FB2026_02 , released June 18, 2026
Allele: Dmel\MCPH1d2
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General Information
Symbol
Dmel\MCPH1d2
Species
D. melanogaster
Name
FlyBase ID
FBal0242000
Feature type
allele
Associated gene
Dmel\MCPH1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Brunk et al., 2007)
Progenitor genotype
P{GawB}MCPH1NP6229
(Brunk et al., 2007)
Cytology
Description

A 1.6 kb deletion involving exons 1-4 of MCPH1.

(Brunk et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  microcephaly
      CEA
      (Brunk et al., 2007)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MCPH1d1/MCPH1d2 animals are viable with an early maternal effect lethal phenotype.

      The homozygous MCPH1d2 maternal effect lethal phenotype involves cell cycle arrest in a metaphase-like stage.

      At early developmental stages, homozygous MCPH1d2 embryos lacking maternal MCPH1 display at most a narrow zone of clearing of cytoplasm around the egg periphery without pole cell formation or cellularisation.

      Homozygous MCPH1d2 embryos lacking maternal MCPH1 show centrosomal abnormalities from the first mitotic cycle.

      (Brunk et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MCPH1d2
      mcph1d2
      (Brunk et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)