FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 3',5'-cyclic-AMP phosphodiesterase activity ID (Ontology) GO:0004115 (Gene Ontology)
Definition Catalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+.
Also Known As "3',5' cAMP-specific phosphodiesterase activity" ; "3',5'-cAMP-specific phosphodiesterase activity" ; "3',5'-cyclic-AMP-specific phosphodiesterase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 3',5'-cyclic-AMP phosphodiesterase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 3',5'-cyclic-AMP phosphodiesterase activity
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  cyclic-nucleotide phosphodiesterase activity
   |__3',5'-cyclic-nucleotide phosphodiesterase activity
       |__3',5'-cyclic-AMP phosphodiesterase activity  6 rec.
           |__calmodulin-activated 3',5'-cyclic-AMP phosphodiesterase activity
           |__calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1 rec.
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Is a 3',5'-cyclic-nucleotide phosphodiesterase activity
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Synonyms
  • "3',5' cAMP-specific phosphodiesterase activity" EXACT
    "3',5'-cAMP-specific phosphodiesterase activity" EXACT
    "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT
    "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT
    "cAMP-specific phosphodiesterase activity" EXACT
    "cyclic AMP-specific phosphodiesterase activity" EXACT
Secondary IDs
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EC:3.1.4.53
MetaCyc:RXN0-5038
Reactome:R-HSA-111962 "PDE4A,C,D hydrolyse cAMP"
Reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases"
Reactome:R-HSA-9629675 "PDE3A hydrolyses cAMP to AMP"
Reactome:R-HSA-9644869 "p-S54-PDE4B hydrolyses cAMP"
Reactome:R-HSA-9705507 "PDE3B hydrolyses cAMP to AMP"
Reactome:R-HSA-9708261 "PDE4A hydrolyses cAMP to AMP"
Reactome:R-HSA-9865748 "PDE4D5 in p-S26-ANXA2:PP2A:PDE4D5:ITGA5:ITGB1:fibronectin hydrolyzes cAMP to yield AMP"
RHEA:25277