FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term 3',5'-cyclic-GMP phosphodiesterase activity ID (Ontology) GO:0047555 (Gene Ontology)
Definition Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.
Also Known As "3',5' cyclic-GMP phosphodiesterase activity" ; "cGMP phosphodiesterase activity" ; "cGMP-specific phosphodiesterase activity" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       6
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 3',5'-cyclic-GMP phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)       6
     enables | 3',5'-cyclic-GMP phosphodiesterase activity       6
Spanning Tree (Parents/Children)
Only view relationship: 
  cyclic-nucleotide phosphodiesterase activity
   |__3',5'-cyclic-nucleotide phosphodiesterase activity
       |__3',5'-cyclic-GMP phosphodiesterase activity  6 rec.
           |__calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1 rec.
           |__calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a 3',5'-cyclic-nucleotide phosphodiesterase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "3',5' cyclic-GMP phosphodiesterase activity" EXACT
    "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" RELATED[ EC:3 ]
    "cGMP phosphodiesterase activity" EXACT
    "cGMP-PDE" RELATED[ EC:3 ]
    "cGMP-specific phosphodiesterase activity" EXACT
    "cyclic 3',5'-GMP phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic GMP phosphodiesterase activity" EXACT
    "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.1.4.35
MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN
Reactome:R-HSA-4086392 "PDE6 hydrolyses cGMP to GMP"
Reactome:R-HSA-418456 "cGMP is degraded by PDEs"
Reactome:R-HSA-74059 "PDE6 hydrolyses cGMP to GMP"
RHEA:16957