FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zfh2HMC03043
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General Information
Symbol
Dmel\zfh2HMC03043
Species
D. melanogaster
Name
FlyBase ID
FBal0292255
Feature type
allele
Associated gene
Dmel\zfh2
Associated Insertion(s)
Carried in Construct
P{TRiP.HMC03043}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMC03043}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMC03043
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  spinocerebellar ataxia 4
      CEA
      (He et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of zfh2HMC03043 under the control of Scer\GAL4esg.PU (in combination with tub-Gal80[ts] to restrict expression to the adult stage) leads to a decrease in the cell size of both enteroblasts and intestinal stem cells, and a decrease in the nuclear size of enteroblasts in adult guts when compared to controls.

      Expression of zfh2HMC03043 under the control of Scer\GAL4Su(H).GBE (in combination with tub-Gal80[ts]) leads to a decrease in the cell size, nuclear size and cell volume of enteroblasts in adult guts when compared to controls. It impairs Dextran Sulfate Sodium (DSS)-induced intestinal stem cell proliferation, prevents DSS-induced enteroblast activation (decreased cell circulatory and increased number of cells with membrane protrusions) and blocks DSS-induced enteroblast differentiation compared to control adults.

      (Rojas Villa et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      zfh2HMC03043
      Name Synonyms
      Secondary FlyBase IDs
        References (6)