FB2026_03 , released September 17, 2026
CV Term Report
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Term phosphoric diester hydrolase activity ID (Ontology) GO:0008081 (Gene Ontology)
Definition Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.[ EC:3 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphoric diester hydrolase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphoric diester hydrolase activity       --
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  hydrolase activity, acting on ester bonds
   |__phosphoric ester hydrolase activity
       |__phosphoric diester hydrolase activity  39 rec.
           |__7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
           |__[acyl-carrier-protein] phosphodiesterase activity
           |__alkylglycerophosphoethanolamine phosphodiesterase activity
           |__C-type glycerophospholipase activity 6 rec.
           |   |__GPI anchor phospholipase C activity
           |   |__lysophospholipase C activity
           |   |__phosphatidylcholine phospholipase C activity 1 rec.
           |   |__phosphatidylglycerol phospholipase C activity
           |   |__phosphatidylinositol phospholipase C activity 1 rec.
           |   |__phosphatidylinositol-4,5-bisphosphate phospholipase C activity 3 rec.
           |__CMP-N-acylneuraminate phosphodiesterase activity
           |__cyclic-guanylate-specific phosphodiesterase activity
           |__cyclic-nucleotide phosphodiesterase activity 9 rec.
           |   |__2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
           |   |__2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
           |   |__3',5'-cyclic-nucleotide phosphodiesterase activity(+) 6 rec.
           |__D-type glycerophospholipase activity 2 rec.
           |   |__cardiolipin phospholipase D activity 1 rec.
           |   |__glycosylphosphatidylinositol phospholipase D activity
           |   |__GPI anchor phospholipase D activity
           |   |__N-acylphosphatidylethanolamine-specific phospholipase D activity
           |__dolichylphosphate-glucose phosphodiesterase activity
           |__dolichylphosphate-mannose phosphodiesterase activity
           |__glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity
           |__glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity
           |__glycerophosphocholine cholinephosphodiesterase activity
           |__glycerophosphocholine phosphodiesterase activity 6 rec.
           |__glycerophosphodiester phosphodiesterase activity 1 rec.
           |__glycerophosphoinositol glycerophosphodiesterase activity
           |__glycerophosphoinositol inositolphosphodiesterase activity
           |__GPI-mannose ethanolamine phosphate phosphodiesterase activity 1 rec.
           |__phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
           |__phosphodiesterase I activity
           |__phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity
           |__phosphoribosyl 1,2-cyclic phosphate phosphodiesterase activity
           |__protein adenylylhydrolase activity 1 rec.
           |__RNA 2',3'-cyclic 3'-phosphodiesterase activity
           |__serine-ethanolaminephosphate phosphodiesterase activity
           |__sphingomyelin phosphodiesterase activity 6 rec.
           |   |__acid sphingomyelin phosphodiesterase activity 3 rec.
           |   |__neutral sphingomyelin phosphodiesterase activity 1 rec.
           |   |__sphingomyelin phosphodiesterase D activity 1 rec.
           |__tyrosyl-DNA phosphodiesterase activity 1 rec.
           |   |__3'-tyrosyl-DNA phosphodiesterase activity 1 rec.
           |   |__5'-tyrosyl-DNA phosphodiesterase activity 1 rec.
           |__tyrosyl-RNA phosphodiesterase activity
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Is a phosphoric ester hydrolase activity
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  • "phosphodiesterase" NARROW
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EC:3.1.4.-
Reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends"