Hsap\PDE4D
3 of 14
No
No
1  
Hsap\PDE7A
3 of 14
No
No
Hsap\PDE7B
3 of 14
No
No
Hsap\PDE9A
3 of 14
No
No
Hsap\PDE1A
2 of 14
No
No
Hsap\PDE1B
2 of 14
No
No
Hsap\PDE1C
2 of 14
No
No
Hsap\PDE3A
2 of 14
No
No
Hsap\PDE3B
2 of 14
No
No
Hsap\PDE8A
2 of 14
No
No
Hsap\PDE8B
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (21)
Rnor\Pde5a
8 of 14
Yes
No
Rnor\Pde11a
8 of 14
Yes
No
Rnor\Pde6a
5 of 14
No
Yes
Rnor\Pde6b
5 of 14
No
Yes
Rnor\Pde6c
5 of 14
No
Yes
Rnor\Pde10a
4 of 14
No
Yes
Rnor\Pde2a
3 of 14
No
No
Rnor\Pde4a
3 of 14
No
No
Rnor\Pde4c
3 of 14
No
No
Rnor\Pde7a
3 of 14
No
No
Rnor\Pde9a
3 of 14
No
No
Rnor\Pde1b
2 of 14
No
No
Rnor\Pde3a
2 of 14
No
No
Rnor\Pde3b
2 of 14
No
No
Rnor\Pde4d
2 of 14
No
No
Rnor\Pde7b
2 of 14
No
No
Rnor\Pde8b
2 of 14
No
No
Rnor\Pde1a
1 of 14
No
No
Rnor\Pde1c
1 of 14
No
No
Rnor\Pde4b
1 of 14
No
No
Rnor\Pde8a
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Pde5a
8 of 14
Yes
No
Mmus\Pde11a
7 of 14
No
No
Mmus\Pde6a
5 of 14
No
Yes
Mmus\Pde6b
5 of 14
No
Yes
Mmus\Pde6c
5 of 14
No
Yes
Mmus\Pde10a
5 of 14
No
Yes
Mmus\Pde2a
3 of 14
No
No
Mmus\Pde4a
3 of 14
No
No
Mmus\Pde4c
3 of 14
No
No
Mmus\Pde4d
3 of 14
No
No
Mmus\Pde7a
3 of 14
No
No
Mmus\Pde7b
3 of 14
No
Yes
Mmus\Pde9a
3 of 14
No
No
Mmus\Pde1b
2 of 14
No
No
Mmus\Pde3a
2 of 14
No
No
Mmus\Pde3b
2 of 14
No
No
Mmus\Pde4b
2 of 14
No
No
Mmus\Pde8a
2 of 14
No
No
Mmus\Pde8b
2 of 14
No
No
Mmus\Pde1a
1 of 14
No
No
Mmus\Pde1c
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (24)
Xtro\pde5a
7 of 13
Yes
No
Xtro\pde6a
4 of 13
No
Yes
Xtro\pde6b
4 of 13
No
Yes
Xtro\pde4b
2 of 13
No
No
Xtro\pde4c
2 of 13
No
No
Xtro\pde6c
2 of 13
No
Yes
Xtro\pde7b
2 of 13
No
Yes
Xtro\pde9a
2 of 13
No
No
Xtro\pde10a
2 of 13
No
No
Xtro\pde11a
2 of 13
No
Yes
Xtro\XB990243
2 of 13
No
No
Xtro\cyb5a
1 of 13
No
No
Xtro\pde1a
1 of 13
No
No
Xtro\pde1b
1 of 13
No
No
Xtro\pde1c
1 of 13
No
No
Xtro\pde2a
1 of 13
No
No
Xtro\pde3a
1 of 13
No
Yes
Xtro\pde3b
1 of 13
No
Yes
Xtro\pde4a
1 of 13
No
No
Xtro\pde4d
1 of 13
No
No
Xtro\pde7a
1 of 13
No
Yes
Xtro\pde8a
1 of 13
No
No
Xtro\pde8b
1 of 13
No
No
Xtro\ube2n
1 of 13
No
No
Danio rerio (Zebrafish) (27)
Drer\pde11a
9 of 14
Yes
Yes
Drer\pde11al
8 of 14
No
Yes
Drer\pde5ab
7 of 14
No
No
Drer\pde6a
5 of 14
No
Yes
Drer\pde6b
5 of 14
No
Yes
Drer\pde6c
4 of 14
No
Yes
Drer\pde10a
4 of 14
No
Yes
Drer\pde4a
3 of 14
No
No
Drer\pde4bb
3 of 14
No
No
Drer\pde4ca
3 of 14
No
No
Drer\pde4cb
3 of 14
No
No
Drer\pde4d
3 of 14
No
No
Drer\pde9aa
3 of 14
No
No
Drer\pde9ac
3 of 14
No
No
Drer\si:dkey-219c10.4
3 of 14
No
No
Drer\pde1a
2 of 14
No
No
Drer\pde1cb
2 of 14
No
No
Drer\pde2a
2 of 14
No
Yes
Drer\pde3a
2 of 14
No
No
Drer\pde3b
2 of 14
No
No
Drer\pde4ba
2 of 14
No
No
Drer\pde5aa
2 of 14
No
No
Drer\pde7a
2 of 14
No
No
Drer\pde9ab
2 of 14
No
No
Drer\pde1ca
1 of 14
No
Yes
Drer\pde8a
1 of 14
No
No
Drer\pde8b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\pde-5
7 of 14
Yes
Yes
Cele\pde-1
2 of 14
No
No
Cele\pde-2
2 of 14
No
No
Cele\pde-3
2 of 14
No
No
Cele\pde-4
2 of 14
No
No
Cele\pde-6
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP004119
12 of 12
Yes
Yes
Agam\AgaP_AGAP008646
5 of 12
No
No
Agam\AgaP_AGAP012811
4 of 12
No
Yes
Agam\AgaP_AGAP005536
3 of 12
No
Yes
Agam\AgaP_AGAP008304
3 of 12
No
Yes
Agam\AgaP_AGAP000236
2 of 12
No
No
Agam\AgaP_AGAP002927
2 of 12
No
No
Agam\AgaP_AGAP007163
2 of 12
No
No
Agam\AgaP_AGAP008967
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\PDE2
4 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pde6. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Pde11
8 of 13
Pde4
6 of 13
Pde9
6 of 13
Pde1c
5 of 13
Pde8
5 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 5 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PDE11A; phosphodiesterase 11A
    9 of 14
    604961
     
    PDE5A; phosphodiesterase 5A
    8 of 14
    603310
        PDE6A; phosphodiesterase 6A
        5 of 14
        180071
        PDE6B; phosphodiesterase 6B
        5 of 14
        180072
         
        PDE6C; phosphodiesterase 6C
        5 of 14
        600827
          PDE10A; phosphodiesterase 10A
          5 of 14
          610652
          PDE2A; phosphodiesterase 2A
          3 of 14
          602658
             
            PDE4A; phosphodiesterase 4A
            3 of 14
            600126
                PDE4B; phosphodiesterase 4B
                3 of 14
                600127
                    PDE4C; phosphodiesterase 4C
                    3 of 14
                    600128
                        PDE4D; phosphodiesterase 4D
                        3 of 14
                        600129
                         
                        PDE7A; phosphodiesterase 7A
                        3 of 14
                        171885
                            PDE7B; phosphodiesterase 7B
                            3 of 14
                            604645
                                PDE9A; phosphodiesterase 9A
                                3 of 14
                                602973
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    Interaction Browsers
                                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                                    Please see the Physical Interaction reports below for full details
                                    protein-protein
                                    Physical Interaction
                                    Assay
                                    References
                                    Pde6 - PrBP
                                    anti tag coimmunoprecipitation, anti tag western blot
                                    (Day et al., 2008)
                                    Summary of Genetic Interactions
                                    Interaction Browsers
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Subunit Structure (UniProtKB)
                                    Interacts with PrBP.
                                    (UniProt, Q9VFI9 )
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyBase
                                    External Links
                                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    External Data
                                    Linkouts
                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                    Class of Gene
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    3R
                                    Recombination map
                                    3-55
                                    Cytogenetic map
                                    88C3-88C6
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    88C3-88C6
                                    Limits computationally determined from genome sequence between P{PZ}cv-c06951 and P{PZ}put10460;
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    Experimentally Determined Recombination Data
                                    Location

                                    3-55

                                    (FlyBase, 2016)

                                    3-54.1

                                    (Comeron et al., 2012)
                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (11)
                                    Genomic Clones (37)
                                    cDNA Clones (23)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                      Drosophila Genomics Resource Center cDNA clones

                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                      cDNA Clones, End Sequenced (ESTs)
                                      BDGP DGC clones
                                        Other clones
                                        RNAi and Array Information
                                        Linkouts
                                        DRSC - Results frm RNAi screens
                                        Antibody Information
                                        Laboratory Generated Antibodies
                                         
                                        Commercially Available Antibodies
                                         
                                        Cell Line Information
                                        Publicly Available Cell Lines
                                         
                                          Other Stable Cell Lines
                                           
                                            Other Comments

                                            In addition to its role as a cGMP-specific phosphodiesterase, Pde6 has a role in modulating cGMP transport and efflux in Malpighian tubule cells.

                                            (Day et al., 2006)
                                            Relationship to Other Genes
                                            Source for database merge of
                                            Additional comments
                                            Nomenclature History
                                            Source for database identify of

                                            Source for identity of: Pde6 CG8279

                                            (Day and Davies, 2003.6.10)
                                            Nomenclature comments
                                            Etymology
                                            Synonyms and Secondary IDs (7)
                                            Datasets (0)
                                            Study focus (0)
                                            Experimental Role
                                            Project
                                            Project Type
                                            Title
                                            Study result (0)
                                            Result
                                            Result Type
                                            Title
                                            External Crossreferences and Linkouts ( 50 )
                                            Sequence Crossreferences
                                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                            Other crossreferences
                                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                            FlyMine - An integrated database for Drosophila genomics
                                            InterPro - A database of protein families, domains and functional sites
                                            KEGG Genes - Molecular building blocks of life in the genomic space.
                                            MARRVEL_MODEL - MARRVEL (model organism gene)
                                            Linkouts
                                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                            DroID - A comprehensive database of gene and protein interactions.
                                            DRSC - Results frm RNAi screens
                                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                            Flygut - An atlas of the Drosophila adult midgut
                                            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            References (48)