Dear Flybase
Personal communication to Flybase: Cyclic nucleotide Phosphodiesterases
Day, Jonathan Peter and Davies, Shireen-A.
We would like to propose a nomenclature for the genes encoding cyclic
nucleotide-specific phosphodiesterases (PDEs) in <italic>Drosophila
melanogaster. </italic>
Most of these remain as CG numbers although they have been recently
annotated as PDEs. However, each has a clear similarity to one member
of vertebrate gene family, so I propose that they are named
accordingly.
I have attached the gene list for your consideration.
Thank you.
Shireen Davies
CG no. Closest vertebrate homologue % similarity Proposed Deduced function
(Accession number) % identity nomenclature
(Catalytic domain)
8279 C. familiaris PDE6 (CAB98144) 173/249: 69% PDE6 cGMP-specific PDE
127/249: 51%
10231 H. sapiens PDE11a (BAB 16371) 231/241: 96% PDE11 cAMP-, cGMP-specific
PDE
185/241: 77%
14940 H. sapiens PDE1C (Q14123) 152/243: 63% PDE1c Ca2+/calmodulin-sensitive
cGMP-specific PDE
193/243: 79%
32648 H. sapiens PDE9A (NP002597) 181/238: 76% PDE9 cGMP-specific PDE
149/238: 63%
5411 H. sapiens PDE8A1 (060658) 224/285: 79% PDE8 cAMP-specific PDE
171/285: 60%