FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 3',5'-cyclic-GMP phosphodiesterase activity ID (Ontology) GO:0047555 (Gene Ontology)
Definition Catalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+.
Also Known As "3',5' cyclic-GMP phosphodiesterase activity" ; "cGMP phosphodiesterase activity" ; "cGMP-specific phosphodiesterase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 3',5'-cyclic-GMP phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 3',5'-cyclic-GMP phosphodiesterase activity
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  cyclic-nucleotide phosphodiesterase activity
   |__3',5'-cyclic-nucleotide phosphodiesterase activity
       |__3',5'-cyclic-GMP phosphodiesterase activity  6 rec.
           |__calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1 rec.
           |__calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1 rec.
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Is a 3',5'-cyclic-nucleotide phosphodiesterase activity
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Synonyms
  • "3',5' cyclic-GMP phosphodiesterase activity" EXACT
    "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" RELATED[ EC:3 ]
    "cGMP phosphodiesterase activity" EXACT
    "cGMP-PDE" RELATED[ EC:3 ]
    "cGMP-specific phosphodiesterase activity" EXACT
    "cyclic 3',5'-GMP phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic GMP phosphodiesterase activity" EXACT
    "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" RELATED[ EC:3 ]
    "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT
Secondary IDs
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EC:3.1.4.35
MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN
Reactome:R-HSA-4086392 "PDE6 hydrolyses cGMP to GMP"
Reactome:R-HSA-418456 "cGMP is degraded by PDEs"
Reactome:R-HSA-74059 "PDE6 hydrolyses cGMP to GMP"
RHEA:16957