FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 3',5'-cyclic-nucleotide phosphodiesterase activity ID (Ontology) GO:0004114 (Gene Ontology)
Definition Catalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate.[ PubMed:35216259 ]
Also Known As "3',5' cyclic-nucleotide phosphodiesterase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       6
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 Genes
 3',5'-cyclic-nucleotide phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)       6
     enables | 3',5'-cyclic-nucleotide phosphodiesterase activity       6
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  phosphoric diester hydrolase activity
   |__cyclic-nucleotide phosphodiesterase activity
       |__3',5'-cyclic-nucleotide phosphodiesterase activity  6 rec.
           |__3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
           |__3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
           |__3',5'-cyclic-AMP phosphodiesterase activity 6 rec.
           |   |__calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity
           |   |__calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1 rec.
           |__3',5'-cyclic-GMP phosphodiesterase activity 6 rec.
               |__calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1 rec.
               |__calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1 rec.
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Is a cyclic-nucleotide phosphodiesterase activity
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Synonyms
  • "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT
    "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" RELATED[ EC:3 ]
    "3',5'-cyclonucleotide phosphodiesterase activity" RELATED[ EC:3 ]
    "3',5'-nucleotide phosphodiesterase activity" RELATED[ EC:3 ]
    "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" RELATED[ EC:3 ]
    "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" RELATED[ EC:3 ]
    "cyclic 3',5'-mononucleotide phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic 3',5'-nucleotide phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic 3',5'-phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic AMP phosphodiesterase activity" NARROW[ EC:3 ]
    "cyclic nucleotide phosphodiesterase activity" RELATED[ EC:3 ]
    "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" RELATED[ EC:3 ]
    "nucleoside 3',5'-cyclic phosphate diesterase activity" RELATED[ EC:3 ]
    "nucleoside-3',5-monophosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "PDE" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.4.17
MetaCyc:3.1.4.17-RXN
Reactome:R-HSA-162425 "p-S295-PDE3B hydrolyses cAMP to AMP"
RHEA:14653
RHEA:70575
RHEA:72675